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    Patch and method for producing the same
    4.
    发明授权
    Patch and method for producing the same 有权
    补片及其制作方法

    公开(公告)号：US09511051B2

    公开(公告)日：2016-12-06

    申请号：US14417205

    申请日：2013-07-25

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

    IPC分类号： A61K31/407 ,  A61K47/06 ,  A61K9/70 ,  A61K47/14 ,  A61K47/12

    CPC分类号： A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

    摘要： A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

    摘要翻译： 在包含支撑层和粘合剂层的贴剂中，粘合剂层包含游离的阿替那非，马来酸碱金属盐和橡胶基粘合剂。

    PATCH PREPARATION CONTAINING AMINE OXIDE
    6.
    发明申请
    PATCH PREPARATION CONTAINING AMINE OXIDE 审中-公开
    含有氧化铝的配方配方

    公开(公告)号：US20140093555A1

    公开(公告)日：2014-04-03

    申请号：US14039993

    申请日：2013-09-27

    申请人： Nitto Denko Corporation

    发明人： Masato NISHIMURA ,  Yoshitaka INOUE ,  Yoshiaki ITO

    IPC分类号： A61K9/70 ,  A61K31/4418 ,  A61K31/404

    CPC分类号： A61K9/7061 ,  A61K9/7046 ,  A61K31/404 ,  A61K31/4418

    摘要： The present invention provides a patch preparation containing a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a drug, amine oxide, a low-polar liquid component based on an organic compound having an angle of 0-19° as calculated by the formula (I): angle(°)=arctan(inorganic value/organic value)×(180/π) and using an inorganic value and an organic value on an organic conceptual diagram, and an adhesive base, and the adhesive layer has an amine oxide content of 0.1-5 wt % and a low-polar liquid component content of 30-50 wt %.

    摘要翻译： 本发明提供了一种在载体的至少一个表面上含有支持体和粘合剂层的贴片制剂，其中粘合剂层含有药物，氧化胺，基于角度为0的有机化合物的低极性液体组分 -19°，角度（°）= arctan（无机值/有机值）×（180 /＆pgr），在有机概念图上使用无机值和有机值，粘合剂 碱，并且粘合剂层的氧化胺含量为0.1-5重量％，低极性液体组分含量为30-50重量％。