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公开(公告)号：US10441551B2
公开(公告)日：2019-10-15
申请号：US15769393
申请日：2016-10-24
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Atsushi Sonobe , Akio Takeuchi , Yasunori Takada
IPC: A61K9/70 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/32 , A61K47/44 , A61K31/4468
Abstract: A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule.
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公开(公告)号：US20190105391A1
公开(公告)日：2019-04-11
申请号：US16209084
申请日：2018-12-04
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Masayuki Suzuki , Hiroaki Okutsu , Takashi Yasukochi , Yasunori Takada
Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.
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Patent Agency Ranking
公开(公告)号：US09511051B2
公开(公告)日：2016-12-06
申请号：US14417205
申请日：2013-07-25
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Masayuki Suzuki , Hiroaki Okutsu , Takashi Yasukochi , Yasunori Takada
IPC: A61K31/407 , A61K47/06 , A61K9/70 , A61K47/14 , A61K47/12
CPC classification number: A61K47/12 , A61K9/7038 , A61K9/7046 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/407 , A61K31/55 , A61K47/06 , A61K47/10 , A61K47/14 , A61M37/00
Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.
Abstract translation: 在包含支撑层和粘合剂层的贴剂中，粘合剂层包含游离的阿替那非，马来酸碱金属盐和橡胶基粘合剂。
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公开(公告)号：US20150202183A1
公开(公告)日：2015-07-23
申请号：US14416964
申请日：2013-07-25
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Masayuki Suzuki , Hiroaki Okutsu , Takashi Yasukochi , Yasunori Takada
IPC: A61K31/407 , A61K47/14 , A61K9/70
CPC classification number: A61K47/12 , A61K9/7038 , A61K9/7046 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/407 , A61K31/55 , A61K47/06 , A61K47/10 , A61K47/14 , A61M37/00
Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.
Abstract translation: 在包含支撑层和粘合剂层的贴片中，粘合剂层包括阿替那平和/或其药学上可接受的盐，棕榈酸异丙酯和粘合剂基剂。
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公开(公告)号：US10022445B2
公开(公告)日：2018-07-17
申请号：US14416983
申请日：2013-07-25
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Atsushi Sonobe , Takashi Yasukochi , Yasunori Takada
Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
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公开(公告)号：US09687474B2
公开(公告)日：2017-06-27
申请号：US14416964
申请日：2013-07-25
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Masayuki Suzuki , Hiroaki Okutsu , Takashi Yasukochi , Yasunori Takada
CPC classification number: A61K47/12 , A61K9/7038 , A61K9/7046 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/407 , A61K31/55 , A61K47/06 , A61K47/10 , A61K47/14 , A61M37/00
Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.
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公开(公告)号：US09163164B2
公开(公告)日：2015-10-20
申请号：US14339487
申请日：2014-07-24
Inventor： Tomohiro Shinoda , Hisaaki Isaji , Yasunori Takada , Tsuguki Nishihara , Atsushi Matsushima , Chiaki Yoshida , Tsuyoshi Takamiya
CPC classification number: C09J7/0282 , B32B7/12 , B32B27/08 , B32B27/22 , B32B27/306 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/728 , B32B2555/02 , C08J7/04 , C08J7/045 , C08J2375/04 , C08L75/04 , C09J7/25 , C09J7/29 , C09J2429/001 , C09J2475/006 , Y10T428/24851 , Y10T428/2848 , Y10T428/31551
Abstract: A support film for tape which is used for a tape includes a film-shaped support formed of polyurethane, a barrier layer which includes polyvinyl alcohol and a layered inorganic compound and is formed on a surface of the support, and an undercoat layer which is disposed between the support and the barrier layer, and which causes the support and the barrier layer to adhere to each other.
Abstract translation: 用于胶带的胶带用支撑膜包括由聚氨酯形成的膜状支撑体，包含聚乙烯醇和层状无机化合物的阻挡层，并且形成在载体的表面上，并且设置有底涂层 在支撑体和阻挡层之间，并且使得支撑体和阻挡层彼此粘附。
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