公开(公告)号：US6124326A

公开(公告)日：2000-09-26

申请号：US873124

申请日：1997-06-11

申请人： Gabriele Pergande ,  Werner E. Muller ,  Neville Osborne ,  Heinz Ulrich

发明人： Gabriele Pergande ,  Werner E. Muller ,  Neville Osborne ,  Heinz Ulrich

IPC分类号： A61K31/44

CPC分类号： A61K31/44

摘要： The invention relates to the use of flupirtine or its salts for the production of a medicament for the prophylaxis and therapy of disorders which accompany an unphysiologically high cell death rate. Of particular importance here is the treatment of organ disorders with cell-destroying processes, such as myocardial infarct, shock kidney, shock lung, senile macular degeneration or traumas as a result of mechanical, thermal, radiation or toxic influences.

摘要翻译： 本发明涉及氟吡汀或其盐在生产用于预防和治疗伴随非生理学上高细胞死亡率的病症的药物中的用途。 在这里特别重要的是由于机械，热，辐射或毒性影响，细胞破坏过程如心肌梗塞，休克肾，休克肺，老年性黄斑变性或创伤治疗器官功能障碍。

公开(公告)号：US6117899A

公开(公告)日：2000-09-12

申请号：US285460

申请日：1999-04-02

申请人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

发明人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

IPC分类号： C07D339/04 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  A61K31/385 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10

CPC分类号： A61K31/385 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  Y10S514/866

摘要： The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone.The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

摘要翻译： 本发明涉及使用R - （ - ） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺来合成用于治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素，和/或其它添加剂或稳定剂或佐剂如维生素E，维生素C，NADH，NADPH和泛醌一起使用。 本发明还涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物及其盐，酯和酰胺在制备用于治疗疾病的药物中的应用 葡萄糖转运蛋白的功能有限或含量降低。

公开(公告)号：US5693664A

公开(公告)日：1997-12-02

申请号：US360924

申请日：1994-12-21

申请人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

发明人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

IPC分类号： C07D339/04 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  A61K31/385 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10

CPC分类号： A61K31/385 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  Y10S514/866

摘要： The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

摘要翻译： 本发明涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺用于合成药物治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素，和/或其它添加剂或稳定剂或佐剂如维生素E，维生素C，NADH，NADPH和泛醌一起使用。 本发明还涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物及其盐，酯和酰胺在制备用于治疗疾病的药物中的应用 葡萄糖转运蛋白的功能有限或含量降低。

公开(公告)号：US5084481A

公开(公告)日：1992-01-28

申请号：US476042

申请日：1990-02-08

申请人： Heinz Ulrich ,  Carl-Heinrich Weischer ,  Jurgen Engel ,  Helmut Hettche

发明人： Heinz Ulrich ,  Carl-Heinrich Weischer ,  Jurgen Engel ,  Helmut Hettche

IPC分类号： A61K31/047 ,  A61K31/19 ,  A61K31/20 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00

CPC分类号： A61K31/19 ,  A61K31/20 ,  Y10S514/886

摘要： Pharmaceutical compositions and their preparation which contain dihydrolipoic acid or its pharmaceutically acceptable salts as active substance. The pharmaceutical compositions have a cytoprotective effect and are suitable for combatting pain and inflammatory disorders.

摘要翻译： 含有二氢硫辛酸或其药学上可接受的盐作为活性物质的药物组合物及其制备。 药物组合物具有细胞保护作用，适用于对抗疼痛和炎症性疾病。