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1.发明授权Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae 失效R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 作为其后遗症
公开(公告)号：US5948810A
公开(公告)日：1999-09-07
申请号：US878843
申请日：1997-06-19
申请人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
发明人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
IPC分类号： C07D339/04 , A61K31/19 , A61K31/22 , A61K31/355 , A61K31/385 , A61K38/28 , A61P3/08 , A61P3/10
CPC分类号： A61K31/385 , A61K31/19 , A61K31/22 , A61K31/355 , Y10S514/866
摘要： The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance.
摘要翻译： 本发明涉及使用R - （ - ） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺来合成用于治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。
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2.发明授权Use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae 失效R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 作为其后遗症公开(公告)号：US06284787B1
公开(公告)日：2001-09-04
申请号：US09628295
申请日：2000-07-28
申请人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
发明人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
IPC分类号： A61K31385
CPC分类号： A61K31/385 , A61K31/19 , A61K31/22 , A61K31/355 , Y10S514/866
摘要： The invention relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin B, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.
摘要翻译： 本发明涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺在合成药物治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素和/或其它添加剂或稳定剂或佐剂，如维生素B，维生素C，NADH，NADPH和泛醌一起使用。本发明还涉及使用 的R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，以及它们的盐，酯和酰胺，用于制备治疗有限功能或降低的疾病的药物 葡萄糖转运蛋白的含量。
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3.发明授权Use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as its sequelae 失效R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 作为其后遗症
公开(公告)号：US6117899A
公开(公告)日：2000-09-12
申请号：US285460
申请日：1999-04-02
申请人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
发明人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
IPC分类号： C07D339/04 , A61K31/19 , A61K31/22 , A61K31/355 , A61K31/385 , A61K38/28 , A61P3/08 , A61P3/10
CPC分类号： A61K31/385 , A61K31/19 , A61K31/22 , A61K31/355 , Y10S514/866
摘要： The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone.The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.
摘要翻译： 本发明涉及使用R - （ - ） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺来合成用于治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素，和/或其它添加剂或稳定剂或佐剂如维生素E，维生素C，NADH，NADPH和泛醌一起使用。 本发明还涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物及其盐，酯和酰胺在制备用于治疗疾病的药物中的应用 葡萄糖转运蛋白的功能有限或含量降低。
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4.发明授权Use of R-(+)-.alpha.-lipoic acid, R-(-)dihydrolipoic acid and metabolites in the form of the free acid or salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae 失效R - （+） - α-硫辛酸，R - （ - ）二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 其后遗症
公开(公告)号：US5693664A
公开(公告)日：1997-12-02
申请号：US360924
申请日：1994-12-21
申请人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
发明人： Klaus Wessel , Harald Borbe , Heinz Ulrich , Helmut Hettche , Hans Bisswanger , Lester Packer , Amira Klip
IPC分类号： C07D339/04 , A61K31/19 , A61K31/22 , A61K31/355 , A61K31/385 , A61K38/28 , A61P3/08 , A61P3/10
CPC分类号： A61K31/385 , A61K31/19 , A61K31/22 , A61K31/355 , Y10S514/866
摘要： The invention relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin E, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-.alpha.-lipoic acid, R-(-)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.
摘要翻译： 本发明涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺用于合成药物治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素，和/或其它添加剂或稳定剂或佐剂如维生素E，维生素C，NADH，NADPH和泛醌一起使用。 本发明还涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物及其盐，酯和酰胺在制备用于治疗疾病的药物中的应用 葡萄糖转运蛋白的功能有限或含量降低。
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5.发明授权Pharmaceutical compositions containing R-&agr;-lipoic acid or S-&agr;-lipoic acid as active ingredient 失效含有R-α-硫辛酸或S-α-硫辛酸作为活性成分的药物组合物公开(公告)号：US06271254B1
公开(公告)日：2001-08-07
申请号：US09017409
申请日：1998-02-02
IPC分类号： A61K3140
CPC分类号： A61K47/10 , A61K9/0019 , A61K31/385 , A61K47/18
摘要： Pharmaceutical compositions and processes for their preparation containing R-&agr;-lipoic acid or S-&agr;-lipoic acid or pharmaceutically acceptable salts thereof. The pharmaceutical compositions have a cytoprotective activity and are suitable for combatting pain and inflammation.
摘要翻译： 含有R-α-硫辛酸或S-α-硫辛酸或其药学上可接受的盐的药物组合物及其制备方法。 药物组合物具有细胞保护活性，适用于对抗疼痛和炎症。
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6.发明授权Pharmaceutical composition containing R-.alpha.-lipoic acid or S-.alpha.-lipoic acid as active ingredient 失效含有α-硫辛酸或S-α-硫辛酸作为活性成分的药物组合物
公开(公告)号：US5728735A
公开(公告)日：1998-03-17
申请号：US794310
申请日：1997-02-03
IPC分类号： C07D339/04 , A61K31/385 , A61K47/10 , A61K47/18 , A61K31/20
CPC分类号： A61K47/10 , A61K31/385 , A61K47/18 , A61K9/0019
摘要： Pharmaceutical compositions and processes for their preparation containing R-.alpha.-lipoic acid or S-.alpha.-lipoic acid or pharmaceutically acceptable salts thereof. The pharmaceutical compositions have a cytoprotective activity and are suitable for combatting pain and inflammation.
摘要翻译： 含有α-硫辛酸或S-α-硫辛酸或其药学上可接受的盐的药物组合物及其制备方法。 药物组合物具有细胞保护活性，适用于对抗疼痛和炎症。
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7.发明授权Method of treating inflammatory diseases with pharmaceutical composition containing dihydrolipoic acid as active substance 失效用含有二氢胆酸的药物组合物作为活性物质治疗炎症疾病的方法
公开(公告)号：US5084481A
公开(公告)日：1992-01-28
申请号：US476042
申请日：1990-02-08
CPC分类号： A61K31/19 , A61K31/20 , Y10S514/886
摘要： Pharmaceutical compositions and their preparation which contain dihydrolipoic acid or its pharmaceutically acceptable salts as active substance. The pharmaceutical compositions have a cytoprotective effect and are suitable for combatting pain and inflammatory disorders.
摘要翻译： 含有二氢硫辛酸或其药学上可接受的盐作为活性物质的药物组合物及其制备。 药物组合物具有细胞保护作用，适用于对抗疼痛和炎症性疾病。
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8.发明授权Tablets, granulates and pellets with a high active substance content for highly concentrated, solid dosage forms 失效具有高活性物质含量的片剂，颗粒和丸剂用于高浓缩固体剂型
公开(公告)号：US5503845A
公开(公告)日：1996-04-02
申请号：US285145
申请日：1994-08-03
申请人： Joachim Goede , Jurgen Engel , Helmut Hettche
发明人： Joachim Goede , Jurgen Engel , Helmut Hettche
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K31/18 , A61K31/185 , A61K31/385 , A61K31/44 , A61P1/16 , A61P25/02
CPC分类号： A61K31/385 , A61K31/185 , A61K31/44 , A61K9/1652 , A61K9/2095
摘要： A solid medicinal form having an active substance content of over 45 weight % and a process for its preparation by granulating with large amounts of water, drying and optionally conventional tableting and/or pelleting.
摘要翻译： 具有超过45重量％的活性物质含量的固体药物形式和通过大量水制粒，干燥和任选常规压片和/或造粒制备的方法。
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9.发明授权Salts of azelastine having improved solubility effective at treating psoriasis and providing a cytoprotective effect 有权具有改善溶解性的阿伐斯他汀盐治疗银屑病并提供细胞保护作用
公开(公告)号：US6017909A
公开(公告)日：2000-01-25
申请号：US136971
申请日：1998-08-20
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.
摘要翻译： 萘曲宁与醋酸，葡萄糖酸，乳酸或苹果酸的盐。
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10.发明授权Salts of azelastine having improved solubility useful at providing a cytoprotective effect 失效具有改善的溶解度的氮卓斯汀的盐可用于提供细胞保护作用
公开(公告)号：US5998403A
公开(公告)日：1999-12-07
申请号：US123431
申请日：1998-07-28
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid, or malic acid. The azelastine salts are effective in providing a cytoprotective effect.
摘要翻译： 本发明涉及在水中具有改善的溶解性的氮卓斯汀盐。 本发明的盐通过使萘曲斯汀与乙酸，葡萄糖酸，乳酸或苹果酸反应来制备。 氮卓斯汀盐对提供细胞保护作用是有效的。
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