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    Use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae
    2.
    发明授权
    Use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid and metabolites in the form of the free acid or as salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae 失效
    R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸和游离酸形式的代谢物或盐或酯或酰胺用于制备治疗糖尿病的药物 作为其后遗症

    公开(公告)号：US06284787B1

    公开(公告)日：2001-09-04

    申请号：US09628295

    申请日：2000-07-28

    申请人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

    发明人： Klaus Wessel ,  Harald Borbe ,  Heinz Ulrich ,  Helmut Hettche ,  Hans Bisswanger ,  Lester Packer ,  Amira Klip

    IPC分类号： A61K31385

    CPC分类号： A61K31/385 ,  A61K31/19 ,  A61K31/22 ,  A61K31/355 ,  Y10S514/866

    摘要： The invention relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, salts, esters and amides for the synthesis of drugs for the treatment of diabetes mellitus of types I and II, compensated and decompensated insulin resistance and sequelae or late complications of diabetes mellitus, such as cataracts, polyneuropathy, nephropathy, as well as sequelae or late complications of insulin resistance. These drugs mentioned can also be used advantageously in combination with other antidiabetic drugs, particularly with insulin, and/or other additives or stabilizers or adjuvants, such as vitamin B, vitamin C, NADH, NADPH and ubiquinone. The invention furthermore relates to the use of R-(+)-&agr;-lipoic acid, R-(−)-dihydrolipoic acid or their metabolites, as well as their salts, esters and amides for the preparation of drugs for the treatment of diseases with limited function of or a lowered content of the glucose transporters.

    摘要翻译： 本发明涉及R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，盐，酯和酰胺在合成药物治疗I型糖尿病和 II，补偿和代偿失调的胰岛素抵抗和后遗症或糖尿病晚期并发症，如白内障，多发性神经病，肾病，以及胰岛素抵抗的后遗症或晚期并发症。 所提及的这些药物也可有利地与其它抗糖尿病药物，特别是与胰岛素和/或其它添加剂或稳定剂或佐剂，如维生素B，维生素C，NADH，NADPH和泛醌一起使用。本发明还涉及使用 的R - （+） - α-硫辛酸，R - （ - ） - 二氢硫辛酸或其代谢物，以及它们的盐，酯和酰胺，用于制备治疗有限功能或降低的疾病的药物 葡萄糖转运蛋白的含量。

    Combination medications containing alpha-lipoic acid and related
    6.
    发明授权
    Combination medications containing alpha-lipoic acid and related 失效
    含有α-硫辛酸和相关的组合药物

    公开(公告)号：US5569670A

    公开(公告)日：1996-10-29

    申请号：US404153

    申请日：1995-03-14

    申请人： Carl-Heinrich Weischer ,  Heinz Ulrich ,  Klaus Wessel

    发明人： Carl-Heinrich Weischer ,  Heinz Ulrich ,  Klaus Wessel

    IPC分类号： A61K31/385 ,  A61K31/44 ,  A61K31/51 ,  A61K31/525

    CPC分类号： A61K31/714 ,  A61K31/385 ,  A61K31/44 ,  A61K31/51 ,  A61K31/525 ,  Y10S514/866

    摘要： A pharmaceutical composition containing alpha-lipoic acid, dihydrolipoic acid, metabolites of alpha-lipoic acid (inter alia bisnortetralipoic acid and tetranorlipoic acid), optical isomers R- and S- forms of alpha-lipoic acid in oxidized and reduced form together with a vitamin, especially vitamins A, B1, B2, B6, B12, C and E and their pharmaceutically acceptable salts. The compositions are useful for producing analgesic, anti-inflammatory, antidiabetic, cytoprotective, anti-ulcer, antinecrotic, neuroprotective, detoxifying, anti-ischemic, liver function regulating, anti-allergic, immune-stimulating and antioncogenic effects.

    摘要翻译： 含有α-硫辛酸，二氢硫辛酸，α-硫辛酸（特别是二肉桂酸和四肉桂酸）的代谢物的药物组合物，氧化还原形式的α-硫辛酸的旋光异构体R-和S-形式以及维生素 特别是维生素A，B1，B2，B6，B12，C和E及其药学上可接受的盐。 该组合物可用于产生镇痛，抗炎，抗糖尿病，细胞保护，抗溃疡，抗坏死，神经保护，解毒，抗缺血，肝功能调节，抗过敏，免疫刺激和抗阴离子作用。

    Compositions comprising an NO donor and a dithiolane and their use for improvement of sexual function
    7.
    发明授权
    Compositions comprising an NO donor and a dithiolane and their use for improvement of sexual function 有权
    包含NO供体和二硫戊环的组合物及其用于改善性功能的用途

    公开(公告)号：US09107889B2

    公开(公告)日：2015-08-18

    申请号：US11568283

    申请日：2006-08-04

    申请人： Klaus Wessel

    发明人： Klaus Wessel

    IPC分类号： A61K31/198 ,  A61K31/385

    CPC分类号： A61K31/198 ,  A61K31/385

    摘要： The present invention relates to solid compositions comprising a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide or an direct or indirect NO agonist, with arginine being a preferred compound, in combination with a dithiolane, with α-lipoic acid as a preferred compound, and its use for improvement of sexual function. The compositions according to the invention comprise the NO donor or its precursor in excess, based on the molar amount of the constituents. The compositions are also suited for the improvement of sexual function. In particular the present invention relates to the use of a dithiolane in combination with a NO donor or a precursor thereof for the preparation of a medication for treatment of sexual dysfunction.

    摘要翻译： 本发明涉及包含改善一氧化氮（NO）可用性的物质的固体组合物， NO供体或一氧化氮或直接或间接NO激动剂的生物合成的前体，其中精氨酸是优选的化合物，与二硫戊环组合，与α-硫辛酸作为优选的化合物，其用于改善性 功能。 根据本发明的组合物基于组分的摩尔量包含NO供体或其前体过量。 该组合物也适用于改善性功能。 特别地，本发明涉及二硫戊环与NO供体或其前体组合用于制备用于治疗性功能障碍的药物的用途。

    Use of R(+)-alpha-lipoic acid for cryptogenic neuropathy
    8.
    发明授权
    Use of R(+)-alpha-lipoic acid for cryptogenic neuropathy 有权
    R（+） - α-硫辛酸用于隐源性神经病变

    公开(公告)号：US08722013B2

    公开(公告)日：2014-05-13

    申请号：US12673654

    申请日：2008-08-14

    申请人： Klaus Wessel

    发明人： Klaus Wessel

    IPC分类号： A61K49/00

    CPC分类号： A61K31/385

    摘要： The present invention relates to the use of R(+)-alpha-lipoic acid ((R)-5-(1,2-dithiolan-3-yl)valeric acid) and/or of a physiologically acceptable derivative of this compound for cryptogenic neuropathy.

    摘要翻译： 本发明涉及使用R（+） - α-硫辛酸（（R）-5-（1,2-二硫戊环-3-基）戊酸）和/或该化合物的生理上可接受的衍生物 隐源性神经病变

    Compositions Comprising An No Donor And A Dithiolane And Their Use For Improvement Of Sexual Function
    9.
    发明申请
    Compositions Comprising An No Donor And A Dithiolane And Their Use For Improvement Of Sexual Function 有权
    包括无供体和二硫戊环的组合及其用于改善性功能的用途

    公开(公告)号：US20080161381A1

    公开(公告)日：2008-07-03

    申请号：US11568283

    申请日：2006-08-04

    申请人： Klaus Wessel

    发明人： Klaus Wessel

    IPC分类号： A61K31/385 ,  A61P15/10

    CPC分类号： A61K31/198 ,  A61K31/385

    摘要： The present invention relates to solid compositions comprising a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide or an direct or indirect NO agonist, with arginine being a preferred compound, in combination with a dithiolane, with α-lipoic acid as a preferred compound, and its use for improvement of sexual function. The compositions according to the invention comprise the NO donor or its precursor in excess, based on the molar amount of the constituents. The compositions are also suited for the improvement of sexual function. In particular the present invention relates to the use of a dithiolane in combination with a NO donor or a precursor thereof for the preparation of a medication for treatment of sexual dysfunction.

    摘要翻译： 本发明涉及包含改善一氧化氮（NO）可用性的物质的固体组合物， NO供体或一氧化氮或直接或间接NO激动剂的生物合成的前体，其中精氨酸是优选的化合物，与二硫戊环组合，与α-硫辛酸作为优选的化合物，其用于改善性 功能。 根据本发明的组合物基于组分的摩尔量包含NO供体或其前体过量。 该组合物也适用于改善性功能。 特别地，本发明涉及二硫戊环与NO供体或其前体组合用于制备用于治疗性功能障碍的药物的用途。