-
11.发明授权Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods 有权脂质筏，窖蛋白和caveolar功能调节化合物及相关的合成和治疗方法公开(公告)号：US09132115B2
公开(公告)日：2015-09-15
申请号：US13867326
申请日：2013-04-22
申请人： Heidi Kay
发明人： Heidi Kay
IPC分类号： A61K31/282 , C07F15/00 , A61K9/00
CPC分类号： A61K31/282 , A61K9/0014 , A61K9/0019 , C07F15/0093
摘要： The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with cell transcription regulation, membrane and cellular transport, cell membrane receptor function, cellular trafficking, antigen presentation, cell differentiation and activation, cytokine modulation, membrane structure and function, and protein modulation. Caveolae, caveolin proteins and lipid rafts are known therapeutic targets for numerous biological functions. Diseases and disorders currently known to be therapeutically targeted through caveolae and/or lipid rafts include diabetes, cancer, cardiovascular diseases, atherosclerosis, pulmonary fibrosis, multiple sclerosis, viral and prion diseases, neuronal disorders, degenerative muscular dystrophies, and autoimmune disorders.
摘要翻译： 本发明涉及通过铂（IV）化合物调节脂筏，窖蛋白或caveolar功能和方法。 细胞膜蛋白和/或脂筏与细胞转录调节，膜和细胞转运，细胞膜受体功能，细胞运输，抗原呈递，细胞分化和激活，细胞因子调节，膜结构和功能以及蛋白质调节相关。 小窝蛋白，小窝蛋白和脂筏是许多生物功能的已知治疗靶标。 目前已知通过穴状病毒和/或脂筏治疗靶向的疾病和病症包括糖尿病，癌症，心血管疾病，动脉粥样硬化，肺纤维化，多发性硬化，病毒和朊病毒疾病，神经元疾病，退行性肌营养不良症和自身免疫性疾病。
-
公开(公告)号：US07977500B2
公开(公告)日：2011-07-12
申请号：US11667617
申请日：2005-11-10
申请人： Heidi Kay
发明人： Heidi Kay
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： The subject invention concerns biotin-conjugated platinum complexes that exhibit direct and indirect (immunological) antitumor cell activity. The subject invention also concerns the biotin-platinum complexes of the invention that have another molecule, such as an antibody, a ligand, a receptor, etc., bound to the biotin moiety. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
摘要翻译： 本发明涉及显示直接和间接（免疫）抗肿瘤细胞活性的生物素 - 缀合的铂络合物。 本发明还涉及具有与生物素部分结合的另一分子例如抗体，配体，受体等的本发明的生物素 - 铂络合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。
-
公开(公告)号：US07238372B2
公开(公告)日：2007-07-03
申请号：US10918762
申请日：2004-08-13
申请人： James Turkson , Richard Jove , Jay W. Palmer , Heidi Kay , Hua Yu
发明人： James Turkson , Richard Jove , Jay W. Palmer , Heidi Kay , Hua Yu
CPC分类号： C07F15/0093
摘要： The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
摘要翻译： 本发明涉及使用铂络合物抑制STAT生物学功能的方法。
-
14.发明授权Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods 有权脂质筏，窖蛋白和caveolar功能调节化合物及相关的合成和治疗方法公开(公告)号：US08026382B2
公开(公告)日：2011-09-27
申请号：US12122855
申请日：2008-05-19
申请人： Heidi Kay
发明人： Heidi Kay
CPC分类号： A61K31/282 , A61K9/0014 , A61K9/0019 , C07F15/0093
摘要： The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with cell transcription regulation, membrane and cellular transport, cell membrane receptor function, cellular trafficking, antigen presentation, cell differentiation and activation, cytokine modulation, membrane structure and function, and protein modulation. Caveolae, caveolin proteins and lipid rafts are known therapeutic targets for numerous biological functions. Diseases and disorders currently known to be therapeutically targeted through caveolae and/or lipid rafts include diabetes, cancer, cardiovascular diseases, atherosclerosis, pulmonary fibrosis, multiple sclerosis, viral and prion diseases, neuronal disorders, degenerative muscular dystrophies, and autoimmune disorders.
摘要翻译： 本发明涉及通过铂（IV）化合物调节脂筏，窖蛋白或caveolar功能和方法。 细胞膜蛋白和/或脂筏与细胞转录调节，膜和细胞转运，细胞膜受体功能，细胞运输，抗原呈递，细胞分化和激活，细胞因子调节，膜结构和功能以及蛋白质调节相关。 小窝蛋白，小窝蛋白和脂筏是许多生物功能的已知治疗靶标。 目前已知通过穴状病毒和/或脂筏治疗靶向的疾病和病症包括糖尿病，癌症，心血管疾病，动脉粥样硬化，肺纤维化，多发性硬化，病毒和朊病毒疾病，神经元疾病，退行性肌营养不良症和自身免疫性疾病。
-
公开(公告)号：US07977381B2
公开(公告)日：2011-07-12
申请号：US11703497
申请日：2007-02-07
申请人： Heidi Kay , Jay W. Palmer , Joseph A. Stanko , Said M. Sebti
发明人： Heidi Kay , Jay W. Palmer , Joseph A. Stanko , Said M. Sebti
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。
-
公开(公告)号：US07566798B2
公开(公告)日：2009-07-28
申请号：US10918769
申请日：2004-08-13
申请人： Heidi Kay , Jay W. Palmer , Joseph A. Stanko
发明人： Heidi Kay , Jay W. Palmer , Joseph A. Stanko
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。
-
17.发明申请Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods 有权脂质筏，窖蛋白和caveolar功能调节化合物及相关的合成和治疗方法公开(公告)号：US20080286316A1
公开(公告)日：2008-11-20
申请号：US12122855
申请日：2008-05-19
申请人： Heidi Kay
发明人： Heidi Kay
CPC分类号： A61K31/282 , A61K9/0014 , A61K9/0019 , C07F15/0093
摘要： The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with cell transcription regulation, membrane and cellular transport, cell membrane receptor function, cellular trafficking, antigen presentation, cell differentiation and activation, cytokine modulation, membrane structure and function, and protein modulation. Caveolae, caveolin proteins and lipid rafts are known therapeutic targets for numerous biological functions. Diseases and disorders currently known to be therapeutically targeted through caveolae and/or lipid rafts include diabetes, cancer, cardiovascular diseases, atherosclerosis, pulmonary fibrosis, multiple sclerosis, viral and prion diseases, neuronal disorders, degenerative muscular dystrophies, and autoimmune disorders.
摘要翻译： 本发明涉及通过铂（IV）化合物调节脂筏，窖蛋白或caveolar功能和方法。 细胞膜蛋白和/或脂筏与细胞转录调节，膜和细胞转运，细胞膜受体功能，细胞运输，抗原呈递，细胞分化和激活，细胞因子调节，膜结构和功能以及蛋白质调节相关。 小窝蛋白，小窝蛋白和脂筏是许多生物功能的已知治疗靶标。 目前已知通过穴状病毒和/或脂筏治疗靶向的疾病和病症包括糖尿病，癌症，心血管疾病，动脉粥样硬化，肺纤维化，多发性硬化，病毒和朊病毒疾病，神经元疾病，退行性肌营养不良症和自身免疫性疾病。
-
公开(公告)号：US20060010949A1
公开(公告)日：2006-01-19
申请号：US11127587
申请日：2005-05-12
申请人： Jay Palmer , Heidi Kay
发明人： Jay Palmer , Heidi Kay
IPC分类号： C05G3/00
摘要： Several compositions of matter have been discovered that can be used in the manufacture of slow-release fertilizers that contain all of the essential elements needed by plants and humans. Slow-release fertilizers manufactured with these formulations can be used on mineral stressed soils to increase the quality and production of food crops grown on them. Additives, including phosphogypsum, silica sand, natural gypsum, clay, and coal dust, facilitate the timing of the release of the essential elements into the soil.
摘要翻译： 已经发现几种物质组合物可用于制备包含植物和人类所需的所有必需元素的缓释肥料。 用这些制剂制造的缓释肥料可用于矿物应激土壤，以提高种植在其上的粮食作物的质量和产量。 添加剂，包括磷石膏，硅砂，天然石膏，粘土和煤粉，有助于将基本元素释放到土壤中的时机。
-
19.发明申请公开(公告)号：US20050288365A1
公开(公告)日：2005-12-29
申请号：US11030567
申请日：2005-01-06
申请人： Heidi Kay , Jay Palmer , Joseph Stanko , Said Sebti
发明人： Heidi Kay , Jay Palmer , Joseph Stanko , Said Sebti
CPC分类号： C07F15/0093
摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.
摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。
-
公开(公告)号：US08598230B2
公开(公告)日：2013-12-03
申请号：US12837046
申请日：2010-07-15
申请人： James Turkson , Richard Jove , Jay Palmer , Heidi Kay , Hua Yu
发明人： James Turkson , Richard Jove , Jay Palmer , Heidi Kay , Hua Yu
IPC分类号： A61K31/28
CPC分类号： C07F15/0093
摘要： The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
摘要翻译： 本发明涉及使用铂络合物抑制STAT生物学功能的方法。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.022 秒)
