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26 条记录 (耗时 0.016 秒)

    Platinum complexes and methods for inhibiting tumor cell proliferation
    1.
    发明授权
    Platinum complexes and methods for inhibiting tumor cell proliferation 有权
    铂复合物和抑制肿瘤细胞增殖的方法

    公开(公告)号：US08455543B2

    公开(公告)日：2013-06-04

    申请号：US13158060

    申请日：2011-06-10

    申请人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko ,  Said M. Sebti

    发明人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko ,  Said M. Sebti

    IPC分类号： C07F15/00

    CPC分类号： C07F15/0093

    摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

    摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。

    Platinum complexes and methods of use
    2.
    发明授权
    Platinum complexes and methods of use 有权
    铂金配合物和使用方法

    公开(公告)号：US08247445B2

    公开(公告)日：2012-08-21

    申请号：US12835114

    申请日：2010-07-13

    申请人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    发明人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    IPC分类号： C07F15/00 ,  A61K31/28

    CPC分类号： C07F15/0093

    摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

    摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。

    Platinum complexes and methods of use
    3.
    发明授权
    Platinum complexes and methods of use 失效
    铂金配合物和使用方法

    公开(公告)号：US07759510B2

    公开(公告)日：2010-07-20

    申请号：US12506913

    申请日：2009-07-21

    申请人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    发明人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    IPC分类号： C07F15/00 ,  A61K31/28

    CPC分类号： C07F15/0093

    摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

    摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物体内或体外的感染。

    Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods
    4.
    发明授权
    Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods 有权

    公开(公告)号：US08425921B1

    公开(公告)日：2013-04-23

    申请号：US13245279

    申请日：2011-09-26

    申请人： Heidi Kay

    发明人： Heidi Kay

    IPC分类号： A61K45/00 ,  A61K31/28 ,  C07F15/00

    CPC分类号： A61K31/282 ,  A61K9/0014 ,  A61K9/0019 ,  C07F15/0093

    摘要： The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with cell transcription regulation, membrane and cellular transport, cell membrane receptor function, cellular trafficking, antigen presentation, cell differentiation and activation, cytokine modulation, membrane structure and function, and protein modulation. Caveolae, caveolin proteins and lipid rafts are known therapeutic targets for numerous biological functions. Diseases and disorders currently known to be therapeutically targeted through caveolae and/or lipid rafts include diabetes, cancer, cardiovascular diseases, atherosclerosis, pulmonary fibrosis, multiple sclerosis, viral and prion diseases, neuronal disorders, degenerative muscular dystrophies, and autoimmune disorders.

    Slow-release (GSSP) fertilizer
    6.
    发明授权
    Slow-release (GSSP) fertilizer 有权
    缓释（GSSP）肥料

    公开(公告)号：US07731775B2

    公开(公告)日：2010-06-08

    申请号：US11127587

    申请日：2005-05-12

    申请人： Jay W. Palmer ,  Heidi Kay

    发明人： Jay W. Palmer ,  Heidi Kay

    IPC分类号： C05C9/00

    CPC分类号： C05B1/04 ,  C05B3/00 ,  C05C9/00 ,  C05D1/02 ,  C05D5/00 ,  C05D9/02

    摘要： Several compositions of matter have been discovered that can be used in the manufacture of slow-release fertilizers that contain all of the essential elements needed by plants and humans. Slow-release fertilizers manufactured with these formulations can be used on mineral stressed soils to increase the quality and production of food crops grown on them. Additives, including phosphogypsum, silica sand, natural gypsum, clay, and coal dust, facilitate the timing of the release of the essential elements into the soil.

    摘要翻译： 已经发现几种物质组合物可用于制备包含植物和人类所需的所有必需元素的缓释肥料。 用这些制剂制造的缓释肥料可用于矿物应激土壤，以提高种植在其上的粮食作物的质量和产量。 添加剂，包括磷石膏，硅砂，天然石膏，粘土和煤粉，有助于将基本元素释放到土壤中的时机。

    Platinum Complexes and Methods of Use
    7.
    发明申请
    Platinum Complexes and Methods of Use 失效
    铂配合物和使用方法

    公开(公告)号：US20090285884A1

    公开(公告)日：2009-11-19

    申请号：US12506913

    申请日：2009-07-21

    申请人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    发明人： Heidi Kay ,  Jay W. Palmer ,  Joseph A. Stanko

    IPC分类号： A61K9/127 ,  C07F15/00 ,  A61K31/28 ,  A61K31/555 ,  A61K31/665 ,  A61P31/04

    CPC分类号： C07F15/0093

    摘要： The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

    摘要翻译： 本发明涉及显示抗肿瘤细胞和/或抗寄生虫活性的铂配合物。 本发明还涉及使用本发明的铂络合物来治疗肿瘤和炎性疾病。 本发明的铂络合物还可用于治疗或预防病毒或细菌或寄生生物在体内或体外的感染。

    Utilities of stimulated whole blood culture systems
    9.
    发明授权
    Utilities of stimulated whole blood culture systems 有权

    公开(公告)号：US11926861B2

    公开(公告)日：2024-03-12

    申请号：US16779807

    申请日：2020-02-03

    申请人： Heidi Kay

    发明人： Heidi Kay

    IPC分类号： C12Q1/06 ,  C12Q1/02

    CPC分类号： C12Q1/06 ,  C12Q1/025

    摘要： The invention describes a method for determining how to stimulate, monitor and/or inhibit virus production in whole blood culture. The invention relates to a test kit for performing the method and to the use of a suitable blood sampling system. The system can be used to determine how to activate or target latently HIV-infected cells, for clinical management of HIV treatments and for personalized therapeutic strategies.

    Utilities of stimulated whole blood culture systems
    10.
    发明授权
    Utilities of stimulated whole blood culture systems 有权

    公开(公告)号：US10550419B2

    公开(公告)日：2020-02-04

    申请号：US14208086

    申请日：2014-03-13

    申请人： Heidi Kay

    发明人： Heidi Kay

    IPC分类号： C12Q1/06 ,  C12Q1/02

    摘要： The invention describes a method for determining how to stimulate, monitor and/or inhibit virus production in whole blood culture. The invention relates to a test kit for performing the method and to the use of a suitable blood sampling system. The system can be used to determine how to activate or target latently HIV-infected cells, for clinical management of HIV treatments and for personalized therapeutic strategies.