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公开(公告)号：US6043226A
公开(公告)日：2000-03-28
申请号：US257709
申请日：1999-02-25
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61P31/00 , A61P31/04 , A61P33/00 , A61P35/00 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08
摘要： This invention relates to compounds of formulas 1 and 2 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein X, X.sup.1, R.sup.1, R.sup.2, R.sup.7, R.sup.17 and R.sup.19 are as defined herein. The compounds of formulas 1 and 2 may be useful in the treatment of bacterial, parasitic and protozoal infections, as well as disorders related to bacterial, parasitic and protozoal infections, in mammals, fish and birds. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and 2 and to methods of treating bacterial, parasitic and protozoal infections by administering the compounds of formula 1 and 2.
摘要翻译： 本发明涉及式1和式2的化合物及其药学上可接受的盐和溶剂合物，其中X，X 1，R 1，R 2，R 7，R 17和R 19如本文所定义。 式1和2的化合物可用于治疗细菌，寄生虫和原生动物感染以及与哺乳动物，鱼和鸟类中的细菌，寄生虫和原生动物感染有关的疾病。 本发明还涉及含有式1和2化合物的药物组合物以及通过施用式1和式2化合物来治疗细菌，寄生虫和原生动物感染的方法。
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![IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS](/abs-image/US/2011/08/04/US20110190326A1/abs.jpg.150x150.jpg)
12.发明申请IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS 有权咪达唑[1,5]萘啶化合物，其药物用途和组合物公开(公告)号：US20110190326A1
公开(公告)日：2011-08-04
申请号：US13121900
申请日：2009-09-18
IPC分类号： A61K31/4709 , C07D471/22 , A61K31/506 , A61P35/00
CPC分类号： C07D471/14
摘要： The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-Kα inhibitors and/or PI3-Kα/mTOR dual inhibitors.
摘要翻译： 本发明涉及式（I）化合物及其盐，其合成及其作为PI3-Kα抑制剂和/或PI3-Kα/ mTOR双重抑制剂的用途。
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公开(公告)号：US07732604B2
公开(公告)日：2010-06-08
申请号：US11745921
申请日：2007-05-08
申请人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dubé
发明人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dubé
IPC分类号： C07D471/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号：US20100105656A1
公开(公告)日：2010-04-29
申请号：US12651984
申请日：2010-01-04
申请人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dubé
发明人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dubé
IPC分类号： A61K31/397 , A61K31/551 , A61K31/5377 , A61K31/4985 , A61P35/02 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 4如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号：US20070265272A1
公开(公告)日：2007-11-15
申请号：US11745921
申请日：2007-05-08
申请人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dube
发明人： Hengmiao Cheng , Jingrong Jean Cui , Jacqui Elizabeth Hoffman , Lei Jia , Mary Catherine Johnson , Robert Steven Kania , Phuong Thi Quy Le , Mitchell David Nambu , Mason Alan Pairish , Hong Shen , Michelle Bich Tran-Dube
IPC分类号： A61K31/495 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 2 > 4 如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号：US06727352B2
公开(公告)日：2004-04-27
申请号：US10226760
申请日：2002-08-23
申请人： Hengmiao Cheng , Chao Li
发明人： Hengmiao Cheng , Chao Li
IPC分类号： C07H100
摘要： This invention relates to methods of preparing a compound of Formulae 2, 5 and 7, wherein R2-R5, R7, R9, R10 and R15 are defined herein.
摘要翻译： 本发明涉及制备式2,5和7化合物的方法，其中R 2 -R 5，R 7，R 9，R 10和R 15如本文所定义 。
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公开(公告)号：US09040547B2
公开(公告)日：2015-05-26
申请号：US13617035
申请日：2012-09-14
申请人： Hengmiao Cheng , Theodore Otto Johnson, Jr. , John Charles Kath , Kevin Kun-Chin Liu , Elizabeth Ann Lunney , Asako Nagata , Sajiv Krishnan Nair , Simon Paul Planken , Scott Channing Sutton
发明人： Hengmiao Cheng , Theodore Otto Johnson, Jr. , John Charles Kath , Kevin Kun-Chin Liu , Elizabeth Ann Lunney , Asako Nagata , Sajiv Krishnan Nair , Simon Paul Planken , Scott Channing Sutton
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/52 , C07D473/16 , C07D487/04
CPC分类号： C07D487/04 , C07D473/18 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中Q，T，V，W，X，Y，Z，环A，R1，R2，R3，R4，R5，R5a，R6，R7 ，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15，R 16，R 17和m如本文所定义。 有新的吡咯并嘧啶和嘌呤衍生物可用于哺乳动物治疗异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。
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公开(公告)号：US20130079324A1
公开(公告)日：2013-03-28
申请号：US13617035
申请日：2012-09-14
申请人： Hengmiao Cheng , Theodore Otto Johnson, JR. , John Charles Kath , Kevin Kun-Chin Liu , Elizabeth Ann Lunney , Asako Nagata , Sajiv Krishnan Nair , Simon Paul Planken , Scott Channing Sutton
发明人： Hengmiao Cheng , Theodore Otto Johnson, JR. , John Charles Kath , Kevin Kun-Chin Liu , Elizabeth Ann Lunney , Asako Nagata , Sajiv Krishnan Nair , Simon Paul Planken , Scott Channing Sutton
IPC分类号： A61K31/519 , C07D473/18 , A61P35/00 , A61K31/5377 , C07D498/10 , A61K31/5386 , C07D487/04 , A61K31/52
CPC分类号： C07D487/04 , C07D473/18 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
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公开(公告)号：US07482368B2
公开(公告)日：2009-01-27
申请号：US11196563
申请日：2005-08-02
申请人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/44
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译： 本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如说明书中所定义，以及其药物组合物及其用途，以及制备该化合物的方法。 本发明的化合物可用于治疗肥胖症和脂质疾病。
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公开(公告)号：US20050288335A1
公开(公告)日：2005-12-29
申请号：US11196563
申请日：2005-08-02
申请人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/341 , A61K31/343 , A61K31/397 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4439 , A61K31/4525 , A61K31/4709 , A61K31/501 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D209/42 , C07D307/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
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