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公开(公告)号：US06720351B2
公开(公告)日：2004-04-13
申请号：US10177858
申请日：2002-06-20
申请人： Peter Bertinato , Alan E. Blize , Brian S. Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan E. Blize , Brian S. Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31405
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译： 本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如本说明书中所定义，以及其药物组合物及其用途，以及制备该化合物的方法。 本发明的化合物可用于治疗肥胖症和脂质疾病。
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公开(公告)号：US07348355B2
公开(公告)日：2008-03-25
申请号：US11351571
申请日：2006-02-10
申请人： Peter Bertinato , Alan E. Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan E. Blize , Brian Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译： 本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如本说明书中所定义，以及其药物组合物及其用途，以及 制备化合物的方法。 本发明的化合物可用于治疗肥胖症和脂质疾病。
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公开(公告)号：US06979692B2
公开(公告)日：2005-12-27
申请号：US10639854
申请日：2003-08-13
申请人： Peter Bertinato , Alan E. Blize , Brian S. Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Alan E. Blize , Brian S. Bronk , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/341 , A61K31/343 , A61K31/397 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4439 , A61K31/4525 , A61K31/4709 , A61K31/501 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D209/42 , C07D307/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/44 , A61P3/00 , C07D213/28
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译： 本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如本说明书中所定义，以及其药物组合物及其用途，以及 制备化合物的方法。 本发明的化合物可用于治疗肥胖症和脂质疾病。
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公开(公告)号：US06329345B1
公开(公告)日：2001-12-11
申请号：US09442530
申请日：1999-11-18
申请人： Robert J. Rafka , Barry J. Morton , Colman B. Ragan , Peter Bertinato , John P. Dirlam , Alan E. Blize , Carl B. Ziegler
发明人： Robert J. Rafka , Barry J. Morton , Colman B. Ragan , Peter Bertinato , John P. Dirlam , Alan E. Blize , Carl B. Ziegler
IPC分类号： A61K3170
CPC分类号： C07H17/08 , A61K31/7052 , C07H17/00
摘要： The invention relates to a method of preparing compounds of the formula 1 and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial protozoa infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.
摘要翻译： 本发明涉及制备式1化合物及其药学上可接受的盐的方法。 式1的化合物是可用于治疗各种细菌和原生动物感染的抗菌剂。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物来治疗细菌原生动物感染的方法。本发明还涉及制备式1化合物的方法和用于此类制备的中间体。
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公开(公告)号：US07482368B2
公开(公告)日：2009-01-27
申请号：US11196563
申请日：2005-08-02
申请人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Brian Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/44
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
摘要翻译： 本发明涉及式1的三酰胺MTP / ApoB抑制剂，其中R 1 -R 8如说明书中所定义，以及其药物组合物及其用途，以及制备该化合物的方法。 本发明的化合物可用于治疗肥胖症和脂质疾病。
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公开(公告)号：US06949572B2
公开(公告)日：2005-09-27
申请号：US10639855
申请日：2003-08-13
申请人： Peter Bertinato , Brian S. Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
发明人： Peter Bertinato , Brian S. Bronk , Alan E. Blize , Hengmiao Cheng , Jin Li , Hiep Huatan , Clive Mason
IPC分类号： A61K31/341 , A61K31/343 , A61K31/397 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4439 , A61K31/4525 , A61K31/4709 , A61K31/501 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00 , C07D209/42 , C07D307/85 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/44 , A61P3/00 , C07D40/00
CPC分类号： C07D401/12 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4439 , A61K31/655 , C07D209/42 , C07D307/85 , C07D401/14 , C07D405/12 , C07D409/12
摘要： The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
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