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    Feline cytokine protein
    12.
    发明授权
    Feline cytokine protein 失效
    猫细胞因子蛋白

    公开(公告)号：US06472509B1

    公开(公告)日：2002-10-29

    申请号：US09011143

    申请日：1998-02-04

    申请人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

    发明人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

    IPC分类号： C07K1400

    CPC分类号： C07K14/52 ,  A61K38/00

    摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).

    摘要翻译： 一种具有增强猫细胞毒性T淋巴细胞的细胞毒性活性，编码所述蛋白质的DNA序列，表达所述蛋白质的重组DNA，包含所述重组DNA的表达载体的活性的新型猫科动物细胞因子蛋白， 表达载体，通过培养所述转化体制备所述蛋白质的方法和针对所述蛋白质的抗体。 本发明的新型猫科动物细胞因子蛋白是包含FLAF p35和FLAF p40的异源二聚体，可用于治疗猫感染性疾病如1型（FHV-1）或猫杯状病毒（FCV）。

    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
    13.
    发明授权
    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand 有权
    与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域

    公开(公告)号：US06777540B1

    公开(公告)日：2004-08-17

    申请号：US09254180

    申请日：1999-04-15

    申请人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    发明人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    IPC分类号： C07K1600

    CPC分类号： C07K16/2875 ,  C07K14/70575 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

    摘要： Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.

    摘要翻译： 提供了与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段，证明了Fas配体上对Fas-Fas配体与Fas表达细胞相互作用诱导的细胞凋亡重要的位点。 通过重组DNA技术从与Fas配体特异性反应的单克隆抗体的杂交瘤制备与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段。 人源化免疫球蛋白可以抑制Fas配体和Fas之间的生理反应，如细胞凋亡。 此外，鉴定在Fas配体上并负责细胞凋亡诱导的位点允许产生对位点内的氨基酸具有特异性反应性的重组蛋白质或肽，以便抑制细胞凋亡，并找到新的治疗剂或诊断剂。

    MEDICAL ADHESIVE
    14.
    发明申请
    MEDICAL ADHESIVE 有权
    医用胶粘剂

    公开(公告)号：US20140018510A1

    公开(公告)日：2014-01-16

    申请号：US14005906

    申请日：2012-03-09

    申请人： Naoaki Kawakami ,  Hiroaki Maeda

    发明人： Naoaki Kawakami ,  Hiroaki Maeda

    IPC分类号： A61L24/04

    CPC分类号： A61L24/046 ,  C08G18/4837 ,  C08G18/4845 ,  C08G18/773 ,  C09J175/04 ,  C09J175/08 ,  C08L75/04

    摘要： The present invention is directed to providing a safe medical adhesive, a cured body of which is hard to be degraded and decomposed and thus stable and the cured body generates less amount of acid, aldehyde, etc. due to degradation/decomposition. The medical adhesive includes a hydrophilic urethane prepolymer (UP) obtained by reacting a polyisocyanate component (A) containing a fluorine-containing non-aromatic polyisocyanate compound (A1) as an essential ingredient and a polyol component (B) containing a hydrophilic polyol (B1) as an essential ingredient, wherein a chlorine content in a chlorine-containing organic compound based on the weight of the hydrophilic urethane prepolymer (UP) is 0.005 wt % or less.

    摘要翻译： 本发明旨在提供一种安全的医用粘合剂，其固化体难以降解和分解，因此稳定，固化体由于降解/分解而产生较少量的酸，醛等。 医用胶粘剂包括通过使含有含氟非芳香族多异氰酸酯化合物（A1）作为必需成分的多异氰酸酯成分（A）与含有亲水性多元醇（B1）的多元醇成分（B）反应而得到的亲水性氨基甲酸酯预聚物（UP） ）作为必要成分，其中，基于亲水性氨基甲酸酯预聚物（UP）的重量，含氯有机化合物中的氯含量为0.005重量％以下。

    IMAGE FORMING APPARATUS AND CONTROLLING METHOD
    17.
    发明申请
    IMAGE FORMING APPARATUS AND CONTROLLING METHOD 有权
    图像形成装置和控制方法

    公开(公告)号：US20100209127A1

    公开(公告)日：2010-08-19

    申请号：US12700064

    申请日：2010-02-04

    申请人： Tomonari HOKKYOH ,  Hiroaki Maeda ,  Katsuhiro Akinaga ,  Koutarou Yamada

    发明人： Tomonari HOKKYOH ,  Hiroaki Maeda ,  Katsuhiro Akinaga ,  Koutarou Yamada

    IPC分类号： G03G15/08

    CPC分类号： G03G15/09 ,  G03G15/5008

    摘要： The disclosed image forming apparatus includes a rotatable image holding body configured to hold an electrostatic latent image on a surface of the image holding body, a developing device including a forward rotation developing roller rotatable in a same rotational direction as that of the rotatable image holding body and a reverse rotation developing roller rotatable in a reverse rotational direction to that of the rotatable image holding body, which supply a two-component developer to the surface of the image holding body to form a toner image corresponding to the electrostatic latent image, and a control unit configured to control rotation of the image holding body, the forward rotation developing roller, and the reverse rotation developing roller to supply the two-component developer. The control unit controls the rotation of the image holding body to start after a predetermined time period from starting the rotation of the forward rotation developing roller and the reverse rotation developing roller.

    摘要翻译： 所公开的图像形成装置包括：可旋转图像保持体，其构造成将静电潜像保持在图像保持体的表面上;显影装置，包括可旋转的旋转图像保持体的旋转方向的正转显影辊 以及反转显影辊，其以与可旋转图像保持体相反的旋转方向旋转，将双组分显影剂供应到图像保持体的表面，以形成与静电潜像对应的调色剂图像;以及 控制单元，被配置为控制图像保持体，正向旋转显影辊和反转显影辊的旋转，以供应双组分显影剂。 控制单元控制图像保持体的旋转，以在从正向旋转显影辊和反转显影辊的旋转开始的预定时间段之后开始。