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13 条记录 (耗时 0.025 秒)

    Measuring apparatus
    11.
    发明授权
    Measuring apparatus 有权
    测量装置

    公开(公告)号：US07530277B2

    公开(公告)日：2009-05-12

    申请号：US11668248

    申请日：2007-01-29

    申请人： Takao Miyasaka ,  Akihiro Nagai ,  Yusaku Miyata ,  Tomoyuki Inoue

    发明人： Takao Miyasaka ,  Akihiro Nagai ,  Yusaku Miyata ,  Tomoyuki Inoue

    IPC分类号： G01N3/02

    CPC分类号： G01R15/186 ,  G01R1/04 ,  G01R1/22

    摘要： A measuring apparatus has a display unit that can be favorably viewed when a measured object is clamped by a clamp-type sensor regardless of the orientation and position of the measured object. The measuring apparatus includes a first main unit on which the clamp-type sensor is disposed and a second main unit that is rotatably connected to the first main unit and on which the display unit is disposed. The second main unit is connected to the first main unit via a hinge unit capable of maintaining an arbitrary rotation position. The display unit is disposed on a surface of the second main unit that is opposite the first main unit when the measuring apparatus is folded up.

    摘要翻译： 测量装置具有显示单元，当测量对象被夹持型传感器夹紧时，无论测量对象的取向和位置如何，都可以有利地观看。 测量装置包括：第一主单元，夹具式传感器设置在该第一主单元上，第二主单元可旋转地连接到第一主单元，显示单元设置在该第一主单元上。 第二主单元经由能够保持任意旋转位置的铰链单元连接到第一主单元。 当测量装置折叠时，显示单元设置在与第一主单元相对的第二主单元的表面上。

    Method of producing highly water-soluble cyclodextrin complex
    12.
    发明授权
    Method of producing highly water-soluble cyclodextrin complex 失效
    生产高度水溶性环糊精复合物的方法

    公开(公告)号：US5536623A

    公开(公告)日：1996-07-16

    申请号：US011457

    申请日：1993-01-29

    申请人： Yoshihiro Ohmachi ,  Yoshihiko Tsugawa ,  Akihiro Nagai

    发明人： Yoshihiro Ohmachi ,  Yoshihiko Tsugawa ,  Akihiro Nagai

    IPC分类号： A61K47/48 ,  C08B37/16

    CPC分类号： B82Y5/00 ,  A61K47/48969

    摘要： The present invention provides 1) a method of producing a complex of a fumagillol derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen; R.sup.2 is halogen, N(O)mR.sup.5 R.sup.6, N+R.sup.5 R.sup.6 R.sup.7.X-- or S(O)nR.sup.5, wherein R.sup.5, R.sup.6 and R.sup.7 are independently an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X-- is a counter anion; m is 0 or 1; n is an integer of 0 to 2; and R.sup.5 and R.sup.6 together with the adjacent nitrogen or sulfur atom may form an optionally substituted nitrogen- or sulfur-containing heterocyclic group which may form a condensed ring; or R.sup.1 and R.sup.2 are combined to represent a chemical bond; R.sup.3 is 2-methyl-1-propenyl group or isobutyl group; A is oxygen or NR.sup.8, wherein R.sup.8 is hydrogen or an optionally substituted lower alkyl or aryl group; and R.sup.4 is hydrogen, an optionally substituted hydrocarbon group or an optionally substituted acyl group; or a physiologically acceptable salt thereof, with a highly water-soluble cyclodextrin derivative, which comprises mixing the fumagillol derivative or a physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative into an aqueous solution, the concentration of the highly water-soluble cyclodextrin derivative being at about 100 mg/ml or more, and 2) the complex of the fumaggillol derivative (I) or physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative obtained by the production method 1).The complex of the fumagillol derivative (I) or physiologically acceptable salt thereof with the highly water-soluble cyclodextrin derivative is highly soluble in water, highly stable in storage and can be used as a preparation for injection.

    摘要翻译： 本发明提供1）制备下式的烟曲霉醇衍生物的复合物的方法：其中R 1是氢; R2是卤素，N（O）mR5R6，N + R5R6R7.X-或S（O）nR5，其中R5，R6和R7独立地是任选取代的烃基或任选取代的杂环基; X-是抗衡阴离子; m为0或1; n为0〜2的整数， 并且R 5和R 6与相邻的氮或硫原子一起可以形成可以形成稠环的任选取代的含氮或含硫杂环基; 或R1和R2组合以表示化学键; R3是2-甲基-1-丙烯基或异丁基; A是氧或NR8，其中R8是氢或任选取代的低级烷基或芳基; 且R 4为氢，任选取代的烃基或任选取代的酰基; 或其生理上可接受的盐与高度水溶性的环糊精衍生物组合，其包括将烟曲霉醇衍生物或其生理学上可接受的盐与高度水溶性环糊精衍生物混合到水溶液中，高度水溶性环糊精的浓度 衍生物为约100mg / ml以上，以及2）烟曲霉衍生物（I）或其生理学上可接受的盐与通过制备方法1）获得的高度水溶性环糊精衍生物的络合物。 烟曲霉醇衍生物（I）或其生理学上可接受的盐与高度水溶性环糊精衍生物的络合物高度可溶于水，储存高度稳定，可用作注射剂。