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13 条记录 (耗时 0.02 秒)

    Production of microspheres
    4.
    发明授权
    Production of microspheres 失效
    生产微球

    公开(公告)号：US5851451A

    公开(公告)日：1998-12-22

    申请号：US766611

    申请日：1996-12-13

    申请人： Nobuyuki Takechi ,  Seiji Ohtani ,  Akihiro Nagai

    发明人： Nobuyuki Takechi ,  Seiji Ohtani ,  Akihiro Nagai

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/52

    CPC分类号： A61K9/1647 ,  A61K9/1694 ,  Y10S514/937 ,  Y10S514/938

    摘要： Disclosed is a method of producing microspheres which comprises subjecting a w/o/w emulsion or o/w emulsion to an in-water drying method under the following conditions: 1) the amount of microspheres per m.sup.3 of an external aqueous phase is about 0.1 to about 500 kg, 2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of an external aqueous phase, 3) the w/o/w emulsion or o/w emulsion is replaced at the replacement frequency of about 0.01 to about 10 times/minutes, 4) a gas is blown to the w/o/w emulsion or o/w emulsion at the gas transfer rate near the liquid surface of about 0.1 to about 300 m/second, and 5) the gas is replaced at the replacement frequency of not less than about 0.5 times/minutes; and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.

    摘要翻译： 公开了一种制备微球体的方法，其包括在以下条件下使w / o / w乳液或o / w乳液进行水中干燥方法：1）每m3外部水相的微球体的量为约0.1至 约500kg，2）与气相接触的液面的面积（单位：m2）的平方根相对于外部水相的体积的立方根（单位：m3）为约0.2〜约4.5 ，3）w / o / w乳液或o / w乳液以约0.01至约10次/分钟的替换频率替换，4）将气体吹入w / o / w乳液或o / w乳液 在液体表面附近的气体传输速率为约0.1至约300m /秒，以及5）以不小于约0.5次/分钟的替换频率更换气体; 并且本发明的方法增加了水中干燥中微球溶剂去除速率，在短时间内减少了微球中的溶剂量。

    Sustained release microspheres and preparation thereof
    6.
    发明授权
    Sustained release microspheres and preparation thereof 有权
    缓释微球及其制备方法

    公开(公告)号：US6036976A

    公开(公告)日：2000-03-14

    申请号：US154164

    申请日：1998-09-16

    申请人： Nobuyuki Takechi ,  Seiji Ohtani ,  Akihiro Nagai

    发明人： Nobuyuki Takechi ,  Seiji Ohtani ,  Akihiro Nagai

    IPC分类号： A61K9/16 ,  A61K9/42

    CPC分类号： A61K9/1647 ,  A61K9/1694 ,  Y10S514/937 ,  Y10S514/938

    摘要： Disclosed is a method of producing microspheres which comprises subjecting a w/o/w emulsion or o/w emulsion to an in-water drying method under the following conditions:1) the amount of microspheres per m.sup.3 of an external aqueous phase is about 0.1 to about 500 kg,2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of an external aqueous phase,3) the w/o/w emulsion or o/w emulsion is replaced at the replacement frequency of about 0.01 to about 10 times/minutes,4) a gas is blown to the w/o/w emulsion or o/w emulsion at the gas transfer rate near the liquid surface of about 0.1 to about 300 m/second, and5) the gas is replaced at the replacement frequency of not less than about 0.5 times/minutes;and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.

    摘要翻译： 公开了一种制备微球体的方法，其包括在以下条件下使w / o / w乳液或o / w乳液进行水中干燥方法：1）每m3外部水相的微球体的量为约0.1至 约500kg，2）与气相接触的液面的面积（单位：m2）的平方根相对于外部水相的体积的立方根（单位：m3）为约0.2〜约4.5 ，3）w / o / w乳液或o / w乳液以约0.01至约10次/分钟的替换频率替换，4）将气体吹入w / o / w乳液或o / w乳液 在液体表面附近的气体传输速率为约0.1至约300m /秒，以及5）以不小于约0.5次/分钟的替换频率更换气体; 并且本发明的方法增加了水中干燥中微球溶剂去除速率，在短时间内减少了微球中的溶剂量。

    Pharmaceutical composition
    7.
    发明授权
    Pharmaceutical composition 失效
    药物组成

    公开(公告)号：US5536735A

    公开(公告)日：1996-07-16

    申请号：US322485

    申请日：1994-10-14

    申请人： Nobuyuki Takechi ,  Akihiro Nagai ,  Naoru Hamaguchi

    发明人： Nobuyuki Takechi ,  Akihiro Nagai ,  Naoru Hamaguchi

    IPC分类号： A61K31/44 ,  A61K47/18 ,  A61K47/22

    CPC分类号： A61K47/18 ,  A61K31/44 ,  A61K47/22 ,  A61K9/0019

    摘要： This invention comprises a pharmaceutical composition comprising a benzimidazole compound having antiulcer activity and a water-soluble carboxylic acid amide. According to this invention, a water-insoluble benzimidazole compound having antiulcer activity can be solubilized and a stable pharmaceutical composition can be provided. The solid pharmaceutical composition of this invention can be extemporaneously dissolved in sterile distilled water or an infusion (e.g. physiological saline, glucose infusion, etc.) and put to use as an injection with great convenience.

    摘要翻译： 本发明包括含有具有抗溃疡活性的苯并咪唑化合物和水溶性羧酸酰胺的药物组合物。 根据本发明，可以溶解具有抗溃疡活性的水不溶性苯并咪唑化合物，并且可以提供稳定的药物组合物。 本发明的固体药物组合物可以临时溶解于无菌蒸馏水或输液（例如生理盐水，葡萄糖输注等）中，并极大地方便地用作注射剂。

    Injectable solution containing a pyridyl methylsulfinylbenzimidazole
    8.
    发明授权
    Injectable solution containing a pyridyl methylsulfinylbenzimidazole 失效
    含有吡啶基甲基亚磺酰基苯并咪唑的注射溶液

    公开(公告)号：US5223515A

    公开(公告)日：1993-06-29

    申请号：US921996

    申请日：1992-08-04

    申请人： Yasushi Mikura ,  Akihiro Nagai ,  Hisayoshi Shimizu

    发明人： Yasushi Mikura ,  Akihiro Nagai ,  Hisayoshi Shimizu

    IPC分类号： A61K9/00 ,  A61K31/44 ,  A61K47/10

    CPC分类号： A61K9/0019 ,  A61K31/44 ,  A61K47/10 ,  Y10S514/925

    摘要： An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group; R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, is provided by dissolving the compound in at least one of ethanol, propylene glycol and polyethylene glycol; or by dissolving the freeze-dried material of an alkaline aqueous solution of the compound in a mixture of an acidic substance and at least one of the above solvents.

    摘要翻译： 用作下式的抗溃疡剂的化合物的可注射溶液; 其中R1代表氢，甲氧基或三氟甲基; R2和R3彼此相同或不同，表示氢或甲基; R4表示氟化C2〜C5低级烷基，是通过将化合物溶于乙醇，丙二醇和聚乙二醇中的至少一种来提供的; 或者将化合物的碱性水溶液的冷冻干燥物质溶解在酸性物质和上述溶剂中的至少一种的混合物中。

    Magnetic sensor and current measuring apparatus
    10.
    发明授权
    Magnetic sensor and current measuring apparatus 有权
    磁传感器和电流测量装置

    公开(公告)号：US08952680B2

    公开(公告)日：2015-02-10

    申请号：US13426803

    申请日：2012-03-22

    申请人： Akihiro Nagai ,  Yoshinori Furuhata ,  Satoshi Imaizumi

    发明人： Akihiro Nagai ,  Yoshinori Furuhata ,  Satoshi Imaizumi

    IPC分类号： G01R15/18 ,  G01R1/22

    CPC分类号： G01R15/186 ,  G01R1/22

    摘要： A magnetic sensor includes two sensor units with curved cores including meshing portions at front and base ends thereof and constructs a ring when the meshing portions mesh together. The meshing portions include main meshing portions that entirely overlap in a completely meshed state where the meshing portions overlap to the greatest extent. Auxiliary meshing portions that protrude inside and/or outside the ring are provided on the main meshing portions at the front and/or the base ends. In the completely meshed state, the auxiliary meshing portions do not overlap the main meshing portions or auxiliary meshing portions of the other core. In a non-completely meshed state where the main meshing portions partially do not overlap, the auxiliary meshing portions at least partially overlap the main meshing portions and/or auxiliary meshing portions of the other core.

    摘要翻译： 磁传感器包括两个具有弯曲磁芯的传感器单元，包括在其前端和底端处的啮合部分，并且当啮合部分啮合在一起时构成环。 啮合部分包括在啮合部分最大程度地重叠的完全啮合状态下完全重叠的主啮合部分。 在内侧和/或外侧突出的辅助啮合部分设置在前端和/或基端的主啮合部分上。 在完全啮合状态下，辅助啮合部分不与另一个芯的主啮合部分或辅助啮合部分重叠。 在主啮合部分不重叠的非完全啮合状态下，辅助啮合部分至少部分地与另一个芯的主啮合部分和/或辅助啮合部分重叠。