公开(公告)号：US20190194291A1

公开(公告)日：2019-06-27

申请号：US16184147

申请日：2018-11-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Peter Bruenker ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Ekkehard Moessner ,  Pablo Umana ,  Maria Amann ,  Christina Claus ,  Wei Xu

IPC: C07K14/705 ,  C07K16/40 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K14/70578 ,  A61K39/395 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/70575 ,  C07K14/7151 ,  C07K16/14 ,  C07K16/241 ,  C07K16/2803 ,  C07K16/3007 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2319/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.

公开(公告)号：US20160200833A1

公开(公告)日：2016-07-14

申请号：US15067024

申请日：2016-03-10

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Victor Levitsky ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705

CPC classification number: C07K16/40 ,  A61K39/395 ,  C07K14/70575 ,  C07K16/2803 ,  C07K16/3007 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/526 ,  C07K2317/60 ,  C07K2317/92 ,  C07K2319/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

Abstract translation: 本发明涉及新型含有TNF家族配体三聚体的抗原结合分子，其包含（a）至少一个能够与靶细胞抗原特异性结合的部分和（b）通过二硫键彼此连接的第一和第二多肽 键，其特征在于，第一多肽包含通过肽接头彼此连接的TNF配体家族成员或其片段的两个胞外域，并且第二多肽仅包含所述TNF配体家族成员的一个胞外域或其片段 。

公开(公告)号：US12202870B2

公开(公告)日：2025-01-21

申请号：US17455617

申请日：2021-11-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525 ,  A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20230123178A1

公开(公告)日：2023-04-20

申请号：US17649321

申请日：2022-01-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Claudia Ferrara Koller ,  Christina Claus ,  Christian Klein ,  Stefan Seeber ,  Maria Amann ,  Sandra Grau-Richards ,  Peter Bruenker ,  Pablo Umana ,  Viktor Levitski ,  Ekkehard Moessner

IPC: C07K16/28 ,  C07K14/705 ,  C12N15/62 ,  A61P35/00

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules having at least one moiety capable of specific binding to PD1 and a first and a second polypeptide that are linked to each other by a disulfide bond, the first polypeptide having two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and the second polypeptide having a single ectodomain of the same TNF ligand family member or a fragment thereof.

公开(公告)号：US11306154B2

公开(公告)日：2022-04-19

申请号：US16522391

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  A61K38/00 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20200247904A1

公开(公告)日：2020-08-06

申请号：US16522391

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US10526413B2

公开(公告)日：2020-01-07

申请号：US15280379

申请日：2016-09-29

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Ralf Hosse ,  Christian Klein ,  Viktor Levitski ,  Pablo Umana

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00

Abstract: The invention relates to antibody or antibody fragments thereof that bind to OX40, methods of producing these antibodies and fragments, and to methods of using the same.

公开(公告)号：US10464981B2

公开(公告)日：2019-11-05

申请号：US15087405

申请日：2016-03-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  C07K14/525 ,  C07K14/705 ,  A61K39/395 ,  A61K38/00

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20190248877A1

公开(公告)日：2019-08-15

申请号：US16186443

申请日：2018-11-09

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K16/18 ,  A61P35/00 ,  C07K14/525 ,  A61K47/65

CPC classification number: C07K16/18 ,  A61K47/65 ,  A61K47/6813 ,  A61K47/6845 ,  A61P35/00 ,  C07K14/525 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (TnC) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20190185566A1

公开(公告)日：2019-06-20

申请号：US16189041

申请日：2018-11-13

Applicant: Hoffmann-La Roche Inc.

Inventor： Claudia Ferrara Koller ,  Christina Claus ,  Christian Klein ,  Stefan Seeber ,  Maria Amann ,  Sandra Grau-Richards ,  Peter Bruenker ,  Pablo Umana ,  Viktor Levitski ,  Ekkehard Moessner

IPC: C07K16/28 ,  C07K14/705 ,  A61P35/00

CPC classification number: C07K16/2818 ,  A61P35/00 ,  C07K14/70575 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/74 ,  C07K2319/75 ,  C12N15/62

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to PD1 and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.