公开(公告)号：US20250101135A1

公开(公告)日：2025-03-27

申请号：US18739171

申请日：2024-06-10

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Regula ,  Pablo Umana

IPC: C07K16/40 ,  A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US11149083B2

公开(公告)日：2021-10-19

申请号：US16186443

申请日：2018-11-09

Applicant: Hoffmann—La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K16/18 ,  A61K47/65 ,  A61P35/00 ,  C07K14/525 ,  A61K47/68 ,  C07K14/715 ,  C07K16/24

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (TnC) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20200270321A1

公开(公告)日：2020-08-27

申请号：US16653652

申请日：2019-10-15

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525 ,  C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  C07K16/30 ,  A61K39/395

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20240352136A1

公开(公告)日：2024-10-24

申请号：US18687561

申请日：2022-09-02

Applicant: Hoffmann-La Roche Inc. ,  Genentech, Inc.

Inventor： Maria Amann ,  Laurène Pousse ,  Christophe Boetsch ,  Martin Weisser ,  Theresa Kolben ,  Vaios Karanikas ,  Jan Eckmann ,  Bruno Carneiro de Medeiros

IPC: C07K16/28 ,  A61K31/496 ,  A61K31/706 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K31/496 ,  A61K31/706 ,  A61K39/3955 ,  C07K2317/35 ,  C07K2317/40 ,  C07K2317/732

Abstract: The present invention relates to anti-CD-25 antibodies for use in the treatment of acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL).

公开(公告)号：US20240043535A1

公开(公告)日：2024-02-08

申请号：US18067330

申请日：2022-12-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Alejandro Carpy Gutierrez Cirlos ,  Christina Claus ,  Laura Codarri Deak ,  Diana Darowski ,  Tanja Fauti ,  Claudia Ferrara Koller ,  Anne Freimoser-Grundschober ,  Sylvia Herter ,  Thomas Hofer ,  Christian Klein ,  Laura Lauener ,  Stephane Leclair ,  Ekkehard Moessner ,  Christiane Neumann ,  Pablo Umaña ,  Ali Bransi ,  Marlena Surówka

IPC: C07K16/28 ,  C07K14/55 ,  C07K14/54 ,  C07K14/56 ,  C07K14/57 ,  A61P35/00

CPC classification number: C07K16/2809 ,  C07K16/2818 ,  C07K16/2878 ,  C07K14/55 ,  C07K14/5418 ,  C07K14/5443 ,  C07K14/56 ,  C07K14/57 ,  C07K14/54 ,  C07K16/283 ,  A61P35/00 ,  C07K2319/30

Abstract: The present invention generally relates to novel immune activating Fc domain binding molecules for activation of immune cells and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

公开(公告)号：US11639394B2

公开(公告)日：2023-05-02

申请号：US16581756

申请日：2019-09-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra Grau-Richards ,  Christian Klein ,  Pablo Umaña ,  Maria Amann ,  Laurene Pousse

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The invention relates to bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to epithelial cell adhesion molecule (EpCAM), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11536716B2

公开(公告)日：2022-12-27

申请号：US15745666

申请日：2016-06-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Rosmarie Albrecht ,  Maria Amann ,  Christina Claus ,  Sandra Grau-Richards ,  Joerg Zielonka

IPC: G01N33/542 ,  G01N33/68 ,  G01N33/50

Abstract: The present invention relates to a new cell based assay for combined determination of antibody or ligand binding and function in the same vial.

公开(公告)号：US12240911B2

公开(公告)日：2025-03-04

申请号：US16684258

申请日：2019-11-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Ralf Hosse ,  Christian Klein ,  Viktor Levitski ,  Pablo Umana

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11453722B2

公开(公告)日：2022-09-27

申请号：US16584931

申请日：2019-09-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Sandra Grau-Richards ,  Christian Klein ,  Mudita Pincha ,  Pablo Umaña

IPC: C07K16/28 ,  C07K16/18

Abstract: The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to tenascin C (TnC), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20220267395A1

公开(公告)日：2022-08-25

申请号：US17455617

申请日：2021-11-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525 ,  C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  C07K16/30 ,  A61K39/395

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.