公开(公告)号：US09129424B2

公开(公告)日：2015-09-08

申请号：US13864716

申请日：2013-04-17

Applicant: Hui Xue ,  Peter Kellman ,  Andreas Greiser

Inventor： Hui Xue ,  Peter Kellman ,  Andreas Greiser

IPC: G06K9/00 ,  G06T11/00 ,  G01R33/50 ,  G01R33/565

CPC classification number: G06T11/003 ,  G01R33/50 ,  G01R33/56509

Abstract: Phase sensitive T1 mapping is provided in magnetic resonance (MR). The phase from samples of a modified Look-Locker inversion recovery sequence may be used to normalize contrast, allowing for accurate motion registration without extra information acquisition. The sign may be estimated, allowing T1 mapping with a single application of a non-linear fit.

Abstract translation: 在磁共振（MR）中提供相敏T1映射。 来自改进的Look-Locker反转恢复序列的样本的相位可以用于对比度的归一化，允许精确的运动注册，而不需要额外的信息获取。 可以估计符号，允许使用非线性拟合的单个应用的T1映射。

公开(公告)号：US09053386B2

公开(公告)日：2015-06-09

申请号：US13509059

申请日：2012-01-18

Applicant: Hui Xue

Inventor： Hui Xue

IPC: G06K9/62 ,  G06F17/30

CPC classification number: G06K9/6202 ,  G06F17/30259 ,  G06K9/4604 ,  G06K9/4642 ,  G06K9/6212 ,  G06K9/6215

Abstract: A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.

Abstract translation: 用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。 服务器可以基于提交的图像的内容生成图像签名。 服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。 这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。 这些候选图像可以基于相似性被分类并输出给用户。 可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

公开(公告)号：US20130301935A1

公开(公告)日：2013-11-14

申请号：US13509059

申请日：2012-01-18

Applicant: Hui Xue

Inventor： Hui Xue

IPC: G06K9/62

CPC classification number: G06K9/6202 ,  G06F17/30259 ,  G06K9/4604 ,  G06K9/4642 ,  G06K9/6212 ,  G06K9/6215

Abstract: A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.

Abstract translation: 用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。 服务器可以基于提交的图像的内容生成图像签名。 服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。 这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。 这些候选图像可以基于相似性被分类并输出给用户。 可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

公开(公告)号：US08577177B2

公开(公告)日：2013-11-05

申请号：US13291370

申请日：2011-11-08

Applicant: Christoph Guetter ,  Christophe Chefd'hotel ,  Hui Xue ,  Jens Guehring

Inventor： Christoph Guetter ,  Christophe Chefd'hotel ,  Hui Xue ,  Jens Guehring

IPC: G06K9/32

CPC classification number: G06T3/0068 ,  G06K2209/051

Abstract: A method for symmetric and inverse-consistent registration of a pair of digital images includes calculating a first update of a forward transformation of a first digital image to a second digital image from a previous update of the forward transformation and a gradient of a cost function of the first and second digital images, calculating a first update of a backward transformation of the second digital image to the first digital image from an inverse of the first update of the forward transformation, calculating a second update of the backward transformation from first update of the backward transformation and the gradient of a cost function of the second and first digital images, and calculating a second update of the forward transformation from an inverse of the second update of the backward transformation.

Abstract translation: 用于一对数字图像的对称和反向一致配准的方法包括从前向变换的先前更新和第一数字图像的成本函数的梯度计算第一数字图像向第二数字图像的正向变换的第一更新 所述第一数字图像和所述第二数字图像从所述正向变换的所述第一更新的逆算出计算所述第二数字图像向所述第一数字图像的反向变换的第一更新，从所述正向变换的所述第一更新计算所述反向变换的第二更新， 反向变换和第二和第一数字图像的成本函数的梯度，以及从反向变换的第二更新的倒数计算正向变换的第二更新。

公开(公告)号：US20130289912A1

公开(公告)日：2013-10-31

申请号：US13779999

申请日：2013-02-28

Applicant: Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

Inventor： Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

IPC: G01R33/24

CPC classification number: G01R33/243 ,  G01R33/246 ,  G01R33/5611

Abstract: A method for estimating a coil sensitivity map for a magnetic resonance (MR) image includes providing (61) a matrix A of sliding blocks of a 2D image of coil calibration data, calculating (62) a left singular matrix V∥ from a singular value decomposition of A corresponding to τ leading singular values, calculating (63) P=V∥V∥H, calculating (64) a matrix S that is an inverse Fourier transform of a zero-padded matrix P, and solving (65) MHcr=(Sr)Hcr for cr, where cr is a vector of coil sensitivity maps for all coils at spatial location r, and M  ( ( 1 1 … 1 0 0 … 0 … … … 0 0 … 0 )  ( 0 0 … 0 1 1 … 1 … … … 0 0 … 0 )   …   ( 0 0 … 0 0 0 … 0 … … … 1 1 … 1 ) ) .

Abstract translation: 用于估计磁共振（MR）图像的线圈灵敏度映射的方法包括提供（61）线圈校准数据的2D图像的滑块的矩阵A，从奇异值计算（62）左奇异矩阵V∥ 计算（63）P = V || V | H，计算（64）作为零填充矩阵P的逆傅里叶变换的矩阵S，求解（65）MHcr = （Sr）Hcr，其中cr是空间位置r处所有线圈的线圈灵敏度图的向量，M（（1 1 ... 1 0 0 ... 0 ... ... ... 0 0 ... 0）0（0 0 ... 0 1 1 ... 1 ... ... ... 0 0 ... 0） 0 0 0 ... 0 ... ... ... 1 1 ... 1））。

公开(公告)号：US20120121154A1

公开(公告)日：2012-05-17

申请号：US13296487

申请日：2011-11-15

Applicant: Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Guhring

Inventor： Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Guhring

IPC: G06K9/00

CPC classification number: G06T7/33 ,  G06T2207/10088 ,  G06T2207/30048

Abstract: A method and system for propagation of myocardial infarction from delayed enhanced magnetic resonance imaging (DE-MRI) to cine MRI is disclosed. A reference frame is selected in a cine MRI sequence. Deformation fields are calculated within the cine MRI sequence to register the frames of the cine MRI sequence to the reference frame. A DE-MRI image having an infarction region is registered to the reference frame of the cine MRI sequence. The DE-MRI image may be registered to the infarction region using a hybrid registration algorithm that unifies both intensity and feature points into a single cost function. Infarction information in the DE-MRI image is then propagated cardiac phases of the frames in the cine MRI sequence based on the registration of the DE-MRI image to the reference frame and the plurality of deformation fields calculated within the cine MRI sequence.

Abstract translation: 公开了一种从延迟增强磁共振成像（DE-MRI）向电磁MRI传播心肌梗死的方法和系统。 在电影MRI序列中选择参考帧。 在电影MRI序列中计算变形场，以将电影MRI序列的帧注册到参考帧。 具有梗塞区域的DE-MRI图像被登记到电影MRI序列的参考帧。 可以使用将强度和特征点统一为单个成本函数的混合配准算法将DE-MRI图像登记到梗塞区域。 DE-MRI图像中的梗死信息然后基于DE-MRI图像的登记到参考帧和在电影MRI序列中计算的多个变形场，在电影MRI序列中的帧的心脏相位传播。

公开(公告)号：US09790500B2

公开(公告)日：2017-10-17

申请号：US15211857

申请日：2016-07-15

Applicant: Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

Inventor： Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7125

CPC classification number: C12N15/113 ,  A61K31/7125 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/321 ,  C12N2310/3525 ,  C12N2310/3527

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

公开(公告)号：US09279873B2

公开(公告)日：2016-03-08

申请号：US13534112

申请日：2012-06-27

Applicant: Hui Xue ,  Yu Ding

Inventor： Hui Xue ,  Yu Ding

IPC: G01V3/00 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/5611 ,  G01R33/56509

Abstract: Parallel imaging magnetic resonance reconstruction is performed with temporal sensitivity. Rather than estimate the coil sensitivity once for each coil of an array, the coil sensitivity at different times is estimated. The movement of the patient may result in different sensitivities at different times. By using the time varying sensitivity in iterative, self-consistent, non-linear parallel imaging, real-time imaging may be provided with stable artifacts in view of increasing SNR even with higher reduction factors (e.g., 4-6).

Abstract translation: 平行成像磁共振重建以时间灵敏度进行。 不是对阵列的每个线圈估计线圈灵敏度，而是估计不同时间的线圈灵敏度。 患者的运动可能导致不同时间的不同灵敏度。 通过在迭代，自相一致的非线性并行成像中使用时变灵敏度，考虑到即使具有较高的减少因子（例如，4-6）也增加了SNR，可以提供稳定的伪像。

公开(公告)号：US08649585B2

公开(公告)日：2014-02-11

申请号：US13295416

申请日：2011-11-14

Applicant: Hui Xue ,  Saurabh Shah ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff ,  Jens Guehring

Inventor： Hui Xue ,  Saurabh Shah ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff ,  Jens Guehring

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06T5/002 ,  G06T2207/10016 ,  G06T2207/10088 ,  G06T2207/20221 ,  G06T2207/30048

Abstract: A method and system for retrospective image combination for free-breathing magnetic resonance (MR) images is disclose. A free-breathing cardiac MR image acquisition including a plurality of frames is received. A key frame is selected of the plurality of frames. A deformation field for each frame to register each frame with the key frame. A weight is determined for each pixel in each frame based on the deformation field for each frame under a minimum total deformation constraint. A combination image is then generated as a weighted average of the frames using the weight determined for each pixel in each frame.

Abstract translation: 公开了用于自由呼吸磁共振（MR）图像的回顾性图像组合的方法和系统。 接收包括多个帧的自由呼吸心脏MR图像采集。 选择多个帧中的关键帧。 每个帧的变形场用关键帧来记录每个帧。 基于每个帧在最小总变形约束下的变形场，为每个帧中的每个像素确定权重。 然后，使用为每个帧中的每个像素确定的权重，生成组合图像作为帧的加权平均。

公开(公告)号：US20130278259A1

公开(公告)日：2013-10-24

申请号：US13866328

申请日：2013-04-19

Applicant: Andreas Greiser ,  Peter Schmitt ,  Hui Xue

Inventor： Andreas Greiser ,  Peter Schmitt ,  Hui Xue

IPC: G01R33/50

CPC classification number: G01R33/50 ,  G01R33/56 ,  G01R33/56509

Abstract: In a method for a rapid determination of spatially resolved magnetic resonance relaxation parameters in an area of examination, a preparation pulse is radiated into the area of examination. During the relaxation of the longitudinal magnetization, spatially encoded magnetic resonance signals are acquired at a minimum of two different points in time using a fast magnetic resonance sequence. At each inversion time, an image data record is reconstructed from the magnetic resonance signals, which are elastically registered to each other. From the recorded image data records, values of magnetic resonance relaxation parameters are spatially accurately determined.

Abstract translation: 在用于在检查区域中快速确定空间分辨的磁共振松弛参数的方法中，准备脉冲被辐射到检查区域中。 在松弛纵向磁化期间，使用快速磁共振序列在至少两个不同的时间点获取空间编码的磁共振信号。 在每个反转时间，从彼此弹性对准的磁共振信号重建图像数据记录。 从记录的图像数据记录中，磁共振松弛参数的值在空间上被精确地确定。