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    Use of Telomerase Inhibitors for the Treatment of Myeloproliferative Disorders and Myeloproliferative Neoplasms
    7.
    发明申请
    Use of Telomerase Inhibitors for the Treatment of Myeloproliferative Disorders and Myeloproliferative Neoplasms 审中-公开
    端粒酶抑制剂用于治疗骨髓增生性疾病和骨髓增生性肿瘤的应用

    公开(公告)号：US20150342982A1

    公开(公告)日：2015-12-03

    申请号：US14649125

    申请日：2013-11-15

    申请人： GERON CORPORATION

    发明人： Monic J. STUART ,  Stephen KELSEY

    IPC分类号： A61K31/7125 ,  C12N15/113

    CPC分类号： A61K31/7125 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/3145 ,  C12N2310/3515 ,  C12N2320/30 ,  C12Y207/07049

    摘要： Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have myeloproliferative disorders, such as Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having myeloproliferative disorders, such as ET.

    摘要翻译： 本文提供了用于减少肿瘤祖细胞增殖和缓解与诊断患有或被认为具有骨髓增生性疾病如基础性血小板增多症（ET）的个体相关的症状的方法。 本文还提供了使用端粒酶抑制剂在被诊断患有或怀疑具有骨髓增生性疾病如ET的个体的血液中在相对正常范围内维持血小板计数的方法。

    Antisense composition and method for treating muscle atrophy
    8.
    发明授权
    Antisense composition and method for treating muscle atrophy 有权
    反义组成和治疗肌肉萎缩的方法

    公开(公告)号：US08785410B2

    公开(公告)日：2014-07-22

    申请号：US12983798

    申请日：2011-01-03

    申请人： Patrick L. Iversen ,  Dwight D. Weller ,  Alan P. Timmins

    发明人： Patrick L. Iversen ,  Dwight D. Weller ,  Alan P. Timmins

    IPC分类号： C07H21/00

    CPC分类号： C12N15/1136 ,  A61K31/675 ,  A61K47/645 ,  C07H21/00 ,  C07K7/08 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/3145 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/30 ,  C12Q1/6876 ,  C12Q2600/158 ,  Y10T436/143333

    摘要： A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has a base sequence effective to hybridize to an expression-sensitive region of processed or preprocessed human myostatin RNA transcript, identified, in its processed form, by SEQ ID NO:6, and is capable of uptake by target muscle cells in the subject. In practicing the method, the compound is administered in an amount and at a dosage schedule to produce an overall reduction in the level of serum myostatin measured in the patient, and preferably to bring the myostatin level within the a range determined for normal, healthy individuals.

    摘要翻译： 公开了一种用于治疗人类受试者骨骼肌质量不足的方法和化合物。 该组合物是吗啉代亚基的低聚物和将一个亚基的吗啉代氮连接到相邻亚单位的5'环外碳的含磷亚基间键，含有10-40个核苷酸碱基之间，具有有效地与表达杂交的碱基序列 经处理或预处理的人肌生成抑制素RNA转录物的敏感区域，以其加工形式由SEQ ID NO：6鉴定，并且能够被摄体中的靶肌细胞摄取。 在实施该方法中，化合物以量和剂量方案施用以产生在患者体内测量的血清肌生成抑制素水平的总体降低，优选使肌生成抑制素水平在正常健康个体确定的范围内 。

    Antisense antibacterial method and compound
    9.
    发明授权
    Antisense antibacterial method and compound 有权
    反义抗菌法及化合物

    公开(公告)号：US08314072B2

    公开(公告)日：2012-11-20

    申请号：US11173847

    申请日：2005-07-01

    申请人： Bruce L. Geller ,  Jesse D. Deere ,  Patrick L. Iversen

    发明人： Bruce L. Geller ,  Jesse D. Deere ,  Patrick L. Iversen

    IPC分类号： A01N43/04 ,  C12Q1/68 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1137 ,  C07F9/65583 ,  C07F9/65613 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3145 ,  C12N2310/3233

    摘要： A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a Tm of between 50° to 60° C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases.

    摘要翻译： 公开了一种用于抑制病原菌细胞生长的方法和反义化合物。 该化合物含有不超过12个核苷酸碱基，并且具有长度不小于10个碱基的靶向核酸序列，该靶向核酸序列与在细菌的翻译起始密码子的下游方向上含有或在10个碱基内的靶序列互补 编码细菌复制必需的细菌蛋白质的mRNA。 该化合物以Tm在50℃至60℃之间的靶mRNA结合。相对较短的反义化合物比具有15个或更多碱基的靶向碱基序列的常规反义化合物显着更具活性。