公开(公告)号：US09341693B2

公开(公告)日：2016-05-17

申请号：US13413812

申请日：2012-03-07

Applicant: Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

Inventor： Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

IPC: G01R33/44 ,  G01R33/565 ,  G01R33/561 ,  G01R33/563

CPC classification number: G01R33/56509 ,  G01R33/5611 ,  G01R33/56325

Abstract: Magnetic resonance reconstruction includes motion compensation. Inverse-consistent non-rigid registration is used to determine motion between shots. The motion is incorporated into reconstruction. The incorporation compensates for the motion resulting from the period over which the MR data is acquired.

Abstract translation: 磁共振重建包括运动补偿。 反向一致的非刚性配准用于确定镜头之间的运动。 动议被纳入重建。 该并入补偿了获取MR数据的期间产生的运动。

公开(公告)号：US09279873B2

公开(公告)日：2016-03-08

申请号：US13534112

申请日：2012-06-27

Applicant: Hui Xue ,  Yu Ding

Inventor： Hui Xue ,  Yu Ding

IPC: G01V3/00 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/5611 ,  G01R33/56509

Abstract: Parallel imaging magnetic resonance reconstruction is performed with temporal sensitivity. Rather than estimate the coil sensitivity once for each coil of an array, the coil sensitivity at different times is estimated. The movement of the patient may result in different sensitivities at different times. By using the time varying sensitivity in iterative, self-consistent, non-linear parallel imaging, real-time imaging may be provided with stable artifacts in view of increasing SNR even with higher reduction factors (e.g., 4-6).

Abstract translation: 平行成像磁共振重建以时间灵敏度进行。 不是对阵列的每个线圈估计线圈灵敏度，而是估计不同时间的线圈灵敏度。 患者的运动可能导致不同时间的不同灵敏度。 通过在迭代，自相一致的非线性并行成像中使用时变灵敏度，考虑到即使具有较高的减少因子（例如，4-6）也增加了SNR，可以提供稳定的伪像。

公开(公告)号：US20120235679A1

公开(公告)日：2012-09-20

申请号：US13413812

申请日：2012-03-07

Applicant: Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

Inventor： Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

IPC: G01R33/44

CPC classification number: G01R33/56509 ,  G01R33/5611 ,  G01R33/56325

Abstract: Magnetic resonance reconstruction includes motion compensation. Inverse-consistent non-rigid registration is used to determine motion between shots. The motion is incorporated into reconstruction. The incorporation compensates for the motion resulting from the period over which the MR data is acquired.

Abstract translation: 磁共振重建包括运动补偿。 反向一致的非刚性配准用于确定镜头之间的运动。 动议被纳入重建。 该并入补偿了获取MR数据的期间产生的运动。

公开(公告)号：US20130027037A1

公开(公告)日：2013-01-31

申请号：US13534112

申请日：2012-06-27

Applicant: Hui Xue ,  Yu Ding

Inventor： Hui Xue ,  Yu Ding

IPC: G01R33/48

CPC classification number: G01R33/5611 ,  G01R33/56509

Abstract: Parallel imaging magnetic resonance reconstruction is performed with temporal sensitivity. Rather than estimate the coil sensitivity once for each coil of an array, the coil sensitivity at different times is estimated. The movement of the patient may result in different sensitivities at different times. By using the time varying sensitivity in iterative, self-consistent, non-linear parallel imaging, real-time imaging may be provided with stable artifacts in view of increasing SNR even with higher reduction factors (e.g., 4-6).

Abstract translation: 平行成像磁共振重建以时间灵敏度进行。 不是对阵列的每个线圈估计线圈灵敏度，而是估计不同时间的线圈灵敏度。 患者的运动可能导致不同时间的不同灵敏度。 通过在迭代，自相一致的非线性并行成像中使用时变灵敏度，考虑到即使具有较高的减少因子（例如，4-6）也增加了SNR，可以提供稳定的伪像。

公开(公告)号：US09547059B2

公开(公告)日：2017-01-17

申请号：US13866328

申请日：2013-04-19

Applicant: Andreas Greiser ,  Peter Schmitt ,  Hui Xue

Inventor： Andreas Greiser ,  Peter Schmitt ,  Hui Xue

IPC: G01V3/00 ,  G01R33/50 ,  G01R33/56 ,  G01R33/565

CPC classification number: G01R33/50 ,  G01R33/56 ,  G01R33/56509

Abstract: In a method for a rapid determination of spatially resolved magnetic resonance relaxation parameters in an area of examination, a preparation pulse is radiated into the area of examination. During the relaxation of the longitudinal magnetization, spatially encoded magnetic resonance signals are acquired at a minimum of two different points in time using a fast magnetic resonance sequence. At each inversion time, an image data record is reconstructed from the magnetic resonance signals, which are elastically registered to each other. From the recorded image data records, values of magnetic resonance relaxation parameters are spatially accurately determined.

Abstract translation: 在用于在检查区域中快速确定空间分辨的磁共振松弛参数的方法中，准备脉冲被辐射到检查区域中。 在松弛纵向磁化期间，使用快速磁共振序列在至少两个不同的时间点获取空间编码的磁共振信号。 在每个反转时间，从彼此弹性对准的磁共振信号重建图像数据记录。 从记录的图像数据记录中，磁共振松弛参数的值在空间上被精确地确定。

公开(公告)号：US20130272591A1

公开(公告)日：2013-10-17

申请号：US13864716

申请日：2013-04-17

Applicant: Hui Xue ,  Peter Kellman ,  Andreas Greiser

Inventor： Hui Xue ,  Peter Kellman ,  Andreas Greiser

IPC: G06T11/00

CPC classification number: G06T11/003 ,  G01R33/50 ,  G01R33/56509

Abstract: Phase sensitive T1 mapping is provided in magnetic resonance (MR). The phase from samples of a modified Look-Locker inversion recovery sequence may be used to normalize contrast, allowing for accurate motion registration without extra information acquisition. The sign may be estimated, allowing T1 mapping with a single application of a non-linear fit.

Abstract translation: 在磁共振（MR）中提供相敏T1映射。 来自改进的Look-Locker反转恢复序列的样本的相位可以用于对比度的归一化，允许精确的运动注册，而不需要额外的信息获取。 可以估计符号，允许使用非线性拟合的单个应用的T1映射。

公开(公告)号：US20170015997A1

公开(公告)日：2017-01-19

申请号：US15211857

申请日：2016-07-15

Applicant: Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

Inventor： Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

IPC: C12N15/113 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7125

CPC classification number: C12N15/113 ,  A61K31/7125 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/321 ,  C12N2310/3525 ,  C12N2310/3527

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract translation: 本文提供了调节IAP活性或治疗癌症的组合物，方法和用途。 所述组合物包含用于给予癌细胞的双靶向反义寡核苷酸（dASO），其中所述癌细胞的特征可能在于BIRC6，cIAP1或存活蛋白中的一种之一升高。 癌症可以选自以下中的一种或多种：前列腺癌; 儿童从头急性骨髓性白血病; 结肠直肠癌; 神经母细胞瘤 黑色素瘤 和非小细胞肺癌。 前列腺癌可能是去势抗性前列腺癌（CRPC）。

公开(公告)号：US08805045B2

公开(公告)日：2014-08-12

申请号：US13248309

申请日：2011-09-29

Applicant: Christoph Guetter ,  Jens Gühring ,  Marie-Pierre Jolly ,  Arne Littmann ,  Manuela Rick ,  Michaela Schmidt ,  Hui Xue

Inventor： Christoph Guetter ,  Jens Gühring ,  Marie-Pierre Jolly ,  Arne Littmann ,  Manuela Rick ,  Michaela Schmidt ,  Hui Xue

IPC: G06K9/00 ,  G06T7/00

CPC classification number: G06T7/0083 ,  G06T7/12 ,  G06T7/174 ,  G06T2207/10016 ,  G06T2207/10072 ,  G06T2207/10116 ,  G06T2207/20104 ,  G06T2207/30004

Abstract: A method for identifying a region of interest within a time sequence of images includes acquiring a time sequence of images comprising a plurality of image frames. Image segmentation is performed to segment a region of interest (ROI) from within each of the plurality of image frames of the time sequence of images. Manual edits are received for the ROI within one or more of the plurality of image frames. The manual edits are propagated to other image frames of the plurality of images. An extent to which each of the manual edits are propagated to other image frames is dependent upon a transformation function or deformation field used to propagate the manual edits and a weighing factor that is influenced by a distance in time between the other image frames and the frames that have been manually edited.

Abstract translation: 用于识别图像的时间序列内的感兴趣区域的方法包括获取包括多个图像帧的图像的时间序列。 执行图像分割以从图像的时间序列的多个图像帧的每一个内分割感兴趣区域（ROI）。 对于多个图像帧中的一个或多个中的ROI，接收手动编辑。 手动编辑被传播到多个图像的其他图像帧。 每个手动编辑传播到其他图像帧的程度取决于用于传播手动编辑的变换函数或变形字段以及受其他图像帧和帧之间的时间距离的影响的称重因子 已经被手动编辑。

公开(公告)号：US20140088899A1

公开(公告)日：2014-03-27

申请号：US14038958

申请日：2013-09-27

Applicant: Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

Inventor： Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

IPC: G01R33/24

CPC classification number: G01R33/243 ,  G01R33/246 ,  G01R33/5611

Abstract: A method for estimating a coil sensitivity map for a magnetic resonance (MR) image includes providing a matrix A of sliding blocks of a 3D image of coil calibration data, calculating a left singular matrix V∥ from a singular value decomposition of A corresponding to τ leading singular values, calculating P=V∥V∥H, calculating a matrix S that is an inverse Fourier transform of a zero-padded matrix P, and solving MHcr=(Sr)Hcr for cr, where cr is a vector of coil sensitivity maps for all coils at spatial location r, and M = ( ( 1 1 … 1 0 0 … 0 … … … 0 0 … 0 )  ( 0 0 … 0 1 1 … 1 … … … 0 0 … 0 )   …   ( 0 0 … 0 0 0 … 0 … … … 1 1 … 1 ) ) .

Abstract translation: 用于估计磁共振（MR）图像的线圈灵敏度图的方法包括提供线圈校准数据的3D图像的滑动块的矩阵A，从对应于τ的A的奇异值分解计算左奇异矩阵V∥ 计算P = V || V | H，计算作为零填充矩阵P的傅立叶逆变换的矩阵S，求解cr的MHcr =（Sr）Hcr，其中cr是线圈灵敏度的向量 对于空间位置r处的所有线圈的映射，M =（（1 1 ... 1 0 0 ... 0 ... ... 0 0 ... 0）（0 0 ... 0 1 1 ... 1 ... ... 0 0 ... 0） ...（0 0 ... 0 0 0 ... 0 ...... ... 1 1 ... 1））。

公开(公告)号：US08682054B2

公开(公告)日：2014-03-25

申请号：US13296487

申请日：2011-11-15

Applicant: Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Gühring

Inventor： Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Gühring

IPC: G06K9/00

CPC classification number: G06T7/33 ,  G06T2207/10088 ,  G06T2207/30048

Abstract: A method and system for propagation of myocardial infarction from delayed enhanced magnetic resonance imaging (DE-MRI) to cine MRI is disclosed. A reference frame is selected in a cine MRI sequence. Deformation fields are calculated within the cine MRI sequence to register the frames of the cine MRI sequence to the reference frame. A DE-MRI image having an infarction region is registered to the reference frame of the cine MRI sequence. The DE-MRI image may be registered to the infarction region using a hybrid registration algorithm that unifies both intensity and feature points into a single cost function. Infarction information in the DE-MRI image is then propagated cardiac phases of the frames in the cine MRI sequence based on the registration of the DE-MRI image to the reference frame and the plurality of deformation fields calculated within the cine MRI sequence.

Abstract translation: 公开了一种从延迟增强磁共振成像（DE-MRI）向电磁MRI传播心肌梗死的方法和系统。 在电影MRI序列中选择参考帧。 在电影MRI序列中计算变形场，以将电影MRI序列的帧注册到参考帧。 具有梗塞区域的DE-MRI图像被登记到电影MRI序列的参考帧。 可以使用将强度和特征点统一为单个成本函数的混合配准算法将DE-MRI图像登记到梗塞区域。 DE-MRI图像中的梗死信息然后基于DE-MRI图像的登记到参考帧和在电影MRI序列中计算的多个变形场，在电影MRI序列中的帧的心脏相位传播。