公开(公告)号：US20140322268A1

公开(公告)日：2014-10-30

申请号：US14222481

申请日：2014-03-21

Applicant: Infectious Disease Research Institute

Inventor： Steven G. REED ,  Darrick CARTER

IPC: A61K39/39 ,  A61K39/04 ,  C07H15/20 ,  A61K39/21 ,  A61K39/245 ,  A61K39/275 ,  C07H15/12 ,  A61K39/235

CPC classification number: A61K39/39 ,  A61K9/107 ,  A61K31/665 ,  A61K31/7016 ,  A61K39/00 ,  A61K39/04 ,  A61K39/21 ,  A61K39/235 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/525 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  C07H15/04 ,  C07H15/12 ,  C07H15/20

Abstract: Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.

Abstract translation: 提供具有以下结构（I）的化合物，特别是具有下列结构（I）的吡喃葡萄糖基脂质佐剂（GLA）化合物或其药学上可接受的盐，其中L1，L2，L3，L4，L5，L6，L7，L8，L9，L10， Y1，Y2，Y3，Y4，R1，R2，R3，R4，R5，R6如本文所定义。 还提供了用于诱导或增强免疫应答的药物组合物，疫苗组合物和相关方法。

公开(公告)号：US20180170975A1

公开(公告)日：2018-06-21

申请号：US15815512

申请日：2017-11-16

Applicant: Infectious Disease Research Institute

Inventor： Steven G. REED ,  Rhea N. COLER ,  Gregory C. IRETON ,  Sylvie BERTHOLET

IPC: C07K14/35 ,  G01N33/68 ,  A61K39/04 ,  C07K14/285

CPC classification number: C07K14/35 ,  A61K39/04 ,  A61K2039/55561 ,  C07K14/285 ,  C07K2319/00 ,  G01N33/5695 ,  G01N33/68 ,  G01N2469/20 ,  Y02A50/41 ,  Y02A50/55

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

公开(公告)号：US20180028649A1

公开(公告)日：2018-02-01

申请号：US15729512

申请日：2017-10-10

Applicant: Infectious Disease Research Institute

Inventor： Steven G. REED ,  Darrick CARTER

IPC: A61K39/39 ,  A61K9/107 ,  C07H15/04 ,  C07H15/12 ,  A61K31/665 ,  A61K39/04 ,  A61K39/00 ,  A61K39/275 ,  A61K39/245 ,  A61K39/235 ,  A61K39/21 ,  C07H15/20 ,  A61K31/7016

CPC classification number: A61K39/39 ,  A61K9/107 ,  A61K31/665 ,  A61K31/7016 ,  A61K39/00 ,  A61K39/04 ,  A61K39/21 ,  A61K39/235 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/525 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  C07H15/04 ,  C07H15/12 ,  C07H15/20

Abstract: Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1. L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1,Y2, Y3, Y4, R1, R2, R3 , R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.

公开(公告)号：US20160158329A1

公开(公告)日：2016-06-09

申请号：US14780494

申请日：2014-03-28

Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE

Inventor： Jeff GUDERIAN ,  Malcolm DUTHIE ,  Steven G. REED

IPC: A61K39/008 ,  G01N33/569

CPC classification number: A61K39/008 ,  A61K2039/55566 ,  C07K16/20 ,  C07K2319/00 ,  G01N33/56905 ,  G01N2469/20 ,  Y02A50/41

Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising one or more Leishmania antigens as well as polynucleotides encoding such polypeptides.

Abstract translation: 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含包含一种或多种利什曼原虫抗原的多肽以及编码这种多肽的多核苷酸。