公开(公告)号：US20240287142A1

公开(公告)日：2024-08-29

申请号：US18455151

申请日：2023-08-24

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Dan H. BAROUCH ,  Peter ABBINK ,  Mark Justin IAMPIETRO ,  Menzo J. E. HAVENGA

IPC分类号： C07K14/075 ,  A61K31/7088 ,  A61K35/761 ,  A61K39/235 ,  C07K14/54 ,  C12N15/861

CPC分类号： C07K14/075 ,  A61K31/7088 ,  A61K35/761 ,  A61K39/235 ,  C07K14/5425 ,  C12N15/861

摘要： Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).

公开(公告)号：US20240216501A1

公开(公告)日：2024-07-04

申请号：US18607027

申请日：2024-03-15

申请人： Gritstone bio, Inc.

发明人： Raphael Rousseau ,  Andrew Ferguson ,  Karin Jooss

IPC分类号： A61K39/235 ,  A61K9/00 ,  A61K31/4412 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C07K16/22 ,  C07K16/28 ,  C12N7/00

CPC分类号： A61K39/235 ,  A61K9/0019 ,  A61K31/4412 ,  A61K45/06 ,  A61P35/00 ,  C07K16/22 ,  C07K16/2818 ,  C07K16/2827 ,  C12N7/00 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  C12N2710/10321 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2770/36134 ,  C12N2770/36143

摘要： Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.

公开(公告)号：US20230355747A1

公开(公告)日：2023-11-09

申请号：US18246117

申请日：2021-09-23

申请人： ABLEVIA BIOTECH GMBH

发明人： Oskar SMRZKA ,  Bettina WANKO

IPC分类号： A61K39/235 ,  A61K47/64 ,  A61K47/68

CPC分类号： A61K39/235 ,  A61K47/643 ,  A61K47/644 ,  A61K47/6849 ,  A61K2039/505

摘要： A compound for the sequestration of undesirable neutralizing antibodies against viral vectors in a patient. The compound includes an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( - S - P ) (n-1) and a second peptide n-mer of the general formula P ( - S - P ) (n-1); wherein, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, independently for each of the peptide n-mers, n is an integer of at least 1, each of the peptide n-mers is bound to the biopolymer scaffold. Independently for each occurrence, P has an amino-acid sequence including a sequence fragment with a length of at least six amino acids of a capsid protein sequence of a viral vector. Compositions including the compound and sequestering and inhibiting methods are also provided.

公开(公告)号：US11702674B2

公开(公告)日：2023-07-18

申请号：US16973630

申请日：2019-06-11

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC分类号： C12N15/86 ,  A61K39/235 ,  A61P37/04 ,  A61K39/21 ,  A61K39/00 ,  A61K39/12

CPC分类号： C12N15/86 ,  A61K39/235 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61P37/04 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2740/16034 ,  C12N2740/16071

摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20230145599A1

公开(公告)日：2023-05-11

申请号：US17917873

申请日：2021-04-08

申请人： University of Pittsburgh - Of the Commonwelth System of Higher Education

发明人： Louis Falo, Jr. ,  Andrea A. Gambotto ,  Geza Erdos

IPC分类号： A61M37/00 ,  C12N15/86 ,  A61K39/235

CPC分类号： A61M37/0015 ,  C12N15/86 ,  A61K39/235 ,  A61M2037/0053 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61K2039/53

摘要： Provided herein are microneedle array devices for delivery of recombinant adenovirus particles, methods of making the devices, and used for the devices. The microneedle array devices are storage-stable at 4° C., retaining adenovirus infectivity for at least one month.

公开(公告)号：US20190201515A1

公开(公告)日：2019-07-04

申请号：US16302295

申请日：2017-05-18

申请人： OXFORD UNIVERSITY INNOVATION LIMITED

发明人： Arturo REYES-SANDOVAL

IPC分类号： A61K39/015 ,  A61K39/29 ,  A61P33/06 ,  A61K39/285 ,  A61K39/39

CPC分类号： A61K39/015 ,  A61K39/235 ,  A61K39/285 ,  A61K39/29 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61P33/06 ,  Y02A50/412

摘要： The present invention relates to particles, particularly virus-like particles (VLPs), comprising fusion polypeptides comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins (CSP) of Plasmodium vivax (Pv), together with an amino acid sequence derived from the C-terminal PvCSP sequence. In some embodiments, the fusion polypeptide additionally comprises an amino acid sequence derived from the N-terminal PvCSP sequence and/or a surface antigen polypeptide derived from Hepatitis B virus (HBV-S). The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use as vaccines for the prevention of malaria.

公开(公告)号：US20190183870A1

公开(公告)日：2019-06-20

申请号：US16066693

申请日：2017-01-04

申请人： The United States of America, as represented by Secretary, Dept. of Health and Human Services

发明人： James W. Hodge ,  Sofia R. Gameiro

IPC分类号： A61K31/4406 ,  A61K31/167 ,  A61P35/00 ,  A61K31/4166 ,  A61K31/58 ,  A61K39/00 ,  A61K39/235 ,  A61K39/275

CPC分类号： A61K31/4406 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/58 ,  A61K39/001102 ,  A61K39/001152 ,  A61K39/001182 ,  A61K39/001194 ,  A61K39/235 ,  A61K39/275 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

摘要： A method of reducing cancer cell growth, a method of increasing sensitivity of cancer cells to CTL mediated killing, and a method of increasing sensitivity of cancer cells to NK mediated killing are provided. The methods comprise treating cancer cells with a combination of a HDAC inhibitor and immunotherapy.

公开(公告)号：US20180078507A1

公开(公告)日：2018-03-22

申请号：US15706335

申请日：2017-09-15

申请人： Auburn University ,  Altimmune, Inc.

发明人： Allan E. David ,  Henry J. Baker ,  Aime K. Johnson ,  M. Scot Roberts ,  Kent R. Van Kampen ,  Prachi Sangle

IPC分类号： A61K9/50 ,  A61K9/19 ,  A61K9/00 ,  A61K39/235 ,  A61K39/145

CPC分类号： A61K9/5036 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/19 ,  A61K9/5031 ,  A61K9/5153 ,  A61K39/12 ,  A61K39/145 ,  A61K39/235 ,  A61K2039/55555 ,  A61P31/16 ,  A61P31/20 ,  C12N2710/10034 ,  C12N2710/10343 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134

摘要： Therapeutic or prophylactic compositions providing an active agent, such as an antigen or a vector that contains and expresses an antigen, encapsulated in or incorporated into a biodegradable polymeric particle are provided. The compositions can also provide an active agent that is not encapsulated in or incorporated into the biodegradable polymeric particle in order to provide an initial or prime delivery of the active agent. Particles or composites providing an active agent encapsulated by a first and second polymer are also provided, wherein polymers are distributed in a gradient from a core of the composite to a surface of the composite, and configured to provide a delayed release of the active agent by a period of 7 days to 6 months. Methods of producing composites are also provided. Pharmaceutical formulations providing a single dose composition are also provided, along with methods for administering the pharmaceutical compositions to a subject in need thereof a therapeutically effective amount of an active agent are provided.

公开(公告)号：US09744242B2

公开(公告)日：2017-08-29

申请号：US14988138

申请日：2016-01-05

申请人： Arecor Limited

发明人： Jan Jezek ,  Angela Buckler

IPC分类号： A61K47/38 ,  C07K14/005 ,  C12N7/00 ,  A61K39/235 ,  A61K47/36 ,  C12N15/86 ,  A61K47/32 ,  A61K9/00 ,  A61K47/18 ,  A61K48/00

CPC分类号： A61K47/38 ,  A61K9/0019 ,  A61K39/235 ,  A61K47/183 ,  A61K47/32 ,  A61K47/36 ,  A61K48/0008 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10351

摘要： The present invention is based on the surprising discovery that the inclusion of an anionic polymer in the adenovirus formulation enhances long-term stability of the vector composition. An aqueous formulation comprising an adenovirus vector and at least one anionic polymer is provided, together with methods of the preparation of a storage stable adenovirus aqueous formulation.

公开(公告)号：US09603912B2

公开(公告)日：2017-03-28

申请号：US13392570

申请日：2010-09-23

申请人： Timothy Farries ,  David Eckland

发明人： Timothy Farries ,  David Eckland

IPC分类号： A61K39/00 ,  A61K48/00 ,  G01N33/53 ,  G01N33/50 ,  G01N33/68 ,  A61K38/45

CPC分类号： A61K39/0011 ,  A61K31/495 ,  A61K38/45 ,  A61K39/235 ,  A61K48/005 ,  A61K48/0083 ,  A61K2039/53 ,  A61K2039/555 ,  A61K2039/577 ,  C12N7/00 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2799/022 ,  C12Y207/01021 ,  G01N33/5005 ,  G01N33/505 ,  G01N33/6854 ,  G01N2800/52 ,  A61K2300/00

摘要： An agent that stimulates antiviral immunity may be used, for the treatment of cancer. A product comprising an immunostimulant and a vector comprising a transgene that promotes death of neoplastic cells, may also be used for simultaneous, sequential or separate administration in the treatment of cancer.