公开(公告)号：US08143266B2

公开(公告)日：2012-03-27

申请号：US12595704

申请日：2008-04-11

申请人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

发明人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

IPC分类号： A61K31/437 ,  C07D221/20

CPC分类号： C07D471/20

摘要： Compounds of formula I: (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，A2，B，m，n，J，X，R4，G1，G2，G3和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或 预防CGRP涉及的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20120065190A1

公开(公告)日：2012-03-15

申请号：US12520146

申请日：2007-12-14

申请人： Ian M. Bell ,  Harold G. Selnick

发明人： Ian M. Bell ,  Harold G. Selnick

IPC分类号： A61K31/55 ,  C07D487/04 ,  A61P25/08 ,  A61P25/06 ,  A61P9/12 ,  C07D519/00 ,  A61P29/00

CPC分类号： C07D487/04 ,  A61K31/55 ,  A61K45/06 ,  C07D471/10 ,  C07D471/20 ,  C07D498/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, m, R1, R2, R3, R4 and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，m，R1，R2，R3，R4和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病， 如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08071772B2

公开(公告)日：2011-12-06

申请号：US12085131

申请日：2006-11-14

申请人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump ,  Cory R. Theberge ,  C. Blair Zartman

发明人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump ,  Cory R. Theberge ,  C. Blair Zartman

IPC分类号： C07D471/04

CPC分类号： C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2，J和K如本文所述） CGRP受体，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08003792B2

公开(公告)日：2011-08-23

申请号：US11662703

申请日：2005-09-09

申请人： Ian M. Bell ,  Cory R. Theberge ,  Craig A. Stump ,  Xufang Zhang ,  Steven N. Gallicchio ,  C. Blair Zartman

发明人： Ian M. Bell ,  Cory R. Theberge ,  Craig A. Stump ,  Xufang Zhang ,  Steven N. Gallicchio ,  C. Blair Zartman

IPC分类号： A61K31/40 ,  A61K31/438 ,  C07D401/04 ,  C07D227/02

CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D519/00 ,  Y02P20/582

摘要： The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物（其中变量A1，A2，B，J，K，m，n，R4，R5a，R5b和R5c如本文所定义）可用作CGRP受体的拮抗剂，并且可用于 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07750010B2

公开(公告)日：2010-07-06

申请号：US11662702

申请日：2005-09-09

申请人： Ian M. Bell ,  Steven N. Gallicchio ,  C. Blair Zartman ,  Cory R. Theberge ,  Xufang Zhang

发明人： Ian M. Bell ,  Steven N. Gallicchio ,  C. Blair Zartman ,  Cory R. Theberge ,  Xufang Zhang

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/519 ,  A61K31/4166 ,  A61P25/06

CPC分类号： C07D487/06 ,  C07D471/06

摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，T，U，V，W，X，Y，Z，R4，R5a，R5b ，R 5，R 6，m和n如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20100120809A1

公开(公告)日：2010-05-13

申请号：US12595704

申请日：2008-04-11

申请人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

发明人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

IPC分类号： A61K31/437 ,  C07D221/20 ,  A61P25/06

CPC分类号： C07D471/20

摘要： Compounds of formula I: (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，A2，B，m，n，J，X，R4，G1，G2，G3和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或 预防CGRP涉及的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07696192B2

公开(公告)日：2010-04-13

申请号：US11662246

申请日：2005-09-06

申请人： Ian M. Bell ,  Steven N. Gallicchio ,  Craig A. Stump ,  Cory R. Theberge ,  Joseph P. Vacca ,  C. Blair Zartman ,  Xufang Zhang

发明人： Ian M. Bell ,  Steven N. Gallicchio ,  Craig A. Stump ,  Cory R. Theberge ,  Joseph P. Vacca ,  C. Blair Zartman ,  Xufang Zhang

IPC分类号： A61K31/554

CPC分类号： C07D519/00 ,  C07D209/96 ,  C07D471/06 ,  C07D471/16 ,  C07D487/06

摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，J，K，T，U，V，W，X，Y，Z， R5a，R5b，R5c，m和n在本文中定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07625901B2

公开(公告)日：2009-12-01

申请号：US12214460

申请日：2008-06-19

申请人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

发明人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

IPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D471/04 ,  C07D519/00 ,  C07D471/20 ,  A61K31/499 ,  A61K31/4965 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/4188 ,  A61P25/06

CPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，m，n，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y如本文所述） CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20090054408A1

公开(公告)日：2009-02-26

申请号：US11660821

申请日：2005-09-06

申请人： Ian M. Bell ,  Craig A. Stump

发明人： Ian M. Bell ,  Craig A. Stump

IPC分类号： A61K31/4747 ,  C07D471/20 ,  A61K31/551 ,  A61P25/00 ,  A61P25/06

CPC分类号： C07D471/04 ,  C07D209/96 ,  C07D487/04

摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CORP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及用作CGRP受体的拮抗剂的式I化合物：其中A1（A2，B，J，K，m，n，R4，R5a，R5b和R5c如本文所定义） 治疗或预防公司涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US06358985B1

公开(公告)日：2002-03-19

申请号：US09342577

申请日：1999-06-29

申请人： Neville J. Anthony ,  Ian M. Bell ,  Douglas C. Beshore ,  Terrence M. Ciccarone ,  S. Jane de Solms ,  Christopher J. Dinsmore ,  Gerald E. Stokker

发明人： Neville J. Anthony ,  Ian M. Bell ,  Douglas C. Beshore ,  Terrence M. Ciccarone ,  S. Jane de Solms ,  Christopher J. Dinsmore ,  Gerald E. Stokker

IPC分类号： A61K314164

CPC分类号： A61K31/4174 ,  A61K31/00

摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.