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    Neural stimulator to treat sleep disordered breathing
    11.
    发明授权
    Neural stimulator to treat sleep disordered breathing 有权
    神经刺激剂治疗睡眠呼吸紊乱

    公开(公告)号：US07797050B2

    公开(公告)日：2010-09-14

    申请号：US12691392

    申请日：2010-01-21

    申请人： Imad Libbus ,  Anthony V. Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

    发明人： Imad Libbus ,  Anthony V. Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36185 ,  A61N1/3611

    摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

    摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。

    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK
    13.
    发明申请
    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 有权
    用呼吸反馈神经刺激的方法和装置

    公开(公告)号：US20120130446A1

    公开(公告)日：2012-05-24

    申请号：US13363198

    申请日：2012-01-31

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    Method and apparatus for neural stimulation with respiratory feedback
    14.
    发明授权
    Method and apparatus for neural stimulation with respiratory feedback 有权
    呼吸反馈神经刺激的方法和装置

    公开(公告)号：US08121692B2

    公开(公告)日：2012-02-21

    申请号：US11468595

    申请日：2006-08-30

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK
    15.
    发明申请
    METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 有权
    用呼吸反馈神经刺激的方法和装置

    公开(公告)号：US20080058892A1

    公开(公告)日：2008-03-06

    申请号：US11468595

    申请日：2006-08-30

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    System for neural control of respiration
    17.
    发明授权
    System for neural control of respiration 有权
    呼吸神经控制系统

    公开(公告)号：US08560072B2

    公开(公告)日：2013-10-15

    申请号：US13596595

    申请日：2012-08-28

    申请人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3601 ,  A61N1/36114

    摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

    摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。

    Method and apparatus for neural stimulation with respiratory feedback
    18.
    发明授权
    Method and apparatus for neural stimulation with respiratory feedback 有权
    呼吸反馈神经刺激的方法和装置

    公开(公告)号：US08554323B2

    公开(公告)日：2013-10-08

    申请号：US13363198

    申请日：2012-01-31

    申请人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Paul A. Haefner ,  Kristofer J. James ,  Kent Lee ,  Imad Libbus ,  Anthony V. Caparso ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36053 ,  A61B5/08 ,  A61B5/4035 ,  A61B5/4818 ,  A61N1/3601 ,  A61N1/36114

    摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.

    摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

    RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE
    19.
    发明申请
    RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
    使用可移植设备进行心脏衰竭的呼吸监测

    公开(公告)号：US20120283527A1

    公开(公告)日：2012-11-08

    申请号：US13553098

    申请日：2012-07-19

    申请人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

    发明人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

    IPC分类号： A61B5/0205 ,  A61B5/11 ,  A61B5/08

    CPC分类号： A61B5/0816 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/4818 ,  A61N1/3627 ,  A61N1/36521

    摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.

    摘要翻译： 可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。 这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。 该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。 该警报可以通过远程监视来通知病人或看护者。 睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。