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    Long acting beta-2-agonists and their use as medicaments
    11.
    发明授权
    Long acting beta-2-agonists and their use as medicaments 有权
    长效β-2-激动剂及其用作药物

    公开(公告)号：US07632834B2

    公开(公告)日：2009-12-15

    申请号：US12101462

    申请日：2008-04-11

    申请人： Thierry Bouyssou ,  Ingo Konetzki ,  Philipp Lustenberger ,  Juergen Mack ,  Andreas Schnapp ,  Dieter Wiedenmayer ,  Christoph Hoenke ,  Klaus Rudolf

    发明人： Thierry Bouyssou ,  Ingo Konetzki ,  Philipp Lustenberger ,  Juergen Mack ,  Andreas Schnapp ,  Dieter Wiedenmayer ,  Christoph Hoenke ,  Klaus Rudolf

    IPC分类号： A61K31/538 ,  A61K31/536 ,  C07D413/12 ,  C07D413/14

    CPC分类号： C07D265/36 ,  C07D413/12

    摘要： A compound of formula 1′″ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.

    摘要翻译： 式1“'的化合物，其中：V是-CH 2 - ， - NH-或-O-; R a和R b各自独立地为氢，C 1-4 - 烷基或卤素-C 1-4 - 烷基，或者R a和R b一起是C 2-5亚烷基桥，其中一个或多个氢原子任选被卤素取代; R 1和R 1'各自独立地为氢，C 1-6 - 烷基，C 3-6 - 环烷基，卤素-C 1-6 - 烷基，卤素-C 3-6环烷基或C 1-6亚烷基-C 3-6环烷基， 或者R1和R1'一起是C2-5亚烷基桥，其中一个或多个氢原子任选地被卤素取代; R 2，R 2'，R 2“和R 2”各自独立地为氢，C 1-6 - 烷基，卤素-C 1-6亚烷基，OH，HO-C 1-6 - 亚烷基，-O-C 1-6 - 烷基，C 6-10 - 芳基，C 6-10 - 芳基-C 1-4 - 亚烷基，C 6-10 - 芳基-C 1-6 - 亚烷基-O，COOH，COOC 1-6 - 烷基，O-C 1-6亚烷基 - COOH，O-C 1-6亚烷基-COOC 1-6 - 烷基，NHSO 2 -C 1-6 - 烷基，CN，NH 2，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，NO 2， C 1-6 - 烷基，SO 2 -C 1-6 - 烷基，SO-C 1-6 - 烷基，O（CO）C 1-6 - 烷基，CO C 1-6 - 烷基，NHCOC 1-6 - 烷基或卤素; 和n为0,1或2，或其光学异构体或其与药理学上可接受的酸的相应的酸加成盐，以及其作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。