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公开(公告)号：US09403894B2
公开(公告)日：2016-08-02
申请号：US13702841
申请日：2011-06-23
IPC分类号： C07K14/605 , A61K45/06 , A61K38/26
CPC分类号： C07K14/605 , A61K38/26 , A61K45/06
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain without affecting glycemic control. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the glucagon-like peptide-1 (GLP-1) receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加而不影响血糖控制的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，通过增加胰高血糖素样肽-1（GLP-1）受体的选择性，肽可以介导其作用。
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公开(公告)号：US09156901B2
公开(公告)日：2015-10-13
申请号：US13383783
申请日：2010-06-24
申请人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
发明人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605
CPC分类号： A61K38/26 , A61K47/54 , C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病和相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型酰化胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20120178670A1
公开(公告)日：2012-07-12
申请号：US13383783
申请日：2010-06-24
申请人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
发明人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
IPC分类号： A61K38/26 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/00 , A61K38/28 , A61P29/00 , A61P1/16 , A61P3/00 , A61P9/12 , C07K14/605 , A61P9/10
CPC分类号： A61K38/26 , A61K47/54 , C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病和相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型酰化胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20140011733A1
公开(公告)日：2014-01-09
申请号：US13980087
申请日：2012-01-20
申请人： Keld Fosgerau , Ditte Riber
发明人： Keld Fosgerau , Ditte Riber
IPC分类号： C07K14/605 , A61K38/26 , A61K38/28
CPC分类号： A61K38/26 , A61K38/28 , C07K14/605 , A61K2300/00
摘要： The invention relates to methods for treating metabolic disorders, including diabetes by using a combination of an acylated glucagon analogue and an insulin analogue. The invention also features a kit that includes an acylated glucagon analogue and an insuline analogue.
摘要翻译： 本发明涉及通过使用酰化胰高血糖素类似物和胰岛素类似物的组合来治疗代谢疾病，包括糖尿病的方法。 本发明还具有包含酰化胰高血糖素类似物和胰岛素类似物的试剂盒。
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公开(公告)号：US07994122B2
公开(公告)日：2011-08-09
申请号：US12664534
申请日：2008-06-16
IPC分类号： A61K38/26
CPC分类号： C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain in a subject. In particular, the invention provides novel glucagon analogue peptides effective in such methods and in the treatment of obesity, eating disorders, metabolic syndrome, and non-alcoholic liver steatosis. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防受试者体重增加的材料和方法。 特别地，本发明提供了在这些方法和治疗肥胖症，进食障碍，代谢综合征和非酒精性肝脂肪变性中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20100204105A1
公开(公告)日：2010-08-12
申请号：US12664534
申请日：2008-06-16
CPC分类号： C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain in a subject. In particular, the invention provides novel glucagon analogue peptides effective in such methods and in the treatment of obesity, eating disorders, metabolic syndrome, and non-alcoholic liver steatosis. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防受试者体重增加的材料和方法。 特别地，本发明提供了在这些方法和治疗肥胖症，进食障碍，代谢综合征和非酒精性肝脂肪变性中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US09169310B2
公开(公告)日：2015-10-27
申请号：US13704299
申请日：2011-06-24
申请人： Ditte Riber , Eddi Meier
发明人： Ditte Riber , Eddi Meier
IPC分类号： A61K38/26 , A61K45/06 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , A61K38/26 , A61K45/06
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain and for treating diabetes and associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptide compounds effective in such methods. The compounds may mediate their effect by having, for example, increased selectivity for the GLP-1 receptor compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加并用于治疗糖尿病和相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽化合物。 该化合物可以通过例如与人胰高血糖素相比增加对GLP-1受体的选择性来介导其作用。
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公开(公告)号：US20130157929A1
公开(公告)日：2013-06-20
申请号：US13704299
申请日：2011-06-24
申请人： Ditte Riber , Eddi Meier
发明人： Ditte Riber , Eddi Meier
IPC分类号： C07K14/605 , A61K45/06 , A61K38/26
CPC分类号： C07K14/605 , A61K38/00 , A61K38/26 , A61K45/06
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain and for treating diabetes and associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptide compounds effective in such methods. The compounds may mediate their effect by having, for example, increased selectivity for the GLP-1 receptor compared to human glucagon.
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