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公开(公告)号：US20050075280A1
公开(公告)日：2005-04-07
申请号：US10772774
申请日：2004-02-04
申请人： Bjarne Larsen , Jorgen Petersen , Eddi Meier , Anne Kjolbye , Niklas Jorgensen , Morten Nielsen , James Martins , Niels-Henrik Holstein-Rathlou
发明人： Bjarne Larsen , Jorgen Petersen , Eddi Meier , Anne Kjolbye , Niklas Jorgensen , Morten Nielsen , James Martins , Niels-Henrik Holstein-Rathlou
IPC分类号： A61K38/08 , A61K38/10 , A61K38/12 , C07K5/06 , C07K5/078 , C07K5/083 , C07K5/117 , C07K7/06 , C07K7/08 , C07K7/64 , C07K11/02
CPC分类号： C07K5/06165 , C07K5/06026 , C07K5/0806 , C07K5/1024 , C07K7/06 , C07K7/64 , Y10S514/821 , Y10S514/928
摘要： Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
摘要翻译： 公开了包括具有改善的稳定性的抗心律不齐肽的新型肽。 进一步公开的是包括这些肽的组合物以及将组合物特别用作药物的方法。
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公开(公告)号：US08642541B2
公开(公告)日：2014-02-04
申请号：US13139678
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US08642540B2
公开(公告)日：2014-02-04
申请号：US13139482
申请日：2008-12-15
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供了用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20130157935A1
公开(公告)日：2013-06-20
申请号：US13702841
申请日：2011-06-23
IPC分类号： C07K14/605 , A61K45/06 , A61K38/26
CPC分类号： C07K14/605 , A61K38/26 , A61K45/06
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain without affecting glycemic control. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加而不影响血糖控制的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US07994122B2
公开(公告)日：2011-08-09
申请号：US12664534
申请日：2008-06-16
IPC分类号： A61K38/26
CPC分类号： C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain in a subject. In particular, the invention provides novel glucagon analogue peptides effective in such methods and in the treatment of obesity, eating disorders, metabolic syndrome, and non-alcoholic liver steatosis. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防受试者体重增加的材料和方法。 特别地，本发明提供了在这些方法和治疗肥胖症，进食障碍，代谢综合征和非酒精性肝脂肪变性中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20110293587A1
公开(公告)日：2011-12-01
申请号：US13139678
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N5/10 , C12N1/15 , A61K31/7088 , A61K48/00 , A61K35/74 , A61K35/68 , A61K36/06 , A61K35/64 , A61K35/12 , A61K36/064 , A61K36/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/04 , A61P9/00 , A61P3/06 , A61P29/00 , A61P1/16 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病，代谢综合征和相关疾病的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US20110286982A1
公开(公告)日：2011-11-24
申请号：US13139493
申请日：2008-12-15
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N1/15 , C12N5/10 , A61K48/00 , A61K31/7088 , A61P3/04 , A61P3/00 , A61P29/00 , A61P1/16 , A61P25/00 , A61P3/08 , A61P3/10 , A61P9/12 , A61P3/06 , A61P9/10 , A61P9/00 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US20110286981A1
公开(公告)日：2011-11-24
申请号：US13139487
申请日：2008-12-15
申请人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
发明人： Eddi Meier , Ditte Riber , Marie Skovgaard , Bjarne Due Larsen , Jens Rosengren Daugaard , Trine Skovlund Ryge Neerup
IPC分类号： A61K38/26 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N1/11 , C12N5/10 , C12N1/15 , A61K31/7088 , A61K48/00 , A61K35/74 , A61K35/68 , A61K36/06 , A61K35/64 , A61K35/12 , A61K36/064 , A61K36/00 , A61P9/10 , A61P3/10 , A61P9/12 , A61P3/04 , A61P9/00 , A61P3/06 , A61P29/00 , A61P1/16 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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公开(公告)号：US20100204105A1
公开(公告)日：2010-08-12
申请号：US12664534
申请日：2008-06-16
CPC分类号： C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain in a subject. In particular, the invention provides novel glucagon analogue peptides effective in such methods and in the treatment of obesity, eating disorders, metabolic syndrome, and non-alcoholic liver steatosis. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防受试者体重增加的材料和方法。 特别地，本发明提供了在这些方法和治疗肥胖症，进食障碍，代谢综合征和非酒精性肝脂肪变性中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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公开(公告)号：US09156901B2
公开(公告)日：2015-10-13
申请号：US13383783
申请日：2010-06-24
申请人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
发明人： Ditte Riber , Eddi Meier , Jens Rosengren Daugaard , Marie Skovgaard , Jakob Lind Tolborg , Gita Kampen , Camilla Ærteberg Bæk
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605
CPC分类号： A61K38/26 , A61K47/54 , C07K14/605
摘要： The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供用于促进体重减轻或预防体重增加以及治疗糖尿病和相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型酰化胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性而介导其作用。
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