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公开(公告)号：US20050288354A1
公开(公告)日：2005-12-29
申请号：US10937791
申请日：2004-09-08
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , A61K31/404
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号：US20050038246A1
公开(公告)日：2005-02-17
申请号：US10893134
申请日：2004-07-16
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D471/02 , C07D487/02
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US20080096913A1
公开(公告)日：2008-04-24
申请号：US12001026
申请日：2007-12-07
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/44 , A61K31/40 , A61K31/47 , A61P3/04 , A61K31/405
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US20070149603A1
公开(公告)日：2007-06-28
申请号：US11679777
申请日：2007-02-27
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D209/18 , A61K31/405
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US20080045581A1
公开(公告)日：2008-02-21
申请号：US11679792
申请日：2007-02-27
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/404 , A61P3/00 , A61P35/00 , A61P9/00 , C07D209/18 , C07D409/12
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US07723374B2
公开(公告)日：2010-05-25
申请号：US11679738
申请日：2007-02-27
申请人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
发明人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US07476746B2
公开(公告)日：2009-01-13
申请号：US11679792
申请日：2007-02-27
申请人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
发明人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
IPC分类号： A61K31/40 , A61K31/41 , A61K31/405
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号：US07531568B2
公开(公告)日：2009-05-12
申请号：US11289656
申请日：2005-11-29
申请人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
发明人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
IPC分类号： A61K31/405 , C07D403/02
CPC分类号： C07D209/36 , C07D209/30 , C07D209/40
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ的至少一种的治疗和/或预防方法。
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公开(公告)号：US07491831B2
公开(公告)日：2009-02-17
申请号：US11679777
申请日：2007-02-27
申请人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
发明人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
IPC分类号： A61K31/40 , A61K31/41 , A61K31/405
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US20080234349A1
公开(公告)日：2008-09-25
申请号：US11517010
申请日：2006-09-06
申请人： Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
发明人： Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
IPC分类号： A61K31/4155 , C07D409/12 , A61K31/4025 , A61P25/00 , A61P3/04 , C07D409/14
CPC分类号： C07D409/12 , C07D209/08 , C07D409/14
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
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