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公开(公告)号:US08053463B2
公开(公告)日:2011-11-08
申请号:US12043069
申请日:2008-03-05
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: C07D209/04 , C07D401/02 , A61K31/454 , A61K31/404
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ中的至少一种的治疗和/或预防方法,其中所述化合物具有下式:其中 :X2和X3独立地是CH或N; X1和X4之一是N或CR4,X1和X4中的另一个是N或CH。
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公开(公告)号:US20080249137A1
公开(公告)日:2008-10-09
申请号:US11517572
申请日:2006-09-06
申请人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/44 , C07C235/34 , A61K31/165 , A61K31/192 , A61P3/04 , C07C57/58 , C07D213/64
CPC分类号: C07C317/46 , B82Y15/00 , C07C51/08 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C61/39 , C07C69/734 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D213/64 , C07D231/12 , C07D231/24 , C07D239/54 , C07D261/08 , C07D263/32 , C07D263/46 , C07D277/24 , C07D277/36 , C07D333/32 , C07D333/34 , G01N33/588 , G01N33/6872 , C07C59/52
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ的至少一种的治疗和/或预防方法。
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公开(公告)号:US20120015966A1
公开(公告)日:2012-01-19
申请号:US13243703
申请日:2011-09-23
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/506 , C07D401/12 , C07D403/12 , A61K31/405 , A61K31/4439 , A61K31/4155 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/08 , A61P25/00 , A61P13/12 , A61P27/02 , A61P17/02 , A61P13/10 , A61P1/00 , A61P27/12 , A61P9/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P43/00 , A61P17/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P15/00 , A61P1/18 , A61P1/16 , A61P25/28 , A61P17/06 , A61P25/16 , A61P7/02 , A61P1/04 , A61P13/00 , A61P31/18 , A61P31/14 , A61P31/04 , A61P25/04 , A61P35/00 , C07D209/18
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ中的至少一种的治疗和/或预防方法。
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公开(公告)号:US07531568B2
公开(公告)日:2009-05-12
申请号:US11289656
申请日:2005-11-29
申请人: Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
发明人: Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
IPC分类号: A61K31/405 , C07D403/02
CPC分类号: C07D209/36 , C07D209/30 , C07D209/40
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ的至少一种的治疗和/或预防方法。
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公开(公告)号:US20080255201A1
公开(公告)日:2008-10-16
申请号:US12043069
申请日:2008-03-05
申请人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人: Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号: A61K31/454 , A61K31/404 , C07D209/04 , A61P3/04 , C07D401/02
CPC分类号: C07D401/12 , C07D209/18 , C07D403/12
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
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公开(公告)号:US20080234349A1
公开(公告)日:2008-09-25
申请号:US11517010
申请日:2006-09-06
申请人: Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
发明人: Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
IPC分类号: A61K31/4155 , C07D409/12 , A61K31/4025 , A61P25/00 , A61P3/04 , C07D409/14
CPC分类号: C07D409/12 , C07D209/08 , C07D409/14
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
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公开(公告)号:US20080221127A1
公开(公告)日:2008-09-11
申请号:US12043095
申请日:2008-03-05
申请人: Jack Lin , Patrick Womack , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang
发明人: Jack Lin , Patrick Womack , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang
IPC分类号: A61K31/50 , C07C63/00 , A61K31/19 , C07D231/12 , A61K31/415 , A61P3/04 , A61K31/44 , C07D211/86 , C07D239/02
CPC分类号: C07C317/46 , C07C59/68 , C07C317/44 , C07D213/64 , C07D231/12 , C07D239/34
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译: 描述了对PPARα,PPARδ和PPARγ中的至少一种具有活性的化合物,其可用于涉及调节PPARα,PPARδ和PPARγ的至少一种的治疗和/或预防方法。
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公开(公告)号:US20060116416A1
公开(公告)日:2006-06-01
申请号:US11289656
申请日:2005-11-29
申请人: Jack Lin , Dean Artis , Prabha Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
发明人: Jack Lin , Dean Artis , Prabha Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
IPC分类号: A61K31/405 , C07D403/02
CPC分类号: C07D209/36 , C07D209/30 , C07D209/40
摘要: Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
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公开(公告)号:US20070072904A1
公开(公告)日:2007-03-29
申请号:US11517573
申请日:2006-09-06
申请人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
发明人: Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean Artis , Prabha Ibrahim , Weiru Wang
IPC分类号: A61K31/4709 , A61K31/404 , C07D409/02
CPC分类号: C07D409/14 , C07D209/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPARα, PPARα and PPARδ. Also described are methods of use of the compounds in treating various diseases.
摘要翻译: 描述了对PPARs有活性的化合物,包括对于PPARα,PPARα和PPARδ的任何一种或任何两种选择性的泛活性化合物和化合物。 还描述了使用这些化合物治疗各种疾病的方法。
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公开(公告)号:US07723374B2
公开(公告)日:2010-05-25
申请号:US11679738
申请日:2007-02-27
申请人: Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
发明人: Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
IPC分类号: A61K31/405 , C07D209/12
CPC分类号: C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译: 描述了对PPARs有活性的化合物,包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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