专利检索 ap:("Jack Lin" OR "Dean R. Artis" OR "Prabha N. Ibrahim" OR "Chao Zhang" OR "Rebecca Zuckerman" OR "Ryan Bremer" OR "Shenghua Shi" OR "Byunghun Lee") AND inv:"Ryan Bremer" 第 1 页

1.

发明授权
PPAR active compounds 失效
标题翻译： PPAR活性化合物

公开(公告)号：US07531568B2

公开(公告)日：2009-05-12

申请号：US11289656

申请日：2005-11-29

申请人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee

发明人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee

IPC分类号： A61K31/405 , C07D403/02

CPC分类号： C07D209/36 , C07D209/30 , C07D209/40

摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ的至少一种的治疗和/或预防方法。

2.

发明授权
PDE4B inhibitors 有权
标题翻译： PDE4B抑制剂

公开(公告)号：US07605168B2

公开(公告)日：2009-10-20

申请号：US11219635

申请日：2005-09-02

申请人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman

发明人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman

IPC分类号： A61K31/437 , A61K31/403 , C07D471/02 , C07D405/02

CPC分类号： C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706

摘要： Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.

摘要翻译： 描述了在PDE4上有活性的化合物。还描述了使用X射线晶体学测定的PDE4B的晶体结构，使用PDE4B晶体和用于鉴定分子支架的结构信息，用于开发结合和调节PDE4B的配体，以及基于已知配体鉴定改进的配体。

3.

发明授权
Compounds and methods for kinase modulation, and indications therefor 有权

公开(公告)号：US08415469B2

公开(公告)日：2013-04-09

申请号：US12616079

申请日：2009-11-10

申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

IPC分类号： C07D413/14 , C07D401/14 , C07D471/04 , C07F7/02

CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08

摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

4.

发明申请
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症

公开(公告)号：US20120053177A1

公开(公告)日：2012-03-01

申请号：US13243748

申请日：2011-09-23

申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

IPC分类号： A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437

CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08

摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

摘要翻译： 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

5.

发明申请
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 有权

公开(公告)号：US20100256365A1

公开(公告)日：2010-10-07

申请号：US12616079

申请日：2009-11-10

申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi

IPC分类号： C07D413/14 , C07D401/14 , C07F7/02 , C07D471/04

CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08

摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

6.

发明申请
PPAR active compounds 失效

公开(公告)号：US20060116416A1

公开(公告)日：2006-06-01

申请号：US11289656

申请日：2005-11-29

申请人： Jack Lin , Dean Artis , Prabha Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee

发明人： Jack Lin , Dean Artis , Prabha Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee

IPC分类号： A61K31/405 , C07D403/02

CPC分类号： C07D209/36 , C07D209/30 , C07D209/40

摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

7.

发明授权
Compounds and methods for kinase modulation, and indications therefor 有权
标题翻译：用于激酶调节的化合物和方法及其适应症

公开(公告)号：US08470818B2

公开(公告)日：2013-06-25

申请号：US12906980

申请日：2010-10-18

申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi

发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , Jianming Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi

IPC分类号： A61K31/535

CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08

摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

摘要翻译： 描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

8.

发明授权
Compounds and methods for kinase modulation, and indications therefor 有权

公开(公告)号：US07863288B2

公开(公告)日：2011-01-04

申请号：US11473347

申请日：2006-06-21

申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi

发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Shumeye Mamo , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Shenghua Shi

IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44

CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08

摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

9.

发明申请
COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR 审中-公开
标题翻译：化合物调节C-CIT和C-FMS活性及其用途

公开(公告)号：US20110166174A1

公开(公告)日：2011-07-07

申请号：US12958376

申请日：2010-12-01

申请人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu

发明人： Chao Zhang , Jiazhong Zhang , Prabha N. Ibrahim , Clarence R. Hurt , Rebecca Zuckerman , Dean R. Artis , Ryan Bremer , Wayne Spevak , Guoxian Wu , Hongyao Zhu

IPC分类号： A61K31/437 , A61P37/08 , A61P11/06 , A61P19/02 , A61P25/00 , A61P41/00 , A61P3/10 , A61P1/00 , A61P27/02

CPC分类号： C07D471/04

摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.

摘要翻译： 本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。