公开(公告)号：US08090432B2

公开(公告)日：2012-01-03

申请号：US12039294

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B6/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, an isobestic blood volume index in response to determined light measurements of the plurality of light measurements from a first light source of the plurality of light sources emitting light at an isobestic wavelength, determines an oxygen index associated with light measurements of the plurality of light measurements from a light source of the plurality of light sources other than the first light source, and verifies the identifying of the cardiac event in response to the determined isobestic blood volume index and the determined oxygen index.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于来自多个光源中的多个光源的确定的光测量而测量的异常血液体积指数 异常波长，确定与来自除了第一光源之外的多个光源的光源的多个光测量的光测量相关联的氧指数，并且响应于所确定的异源血液来验证心脏事件的识别 体积指数和确定的氧指数。

公开(公告)号：US20100318149A1

公开(公告)日：2010-12-16

申请号：US12797793

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.

摘要翻译： 一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出 信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激;以及处理器，其耦合到心脏电极和监测 模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态 响应于检测到的tis的速率中的至少一种的心律失常 检测氧合反应的下降和组织氧合恢复率。

公开(公告)号：US20080208269A1

公开(公告)日：2008-08-28

申请号：US12039326

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61N1/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device system for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, determines changes in perfusion in response to first changes in the plurality of light measurements in a direction indicative of a decrease in blood oxygenation and second changes in a direction indicative of a decrease in blood volume, and adjusts delivery of therapy by the device in response to the determined loss of perfusion.

摘要翻译： 一种用于感测心脏事件的医疗装置系统，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源和检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于多个光测量中指示血氧饱和度降低的方向和方向上的第二变化的方向响应于第一变化来确定灌注变化 指示血容量的减少，并且响应于确定的灌注损失来调整装置的治疗递送。

公开(公告)号：US20080208066A1

公开(公告)日：2008-08-28

申请号：US12039242

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B5/02

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor generates an ambient light measurement in response to ambient light detected by the detector, generates a plurality of light measurements in response to the emitted light detected by the detector, and adjusts the plurality of light measurements in response to the ambient light measurement.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的环境光产生环境光测量，响应于由检测器检测到的发射光产生多个光测量，并且响应于环境光测量来调整多个光测量。

公开(公告)号：US08391979B2

公开(公告)日：2013-03-05

申请号：US12797793

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.

摘要翻译： 一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出 信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激;以及处理器，其耦合到心脏电极和监测 模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态 响应于检测到的tis的速率中的至少一种的心律失常 检测氧合反应的下降和组织氧合恢复率。

公开(公告)号：US08320984B2

公开(公告)日：2012-11-27

申请号：US12765345

申请日：2010-04-22

申请人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

IPC分类号： A61B5/00

CPC分类号： A61N1/3702 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6846 ,  A61N1/36557 ,  Y10T29/49002

摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The size of at least one of emit and receive module lenses of an optical sensor, and the offset between the opto-electronic component and the respective lens of at least one of emit and receive modules is decreased to increase amplitude of the signal received by the receive module from the emit module.

摘要翻译： 用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。 光传感器的发射和接收模块透镜中的至少一个的尺寸以及光电元件与发射模块和接收模块中的至少一个的相应透镜之间的偏移被减小以增加由 从发射模块接收模块。

公开(公告)号：US08165662B2

公开(公告)日：2012-04-24

申请号：US12039281

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B6/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量，并且响应于以异常波长发射光的多个光源的光源产生血液体积指数。 然后利用血容量指数来验证心脏事件的识别。

公开(公告)号：US20110190608A1

公开(公告)日：2011-08-04

申请号：US12765345

申请日：2010-04-22

申请人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

IPC分类号： A61B5/1455 ,  A61B5/00 ,  H05K13/00

CPC分类号： A61N1/3702 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6846 ,  A61N1/36557 ,  Y10T29/49002

摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The size of at least one of emit and receive module lenses of an optical sensor, and the offset between the opto-electronic component and the respective lens of at least one of emit and receive modules is decreased to increase amplitude of the signal received by the receive module from the emit module.

摘要翻译： 用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。 光传感器的发射和接收模块透镜中的至少一个的尺寸以及光电元件与发射模块和接收模块中的至少一个的相应透镜之间的偏移被减小以增加由 从发射模块接收模块。

公开(公告)号：US20100317947A1

公开(公告)日：2010-12-16

申请号：US12797823

申请日：2010-06-10

申请人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

发明人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557

摘要： A medical device system and associated method control the delivery of a therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the therapy is adjusted in response to detecting the decreased tissue oxygenation.

摘要翻译： 医疗装置系统和相关联的方法控制对患者的治疗的递送。 该系统包括活动传感器并检测患者的活动水平的变化。 该系统还包括用于感测对应于组织光衰减的信号的光学传感器。 响应于检测到活动水平的变化，系统计算组织氧合测量。 响应于检测到组织氧合减少而调整治疗递送的参数。

公开(公告)号：US20100317946A1

公开(公告)日：2010-12-16

申请号：US12797781

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61B5/145 ,  A61B5/0402

CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.

摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。