公开(公告)号：US20110223183A1

公开(公告)日：2011-09-15

申请号：US13060254

申请日：2009-08-21

Applicant: Jan Kitajewski ,  Carrie Shawber

Inventor： Jan Kitajewski ,  Carrie Shawber

IPC: A61K39/395 ,  C07K19/00 ,  A61P35/00 ,  A61P35/04 ,  A61P3/00

CPC classification number: C07K14/485 ,  A61K38/177 ,  A61K38/179 ,  A61K38/1793 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K16/46 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30

Abstract: This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.

Abstract translation: 本发明提供了融合蛋白，其包含信号肽EGF重复人Notch3受体蛋白的细胞外结构域的1-X，其中X为12至34的任何整数，以及与其结合的抗体的Fc部分。 本发明还提供了治疗患有肿瘤的受试者的方法，用于抑制受试者血管发生的方法，用于治疗患有卵巢癌的受试者的方法，以及用于治疗具有代谢紊乱的受试者的方法，所述方法包括对所述受试者施用 上述融合蛋白有效治疗受试者的量。 本发明还提供了上述融合蛋白用于制备用于治疗患有肿瘤的受试者，用于抑制受试者的血管生成，用于治疗患有卵巢癌的受试者的药物组合物的用途，以及用于治疗具有代谢 紊乱。

公开(公告)号：US20180303901A1

公开(公告)日：2018-10-25

申请号：US15976534

申请日：2018-05-10

Applicant: Utpal Pajvani ,  Jan Kitajewski

Inventor： Utpal Pajvani ,  Jan Kitajewski

IPC: A61K38/17 ,  C07K14/705 ,  A61K45/06 ,  A61K48/00

CPC classification number: A61K38/177 ,  A61K45/06 ,  A61K48/00 ,  C07K14/705 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present invention provides a method of treating a subject suffering from a fatty liver disease which comprises administering to the subject a Notch decoy protein or Jagged inhibitor in an amount effective to treat the subject's fatty liver disease.The present invention provides a composition comprising a pharmaceutically acceptable carrier and an amount of a Notch decoy protein or Jagged inhibitor effective to treat a fatty liver disease.The present invention provides a package comprising: (a) the pharmaceutical composition of the invention; and (b) instructions for using the pharmaceutical composition of step (a) to treat the fatty liver disease.

公开(公告)号：US20160030513A1

公开(公告)日：2016-02-04

申请号：US14814407

申请日：2015-07-30

Applicant: Utpal Pajvani ,  Jan Kitajewski

Inventor： Utpal Pajvani ,  Jan Kitajewski

IPC: A61K38/17 ,  A61K45/06

CPC classification number: A61K38/177 ,  A61K45/06 ,  A61K48/00 ,  C07K14/705 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present invention provides a method of treating a subject suffering from a fatty liver disease which comprises administering to the subject a Notch decoy protein or Jagged inhibitor in an amount effective to treat the subject's fatty liver disease.The present invention provides a composition comprising a pharmaceutically acceptable carrier and an amount of a Notch decoy protein or Jagged inhibitor effective to treat a fatty liver disease.The present invention provides a package comprising:(a) the pharmaceutical composition of the invention and (b) instructions for using the pharmaceutical composition of step (a) to treat the fatty liver disease.

Abstract translation: 本发明提供了治疗患有脂肪肝疾病的受试者的方法，其包括以有效治疗受试者的脂肪肝疾病的量向受试者施用Notch诱饵蛋白或锯齿状抑制剂。 本发明提供了包含药学上可接受的载体和一定量的有效治疗脂肪肝疾病的Notch诱饵蛋白或锯齿状抑制剂的组合物。 本发明提供一种包装，其包含：（a）本发明的药物组合物和（b）使用步骤（a）的药物组合物治疗脂肪肝疾病的说明书。

公开(公告)号：US06379925B1

公开(公告)日：2002-04-30

申请号：US09467997

申请日：1999-12-20

Applicant: Jan Kitajewski ,  Hendrik Uyttendaele

Inventor： Jan Kitajewski ,  Hendrik Uyttendaele

IPC: C12P2102

CPC classification number: G01N33/5011 ,  A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  G01N33/5008 ,  G01N33/5026 ,  G01N33/5064 ,  G01N33/68 ,  G01N2333/705

Abstract: This invention provides methods of modulating angiogenesis, including promoting or inhibiting angiogenesis, e.g., in connection with treating abnormalities including hemangiomas, hemangiosarcomas, Kaposi's Sarcoma, ischemic disorders, and wounds. These methods involve administration of compounds that are selective agonists or antagonists of Notch4 protein. In addition, this invention provides an isolated nucleic acid molecule encoding a Notch4, an isolated Notch4 protein, vectors comprising an isolated nucleic acid molecule encoding a Notch4 protein, cells comprising such vectors, antibodies directed to Notch4 protein, nucleic acid probes useful for detecting nucleic acids encoding Notch4 protein, and antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes Notch4 protein.

Abstract translation: 本发明提供调节血管生成的方法，包括促进或抑制血管生成，例如与治疗异常，包括血管瘤，血管肉瘤，卡波西肉瘤，缺血性疾病和伤口有关。 这些方法涉及施用作为Notch4蛋白质的选择性激动剂或拮抗剂的化合物。 此外，本发明提供了编码Notch4，分离的Notch4蛋白的分离的核酸分子，包含编码Notch4蛋白的分离的核酸分子的载体，包含此类载体的细胞，针对Notch4蛋白的抗体，用于检测核酸的核酸探针 编码Notch4蛋白的酸和与编码Notch4蛋白的核酸分子的任何独特序列互补的反义寡核苷酸。