公开(公告)号：US06320061B1

公开(公告)日：2001-11-20

申请号：US09587752

申请日：2000-06-05

申请人： Nick Allen Collins ,  Steven Thomas Perri

发明人： Nick Allen Collins ,  Steven Thomas Perri

IPC分类号： C07D30762

CPC分类号： C07D307/62

摘要： A process for recovering an organic acid or a metal salt thereof includes contacting an alcoholic phase containing one or more organic acid(s) or metal salt(s) thereof with water under conditions effective to provide an aqueous phase containing a portion of the organic acid(s) or metal salt(s) thereof. The aqueous phase does not contain substantial amounts of the alcohol(s). This process can also include recovery of the organic acid(s) or metal salt(s) thereof from the aqueous phase.

摘要翻译： 回收有机酸或其金属盐的方法包括在有效提供含有一部分有机酸的水相的条件下使含有一种或多种有机酸或其金属盐的醇相与水接触 或其金属盐。 水相不含大量的醇。 该方法还可以包括从水相中回收有机酸或其金属盐。

公开(公告)号：US5663422A

公开(公告)日：1997-09-02

申请号：US609698

申请日：1996-03-01

申请人： Steven Thomas Perri ,  Stephen Neal Falling

发明人： Steven Thomas Perri ,  Stephen Neal Falling

IPC分类号： B01J31/16 ,  C07B61/00 ,  C07C67/26 ,  C07C69/16 ,  C07C69/28

CPC分类号： C07C67/26 ,  Y02P20/582

摘要： A process for the preparation of a 1,2-diacetoxy ester comprises acetylation of an epoxide with an acetic anhydride in the presence of a quaternary phosphonium acetate catalyst or its complex with acetic acid.

摘要翻译： 1,2-二乙酰氧基酯的制备方法包括在乙酸季鏻催化剂或其与​​乙酸的络合物存在下，用乙酸酐乙酰化环氧化物。

公开(公告)号：US06864376B2

公开(公告)日：2005-03-08

申请号：US10036912

申请日：2001-12-21

申请人： Steven Thomas Perri ,  Michael Roy Cushman ,  Jeffery Earl Grant Powell ,  Brendan William Boyd ,  Bhaskar Krishna Arumugam ,  Nick Allen Collins

发明人： Steven Thomas Perri ,  Michael Roy Cushman ,  Jeffery Earl Grant Powell ,  Brendan William Boyd ,  Bhaskar Krishna Arumugam ,  Nick Allen Collins

IPC分类号： C07B61/00 ,  C07D307/62

CPC分类号： C07D307/62 ,  Y02P20/582

摘要： The present invention comprises the use of sulfite additives to reduce discoloration of L-ascorbic acid produced from acid or aqueous solutions of 2-keto-L-gulonic acid. In one aspect, the present invention comprises a continuous process for producing L-ascorbic acid from an aqueous solution of 2-keto-L-gulonic acid. The use of sulfite additives reduces product stream color and improves product recovery by binding to high molecular weight reaction by-products. In a continuous process, the reaction stream is separated from residual sulfite and sulfite-bound by-products to produce a product stream enriched in aqueous ascorbic acid for recovery, and an enriched 2-keto-L-gulonic acid stream which is recycled to the reactor. The in situ use of sulfite additives during the reaction increases the overall yield of L-ascorbic acid, with no loss in selectivity of the synthesis.

摘要翻译： 本发明包括使用亚硫酸盐添加剂来减少由2-酮-L-古洛糖酸的酸或水溶液产生的L-抗坏血酸的变色。 一方面，本发明包括从2-酮-L-古洛糖酸的水溶液中生产L-抗坏血酸的连续方法。 使用亚硫酸盐添加剂可降低产品流颜色，并通过与高分子量反应副产物结合而提高产品回收率。 在连续方法中，将反应物流与残余的亚硫酸盐和亚硫酸盐结合的副产物分离以产生富含水溶性抗坏血酸以回收的产物流，以及富含2-酮-L-古洛糖酸流，将其再循环至 反应堆。 反应中亚硫酸盐添加剂的原位使用增加了L-抗坏血酸的总产率，合成的选择性没有损失。

公开(公告)号：US06670505B1

公开(公告)日：2003-12-30

申请号：US09519936

申请日：2000-03-07

申请人： Nick Allen Collins ,  Mark Robert Shelton ,  George William Tindall ,  Steven Thomas Perri ,  Ruairi Seosamh O'Meadhra ,  Chester Wayne Sink ,  Bhaskar Krishna Arumugam ,  John Clark Hubbs

发明人： Nick Allen Collins ,  Mark Robert Shelton ,  George William Tindall ,  Steven Thomas Perri ,  Ruairi Seosamh O'Meadhra ,  Chester Wayne Sink ,  Bhaskar Krishna Arumugam ,  John Clark Hubbs

IPC分类号： C07C5142

CPC分类号： C07C51/43 ,  Y02P20/582 ,  Y10S435/803 ,  Y10S435/876 ,  Y10S435/896 ,  C07C59/347

摘要： A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s). Specific examples of suitable organic acids include, but are not limited to, ascorbic, succinic, tartaric, glyconic, gulonic, citric, lactic, hialic, maleic, acetic, formic, gluconic pyruvic, propionic, butyric, itaconic acids and mixtures thereof. One embodiment of the present invention relates to the recovery of 2-keto-L-gulonic acid (KLG) from aqueous solutions such as fermentation baths.

摘要翻译： 从溶液中回收所需有机酸的方法包括以下步骤：提供包含至少一种所需有机酸或其酸阴离子的水溶液; 将所述水溶液中的质子浓度调节到所需的水平，其中所需质子浓度至少部分地被选择与需要回收的所需有机酸的酸性阴离子缔合所需的可用质子的量 和/或弱于所需有机酸的酸性阴离子; 以及从所述水相中回收所述至少一种所需有机酸的至少一部分。 期望的质子浓度可以基于可用质子的量大于，小于或基本上等于与所需有机酸的阴离子和酸阴离子相比所需的质子的量，其弱于 合适的有机酸的具体实例包括但不限于抗坏血酸，琥珀酸，酒石酸，葡萄糖酸，古洛糖酸，柠檬酸，乳酸，唾液酸，马来酸，乙酸，甲酸，葡萄糖酸，丙酸，丙酸，丁酸， 衣康酸及其混合物。 本发明的一个实施方案涉及从水溶液如发酵浴中回收2-酮-L-古洛糖酸（KLG）。

公开(公告)号：US06518454B1

公开(公告)日：2003-02-11

申请号：US09975872

申请日：2001-10-12

申请人： Bhaskar Krishna Arumugam ,  Larry Wayne Blair ,  Brendan William Boyd ,  Nick Allen Collins ,  David Anthony Larkin ,  Steven Thomas Perri ,  Chester Wayne Sink

发明人： Bhaskar Krishna Arumugam ,  Larry Wayne Blair ,  Brendan William Boyd ,  Nick Allen Collins ,  David Anthony Larkin ,  Steven Thomas Perri ,  Chester Wayne Sink

IPC分类号： C07C6702

CPC分类号： C07C67/08 ,  C07C69/68 ,  C07C69/716

摘要： Disclosed is a process wherein a solution of a carboxylic acid in a first solvent and an alcohol are fed to a simulated moving bed reactor (SMBR) containing a solid(s) to produce a first stream comprising a solution of an ester of the carboxylic acid and the alcohol and a second stream comprising the first solvent. The solid(s) present in the SMBR facilitates the esterification reaction and the separation of the first solvent from the carboxylic acid. The process is particularly valuable for the preparation of an alkanol solution of an alkyl 2-keto-L-gulonate ester (AKLG) from an aqueous fermentation broth containing dissolved 2-keto-L-gulonic acid (KLG) by feeding the fermentation broth and an alkanol to a simulated moving bed reactor which contains a solid acidic esterification catalyst to produce a stream comprising an alkanol solution of an ALKG. The alkanol solution of an ALKG may be used directly to convert the ALKG to ascorbic acid (Vitamin C).

摘要翻译： 公开了一种方法，其中将羧酸在第一溶剂和醇中的溶液进料到含有固体的模拟移动床反应器（SMBR）中以产生包含羧酸的酯溶液的第一物流 所述醇和包含所述第一溶剂的第二物流。 存在于SMBR中的固体促进酯化反应和第一溶剂与羧酸的分离。 该方法对于通过加入发酵液从含有溶解的2-酮-L-古洛糖酸（KLG）的水性发酵液中制备2-酮-L-古洛糖酸烷基酯（AKLG）的链烷醇溶液是特别有价值的， 将链烷醇加入到含有固体酸性酯化催化剂以产生包含ALKG的链烷醇溶液的流的模拟移动床反应器中。 ALKG的链烷醇溶液可以直接用于将ALKG转化为抗坏血酸（维生素C）。

公开(公告)号：US06476239B1

公开(公告)日：2002-11-05

申请号：US10074829

申请日：2002-02-12

申请人： Bhaskar Krishna Arumugam ,  Steven Thomas Perri ,  Elaine Beatrice Mackenzie ,  Larry Wayne Blair ,  Joseph Robert Zoeller

发明人： Bhaskar Krishna Arumugam ,  Steven Thomas Perri ,  Elaine Beatrice Mackenzie ,  Larry Wayne Blair ,  Joseph Robert Zoeller

IPC分类号： C07D30762

CPC分类号： C07D307/62

摘要： The present invention is a process for the preparation of ascorbic acid using a simulated moving bed (SMB) reactor system to accomplish the simultaneous conversion of KLG or a derivative of KLG to ascorbic acid and the separation of reaction products. The SMB reactor contains a solid or mixture of solids effective for catalyzing the reaction of KLG or its derivative and for separating the reactions products by selective adsorption of at least one product. In a general embodiment, this process involves (1) feeding a solution of KLG or a derivative thereof in a first solvent and a desorbent which is miscible with the first solvent, to a simulated moving bed reactor; (2) reacting the KLG or the KLG derivative to form ascorbic acid; and (3) removing from the simulated moving bed reactor (i) a first liquid stream comprising a solution of ascorbic acid in the desorbent and the first solvent (ii) a second liquid stream comprising the first solvent and the desorbent.

摘要翻译： 本发明是使用模拟移动床（SMB）反应器系统制备抗坏血酸的方法，以实现KLG或KLG的衍生物同时转化为抗坏血酸和分离反应产物。 SMB反应器含有对催化KLG或其衍生物的反应有效的固体或固体混合物，并且通过选择性吸附至少一种产物来分离反应产物。 在一般实施方案中，该方法包括（1）将KLG或其衍生物的溶液送入模拟移动床反应器中的第一溶剂和可与第一溶剂混溶的解吸剂; （2）使KLG或KLG衍生物反应形成抗坏血酸; （3）从模拟移动床反应器（i）中除去包含解吸剂中的抗坏血酸溶液的第一液体流和第一溶剂（ii）包含第一溶剂和解吸剂的第二液体流。