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公开(公告)号:US07414134B2
公开(公告)日:2008-08-19
申请号:US11247050
申请日:2005-10-11
IPC分类号: C07D211/04 , C07D261/08 , C07D249/04 , C07D249/06
CPC分类号: C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译: 本发明包括新颖的化合物及其药学上可接受的衍生物,用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号:US07612060B2
公开(公告)日:2009-11-03
申请号:US11247046
申请日:2005-10-11
申请人: Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
发明人: Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
IPC分类号: C07D403/00 , C07D401/00 , C07D413/00 , A01N43/46 , A61K31/535 , A61K31/497
CPC分类号: C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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13.
公开(公告)号:US07096819B2
公开(公告)日:2006-08-29
申请号:US09821027
申请日:2001-03-30
CPC分类号: H01J37/32174 , H01J37/321
摘要: An inductive plasma processor includes a multiple winding radio frequency coil having plural electrically parallel, spatially concentric windings (1) having different amounts of RF power supplied to them, and (2) arranged to produce electromagnetic fields having different couplings to different regions of plasma in the chamber to control plasma flux distribution incident on a processed workpiece. The coil is powered by a single radio frequency generator via a single matching network. Input and output ends of each winding are respectively connected to input and output tuning capacitors. In a first embodiment, the location of maximum inductive coupling of the radio frequency to the plasma and the current magnitude in each winding are respectively mainly determined by values of the output and input capacitors. By adjusting all the input and output capacitors simultaneously, the current to a winding can be varied while the current to the other winding can be maintained constant as if these windings were completely de-coupled and independent. Therefore, the capacitors can control the plasma density in different radial and azimuthal regions. In another embodiment, a relatively low frequency drives the coil whereby each winding has a relatively short electrical length, causing substantially small standing wave current and voltage variations. The output capacitor for each winding adjusts current magnitude, to eliminate the need for the input capacitors and reduce operational complexity.
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公开(公告)号:US06580868B2
公开(公告)日:2003-06-17
申请号:US09812358
申请日:2001-03-19
申请人: Jian J. Chen , Jianhua Wang
发明人: Jian J. Chen , Jianhua Wang
IPC分类号: G02B600
摘要: A mechanically-adjustable variable optical attenuator includes a beam attenuator shaped as a concave quasi-cone. The beam attenuator has a sharp tip and a base, and can be rotationally symmetric with respect to a central axis extending between the tip and the base. The beam attenuator is positioned with its central axis perpendicular to the direction of the light beam to be attenuated. The extent of the beam attenuator obstructing the light beam is varied by moving the beam attenuator into and out of the light beam. The inwardly-curving, quasi-cone shape of the beam attenuator allows achieving a high resolution while limiting the beam attenuator size.
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公开(公告)号:US08710043B2
公开(公告)日:2014-04-29
申请号:US13529860
申请日:2012-06-21
申请人: Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
发明人: Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
IPC分类号: C07D498/04 , C07D401/12 , C07D471/04 , C07D213/81
CPC分类号: C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译: 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症,并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构:其中本文提供变量的定义。
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公开(公告)号:US08480991B2
公开(公告)日:2013-07-09
申请号:US12670263
申请日:2008-07-23
申请人: Scott Nichol , Jian J. Chen
发明人: Scott Nichol , Jian J. Chen
IPC分类号: C01B33/02
CPC分类号: C30B9/10 , C01B33/037 , C30B29/06
摘要: A method for purifying silicon wherein silicon is crystallized from a solvent metal. The method comprises the steps of providing a molten liquid containing silicon, a solvent metal and impurities, cooling the molten liquid to form first silicon crystals and a first mother liquor, separating the first silicon crystals from the first mother liquor, contacting the first silicon crystals with compound which will dissolve the first mother liquor and separating the washed crystals from the wash solution.
摘要翻译: 一种纯化硅的方法,其中硅从溶剂金属中结晶。 该方法包括以下步骤:提供含有硅,溶剂金属和杂质的熔融液体,冷却熔融液体以形成第一硅晶体和第一母液,将第一硅晶体与第一母液分离,使第一硅晶体 用化合物溶解第一母液并将洗涤的晶体与洗涤溶液分离。
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17.
公开(公告)号:US07989461B2
公开(公告)日:2011-08-02
申请号:US11643261
申请日:2006-12-20
申请人: Frenel F. De Morin , Jian J. Chen , Stephen Hitchcock , Gang Liu , Nick A. Paras , Jeffrey Petkus , Adrian L. Smith , Andrew Tasker , Jiawang Zhu
发明人: Frenel F. De Morin , Jian J. Chen , Stephen Hitchcock , Gang Liu , Nick A. Paras , Jeffrey Petkus , Adrian L. Smith , Andrew Tasker , Jiawang Zhu
IPC分类号: A61K31/517
CPC分类号: C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括能够调节Raf激酶的新一类化合物,因此可用于治疗Raf激酶介导的疾病,包括黑素瘤,肿瘤和其它癌症相关病症。 该化合物具有通式I,其中R1为和A1,A2,A3,A4,X,Z,Z',R1,R2,R3,R4,R5和R6如本文所定义。 本发明还包括药物组合物,用于治疗Raf激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US20080249106A1
公开(公告)日:2008-10-09
申请号:US12082076
申请日:2008-04-08
申请人: Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
发明人: Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
IPC分类号: A61K31/496 , C07D249/06 , A61K31/4192 , A61K31/454 , C07D401/08 , C07D403/08
CPC分类号: C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译: 本发明包括新颖的化合物及其药学上可接受的衍生物,用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号:US06904223B1
公开(公告)日:2005-06-07
申请号:US10408073
申请日:2003-04-04
申请人: Zuyun Fang , Jianhua Wang , Jian J. Chen
发明人: Zuyun Fang , Jianhua Wang , Jian J. Chen
CPC分类号: G02B6/266
摘要: In a preferred embodiment, a motorized variable optical attenuator comprises an input fiber collimator; an output fiber collimator disposed substantially along the first collimator; and a right-angle reflector movable relative to the input collimator and the output collimator along a translation direction forming a non-zero angle with a direction of a light beam emitted by the input collimator. The reflector comprises two mutually-perpendicular reflective surfaces for sequentially reflecting the light beam emitted by the input collimator to the output collimator. A variable attenuation imparted by the attenuator on the light beam is determined by a position of the reflector relative to the input collimator and the output collimator, along the translation direction. The reflector preferably comprises a right-angle prism adhered to a nut mounted on a threaded axle driven by a stepper motor. The attenuator can achieve stable, ripple-free attenuation characteristics at insertion losses beyond −40 dB.
摘要翻译: 在优选实施例中,电动可变光衰减器包括输入光纤准直器; 基本上沿着所述第一准直仪设置的输出光纤准直器; 以及直角反射体,其相对于输入准直器和输出准直器沿着与由输入准直仪发射的光束的方向成非零角度的平移方向移动。 反射器包括两个相互垂直的反射表面,用于将由输入准直仪发射的光束顺序反射到输出准直器。 由衰减器在光束上赋予的可变衰减由反射器相对于输入准直仪和输出准直器沿平移方向的位置确定。 反射器优选地包括附接到安装在由步进马达驱动的螺纹轴上的螺母的直角棱镜。 衰减器可以在插入损耗超过-40 dB时实现稳定的无纹波衰减特性。
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公开(公告)号:US06872281B1
公开(公告)日:2005-03-29
申请号:US09676269
申请日:2000-09-28
申请人: Jian J. Chen , Mukund Srinivasan , Eric H. Lenz
发明人: Jian J. Chen , Mukund Srinivasan , Eric H. Lenz
IPC分类号: H05H1/46 , B01J19/08 , C23F4/00 , H01J37/32 , H01L21/205 , H01L21/3065 , C23C16/00 , C23F1/00
CPC分类号: H01J37/32871 , H01J37/32082 , H01J37/32623
摘要: A plasma confining assembly for minimizing unwanted plasma formations in regions outside of a process region in a process chamber is disclosed. The plasma confining assembly includes a first confining element and second confining element positioned proximate the periphery of the process region. The second confining element is spaced apart from the first confining element. The first confining element includes an exposed conductive surface that is electrically grounded and the second confining element includes an exposed insulating surface, which is configured for covering a conductive portion that is electrically grounded. The first confining element and the second confining element substantially reduce the effects of plasma forming components that pass therebetween. Additionally, the plasma confining assembly may include a third confining element, which is formed from an insulating material and disposed between the first confining element and the second confining element, and proximate the periphery of the process region. The third confining element further reduces the effects of plasma forming components that pass between the first confining element and the second confining element.
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