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11.发明授权Biphenyl compounds useful in the treatment or prevention of cardiovascular disorders 有权用于治疗或预防心血管疾病的联苯化合物公开(公告)号：US07998988B2
公开(公告)日：2011-08-16
申请号：US12083760
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
IPC分类号： A01N43/82
CPC分类号： C07D271/07 , C07D249/12 , C07D249/14 , C07D271/113
摘要： The invention relates to biphenyl compounds of formula (I): wherein U, V and W together form a group of the formula *—CH═CH—CH
摘要翻译： 本发明涉及式（I）的联苯化合物：其中U，V和W一起形成式* -CH = CH-CH <，* -CH2-CH2-CH <或* -CH2-CH2-N ，其中*表示与苯环的连接点; A是O或CH2; 和D，E，X，Y，Z，R1，R2，o，n和p如说明书中所定义。 本发明还涉及化合物的化合物的药物组合物。 本发明的化合物和药物组合物可用于治疗或预防心血管疾病。
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12.发明申请公开(公告)号：US20110034450A1
公开(公告)日：2011-02-10
申请号：US12937995
申请日：2009-04-06
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
IPC分类号： A61K31/5395 , C07D237/32 , C07D273/04 , C07D271/113 , C07D253/075 , C07D263/22 , C07D211/76 , C07D401/12 , C07D405/12 , C07D277/34 , A61K31/502 , A61K31/4245 , A61K31/53 , A61K31/421 , A61K31/451 , A61K31/426 , A61P7/02 , A61P9/12 , A61P3/00 , A61P9/04 , A61P9/10
CPC分类号： C07D237/32 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/075 , C07D253/08 , C07D261/20 , C07D263/20 , C07D271/113 , C07D273/04 , C07D275/06 , C07D277/34 , C07D417/12
摘要： The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环状部分结构的新型羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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13.发明申请Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases 有权具有羧基等排基团的杂环化合物及其用于治疗心血管疾病的用途公开(公告)号：US20090227640A1
公开(公告)日：2009-09-10
申请号：US12083760
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Klaus Münter , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder
IPC分类号： A61K31/4245 , A61K31/4196 , C07D271/07 , C07D249/12
CPC分类号： C07D271/07 , C07D249/12 , C07D249/14 , C07D271/113
摘要： The present application relates to novel heterocyclic compounds, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型杂环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病尤其是用于治疗和/或预防的药物的用途 的心血管疾病。
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14.发明授权Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof 有权取代的4-芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US08436180B2
公开(公告)日：2013-05-07
申请号：US12526951
申请日：2008-02-19
申请人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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15.发明申请SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF 有权取代的4-亚芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US20100136142A1
公开(公告)日：2010-06-03
申请号：US12526951
申请日：2008-02-19
申请人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： A61K33/00 , C07D471/04 , A61K31/4375 , A61P7/12 , A61P1/16 , A61P9/10 , A61P9/12 , A61P13/12 , A61K31/60 , A61K31/704
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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16.发明授权公开(公告)号：US08404709B2
公开(公告)日：2013-03-26
申请号：US12303719
申请日：2007-06-01
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr , Adam Nitsche
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr , Adam Nitsche
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-萘啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备药物的用途 治疗和/或预防疾病，特别是心血管疾病。
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17.发明申请公开(公告)号：US20100305052A1
公开(公告)日：2010-12-02
申请号：US12303719
申请日：2007-06-01
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr
IPC分类号： A61K31/7048 , C07D471/04 , A61K31/4375 , A61K31/60 , A61P9/10 , A61P1/16 , A61P13/12 , A61P9/00 , A61P5/40 , A61P9/12
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-萘啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备药物的用途 治疗和/或预防疾病，特别是心血管疾病。
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公开(公告)号：US08487111B2
公开(公告)日：2013-07-16
申请号：US12665718
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatmann , Julia Straβburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatmann , Julia Straβburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/44 , C07D413/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
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19.发明授权Endothelin antagonist and beta receptor blocking agent as combined preparations 有权内皮素拮抗剂和β受体阻断剂作为联合制剂公开(公告)号：US06352992B1
公开(公告)日：2002-03-05
申请号：US09508989
申请日：2000-03-20
申请人： Michael Kirchengast , Klaus Münter
发明人： Michael Kirchengast , Klaus Münter
IPC分类号： A61K31505
CPC分类号： A61K45/06
摘要： A combination of endothelin antagonists and beta-receptor blockers is described. The combination is suitable for controlling diseases.
摘要翻译： 描述了内皮素拮抗剂和β-受体阻滞剂的组合。 该组合适用于控制疾病。
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公开(公告)号：US20100261759A1
公开(公告)日：2010-10-14
申请号：US12665718
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/4439 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
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