专利检索 ap:("Santiago Figueroa Perez" OR "Peter Kolkhof" OR "Lars Bärfacker" OR "Ingo Flamme" OR "Karl-Heinz Schlemmer" OR "Rolf Grosser" OR "Klaus Münter" OR "Andreas Knorr") AND inv:"Andreas Knorr" 第 1 页

1.

发明申请
5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS 有权
标题翻译： 5-ARYL取代的二氢吡啶并嘧啶和二羟基吡啶并将其用作矿物质抗坏血酸

公开(公告)号：US20100035902A1

公开(公告)日：2010-02-11

申请号：US12303369

申请日：2007-05-25

申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr

发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr

IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P9/12

CPC分类号： C07D471/04

摘要： The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

摘要翻译： 本申请涉及新的芳基取代的杂双环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病尤其是心血管疾病的药物的用途疾病

2.

发明授权
Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof 有权
标题翻译：取代的4-芳基-1,4-二氢-1,6-萘啶及其用途

公开(公告)号：US08404709B2

公开(公告)日：2013-03-26

申请号：US12303719

申请日：2007-06-01

申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr , Adam Nitsche

发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr , Adam Nitsche

IPC分类号： A01N43/42 , A61K31/44 , C07D471/02

CPC分类号： C07D471/04

摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-萘啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备药物的用途治疗和/或预防疾病，特别是心血管疾病。

3.

发明申请
SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF 有权
标题翻译：取代的4-芳基-1,4-二氢-1,6-萘啶并及其用途

公开(公告)号：US20100305052A1

公开(公告)日：2010-12-02

申请号：US12303719

申请日：2007-06-01

申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr

发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Rolf Grosser , Klaus Münter , Andreas Knorr

IPC分类号： A61K31/7048 , C07D471/04 , A61K31/4375 , A61K31/60 , A61P9/10 , A61P1/16 , A61P13/12 , A61P9/00 , A61P5/40 , A61P9/12

CPC分类号： C07D471/04

摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-萘啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备药物的用途治疗和/或预防疾病，特别是心血管疾病。

4.

发明授权
Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same 有权
标题翻译：芳基或杂芳基取代的吡啶并[2,3-d]嘧啶及其药物组合物

公开(公告)号：US08399471B2

公开(公告)日：2013-03-19

申请号：US12303369

申请日：2007-05-25

申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr

发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr

IPC分类号： C07D471/04 , A61K32/519 , A61P9/00

CPC分类号： C07D471/04

摘要： The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is: wherein Ar is an aryl or heteroaryl substituent, and R1, R2, R3, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.

摘要翻译： 本申请涉及式（I）的新型芳基或杂芳基取代的吡啶并[2,3-d]嘧啶，其药物组合物及其制备方法。式（I）是：其中Ar是芳基或杂芳基取代基，R1，R2，R3，Ar，D和E如说明书中所定义。本发明的化合物和组合物可用于治疗和/或预防人和动物的各种疾病，包括醛固酮增多症，高血压，慢性心力衰竭，心肌梗死的后遗症，肝硬化，肾衰竭和中风。

5.

发明授权
Cyclically substituted furopyrimidine derivatives and use thereof 失效
标题翻译：环状取代的呋喃嘧啶衍生物及其用途

公开(公告)号：US08324222B2

公开(公告)日：2012-12-04

申请号：US12086784

申请日：2006-12-08

申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

IPC分类号： C07D491/04 , A61K31/519 , A61P9/00

CPC分类号： C07D491/04

摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

6.

发明授权
Acyclically substituted furopyrimidine derivatives and use thereof 有权
标题翻译：环己基取代的呋喃并嘧啶衍生物及其用途

公开(公告)号：US08183246B2

公开(公告)日：2012-05-22

申请号：US12086783

申请日：2006-12-08

申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00

CPC分类号： C07D491/04

摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

7.

发明申请
Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof 失效
标题翻译：环状取代的呋喃并嘧啶衍生物及其用途

公开(公告)号：US20110124665A1

公开(公告)日：2011-05-26

申请号：US12086784

申请日：2006-12-08

申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

IPC分类号： A61K31/519 , C07D491/048 , A61P9/00

CPC分类号： C07D491/04

摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

8.

发明申请
Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof 有权
标题翻译：全新取代的呋喃并嘧啶衍生物及其用途

公开(公告)号：US20090318475A1

公开(公告)日：2009-12-24

申请号：US12086783

申请日：2006-12-08

申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop

IPC分类号： A61K31/519 , C07D491/048

CPC分类号： C07D491/04

摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。