公开(公告)号：US20090104277A1

公开(公告)日：2009-04-23

申请号：US12279238

申请日：2007-02-21

申请人： Jesper Svenning Kristensen ,  Klaus Gregorius Nielsen ,  Nicolas Otto Krogh

发明人： Jesper Svenning Kristensen ,  Klaus Gregorius Nielsen ,  Nicolas Otto Krogh

IPC分类号： A61K9/14 ,  G01N33/53 ,  A61P1/00

CPC分类号： B01J20/26 ,  A61K31/74 ,  A61K47/58 ,  A61K47/593 ,  B01J20/268 ,  B01J20/3057

摘要： One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.

摘要翻译： 一个方面是改进制备分子印迹聚合物（MIP）颗粒的方法，其中包含不溶性MIP颗粒的初始组合物富集用于结合特定靶分子的那些MIP颗粒，从而从最终组合物排除非结合和弱结合的颗粒 。 富集通常通过使用能够分离颗粒材料或通过凝集的色谱方法来实现。 另一方面是通过使用原始MIP颗粒的延长微粉化来制备改进的不溶性MIP，以期暴露每质量单位MIP颗粒的大量结合位点。 在优选实施例中，组合了两个方面。 所得到的改进的MIP可以用于诊断，分析和治疗目的，特别是作为口服给药的药物，其可以在胃肠道中结合胆固醇和胆汁酸和胆汁酸盐等物质。