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公开(公告)号：US08691517B2
公开(公告)日：2014-04-08
申请号：US12085961
申请日：2006-12-06
IPC分类号： G01N33/543 , G01N33/542 , G01N33/66 , A61B5/145
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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2.发明申请METHODS AND MATERIALS FOR MODULATING START-UP TIME AND AIR REMOVAL IN DRY SENSORS 有权用于调节干燥传感器启动时间和空气去除的方法和材料公开(公告)号：US20130109039A1
公开(公告)日：2013-05-02
申请号：US13478356
申请日：2012-05-23
CPC分类号： G01N33/525 , A61B5/145 , A61B5/14532 , A61B5/1455 , A61B5/14556 , A61B5/14865 , A61B5/6861 , A61B2562/02 , A61B2562/028 , A61B2562/162 , G01N21/77 , G01N33/487
摘要： The invention relates to sensors configured to include compositions disposed in specific regions of the sensor in order to provide the sensors with enhanced functional properties, for example faster start-up times. These compositions include, for example, hygroscopic compositions, gas generating compositions and gas solvating compositions. While typical embodiments of the invention pertain to glucose sensors, the systems, methods and materials disclosed herein can be adapted for use with a wide variety of sensors known in the art.
摘要翻译： 本发明涉及被配置为包括设置在传感器的特定区域中的组合物的传感器，以便为传感器提供增强的功能特性，例如更快的启动时间。 这些组合物包括例如吸湿组合物，气体发生组合物和气体溶剂化组合物。 虽然本发明的典型实施例涉及葡萄糖传感器，但是本文公开的系统，方法和材料可以适用于本领域已知的多种传感器。
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公开(公告)号：US20090187084A1
公开(公告)日：2009-07-23
申请号：US12085961
申请日：2006-12-06
IPC分类号： A61B5/1455 , G01N33/53 , C07H15/00
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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公开(公告)号：US08700113B2
公开(公告)日：2014-04-15
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译： 用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留 但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。
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公开(公告)号：US08478375B2
公开(公告)日：2013-07-02
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1455 , C12Q1/68
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US20130060106A1
公开(公告)日：2013-03-07
申请号：US13478478
申请日：2012-05-23
IPC分类号： A61B5/1459 , G01N30/00 , A61B5/1455
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61M5/1723 , A61M2230/201 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N33/66 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/7733 , G01N2021/775 , G01N2021/7759 , G01N2021/7786 , G01N2333/4724
摘要： An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.
摘要翻译： 光学葡萄糖传感器可以包括具有中空内部并耦合到光纤远端的光纤和葡萄糖透过膜。 膜的中空内部提供了一个容纳竞争性葡萄糖结合亲和力测定的隔室。 该测定可以包括可用染料标记的葡萄糖类似物和可用荧光团标记的葡萄糖受体。 光纤可以包括复合抛物面聚光器尖端，并且隔室可另外容纳设置成面对光纤尖端的反射器。 荧光团标记的测定可以由包括光源和具有一个或多个涂层的过滤器衬底的光学询问系统询问，以实现例如激发过滤器和/或发射过滤器。 询问系统可以被制造为堆叠的平面集成光学系统并且被切成更小的单元。
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公开(公告)号：US20090104277A1
公开(公告)日：2009-04-23
申请号：US12279238
申请日：2007-02-21
CPC分类号： B01J20/26 , A61K31/74 , A61K47/58 , A61K47/593 , B01J20/268 , B01J20/3057
摘要： One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract.
摘要翻译： 一个方面是改进制备分子印迹聚合物（MIP）颗粒的方法，其中包含不溶性MIP颗粒的初始组合物富集用于结合特定靶分子的那些MIP颗粒，从而从最终组合物排除非结合和弱结合的颗粒 。 富集通常通过使用能够分离颗粒材料或通过凝集的色谱方法来实现。 另一方面是通过使用原始MIP颗粒的延长微粉化来制备改进的不溶性MIP，以期暴露每质量单位MIP颗粒的大量结合位点。 在优选实施例中，组合了两个方面。 所得到的改进的MIP可以用于诊断，分析和治疗目的，特别是作为口服给药的药物，其可以在胃肠道中结合胆固醇和胆汁酸和胆汁酸盐等物质。
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公开(公告)号：US09642568B2
公开(公告)日：2017-05-09
申请号：US13478420
申请日：2012-05-23
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/00 , A61B5/145 , A61B5/1473 , G01N21/64 , G01N21/77 , G01N33/66
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/742 , A61M5/1723 , A61M2230/201 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N33/66 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/7733 , G01N2021/775 , G01N2021/7759 , G01N2021/7786 , G01N2333/4724
摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.
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公开(公告)号：US20090131773A1
公开(公告)日：2009-05-21
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US6099804A
公开(公告)日：2000-08-08
申请号：US950362
申请日：1997-10-06
IPC分类号： G01N27/333 , B01D67/00 , C12M1/40 , C12Q1/00 , G01N27/327 , G01N33/48 , G01N33/543 , G01N27/00
CPC分类号： B01D67/0093 , C12Q1/002
摘要： In a sensor for measuring an analyte in a biological sample whose measuring surface is covered by or comprises a membrane, the membrane has free groups on the surface facing the sample. The surface is modified such that a hydrophilic component is immobilized on the surface in such a manner that chains of the hydrophilic component are chemically bonded to free groups on the surface. Thus, the surface is provided with a more hydrophilic character relative to its unmodified state.
摘要翻译： 在用于测量其测量表面被膜覆盖或包含膜的生物样品中的分析物的传感器中，膜在面向样品的表面上具有游离基团。 修饰表面使得亲水组分固定在表面上，使得亲水组分的链与表面上的自由基化学键合。 因此，相对于其未修饰状态，表面被赋予更亲水的特性。
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