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    Genetically modified TFPI and method of treating coagulation using the same
    11.
    发明授权
    Genetically modified TFPI and method of treating coagulation using the same 有权
    遗传修饰的TFPI和使用其的凝血治疗方法

    公开(公告)号：US08912143B2

    公开(公告)日：2014-12-16

    申请号：US13297702

    申请日：2011-11-16

    Applicant: Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    Inventor： Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    IPC: A61K38/57 ,  C07K14/745 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K14/81

    CPC classification number: C07K14/811 ,  A61K38/57

    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.

    Abstract translation: 本发明提供用于抗凝的长半衰期基因修饰的TFPI序列（LTFPI）。 在遗传修饰的TFPI序列上，羧基末端位点241,254,260和261处的赖氨酸被糖蛋白和糖基化位点117,167,228的氨基酸天冬酰胺和糖基化位点174处的氨基酸丝氨酸和苏氨酸取代 和175是替代突变。 本发明还提供了通过来自酵母生产系统的高效LTFPI表达来制备LTFPI的方法。

    Genetically Modified TFPI And Method Of Making The Same
    13.
    发明申请
    Genetically Modified TFPI And Method Of Making The Same 有权
    基因改造TFPI及其制作方法

    公开(公告)号：US20120065135A1

    公开(公告)日：2012-03-15

    申请号：US13297702

    申请日：2011-11-16

    Applicant: Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    Inventor： Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    IPC: A61K38/36 ,  A61P7/02 ,  C07K14/00 ,  C12P21/06 ,  C07H21/04

    CPC classification number: C07K14/811 ,  A61K38/57

    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.

    Abstract translation: 本发明提供用于抗凝的长半衰期基因修饰的TFPI序列（LTFPI）。 在遗传修饰的TFPI序列上，羧基末端位点241,254,260和261处的赖氨酸被糖蛋白和糖基化位点117,167,228的氨基酸天冬酰胺和糖基化位点174处的氨基酸丝氨酸和苏氨酸取代 和175是替代突变。 本发明还提供了通过来自酵母生产系统的高效LTFPI表达来制备LTFPI的方法。

    Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
    14.
    发明授权
    Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same 失效
    编码遗传修饰的组织因子途径抑制剂（TFPI）的核酸及其制备方法

    公开(公告)号：US08088599B2

    公开(公告)日：2012-01-03

    申请号：US12407529

    申请日：2009-03-19

    Applicant: Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    Inventor： Duan Ma ,  Jingui Mu ,  Jiping Wang ,  Huijun Wang ,  Wang Liang

    IPC: C12P21/06 ,  C12N1/00 ,  C12N15/00 ,  C12N15/74

    CPC classification number: C07K14/811 ,  A61K38/57

    Abstract: The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.

    Abstract translation: 本发明提供用于抗凝的长半衰期基因修饰的TFPI序列（LTFPI）。 在遗传修饰的TFPI序列上，羧基末端位点241,254,260和261处的赖氨酸被糖蛋白和糖基化位点117,167,228的氨基酸天冬酰胺和糖基化位点174处的氨基酸丝氨酸和苏氨酸取代 和175是替代突变。 本发明还提供了通过来自酵母生产系统的高效LTFPI表达来制备LTFPI的方法。

    Method for the use of hydrophobic bleaching systems in cold batch textile preparation
    18.
    发明授权
    Method for the use of hydrophobic bleaching systems in cold batch textile preparation 有权

    公开(公告)号：US06569209B2

    公开(公告)日：2003-05-27

    申请号：US09794383

    申请日：2001-02-27

    Applicant: Jiping Wang ,  Elizabeth Ann Eggert

    Inventor： Jiping Wang ,  Elizabeth Ann Eggert

    IPC: D06L316

    CPC classification number: C11D3/3907 ,  D06L4/12 ,  D06L4/13 ,  D06L4/15

    Abstract: A method for the treatment of a non-finished textile component in a cold batch process is provided. The method comprises the steps of treating a non-finished textile component in an aqueous bleaching solution of hydrogen and a hydrophobic bleach activator or hydrophobic peracid followed by a treatment time of from about 1 hour to about 15 hours at a temperature of 35° C. or less. Preferred bleach activators include the alkanoyloxybenzene sulfonates and in particular noanoyloxybenzene sulfonate. The method provides acceptable whiteness and superior fiber protection and fabric strength benefits in significantly reduced treatment times versus conventional.

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