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35 条记录 (耗时 0.033 秒)

    Penem derivatives
    14.
    发明授权
    Penem derivatives 失效
    Penem衍生物

    公开(公告)号：US5036063A

    公开(公告)日：1991-07-30

    申请号：US440797

    申请日：1989-11-24

    申请人： Rudolf Lattrell ,  Walter Durckheimer ,  Gerhard Seibert

    发明人： Rudolf Lattrell ,  Walter Durckheimer ,  Gerhard Seibert

    IPC分类号： A61K31/43 ,  C07D499/88

    CPC分类号： C07D499/88

    摘要： Penem derivatives of the formula ##STR1## having R.sup.1 equal to 3-oxocyclobutyl and R.sup.2 equal to H or an ester-forming group, pharmaceutical preparations active against bacterial infections and which contain penem derivatives of this type, processes for the preparation of the penem derivatives and the pharmaceutical preparations, and use of the penem derivatives for the control of bacterial infections are described.

    摘要翻译： 具有R1等于3-氧代环丁基和R2等于H或成酯基团的式“IMAGE”的Penem衍生物，对细菌感染有活性的药物制剂，并且含有这种类型的penin衍生物，penem衍生物的制备方法 并描述了药物制剂以及青霉烯衍生物用于控制细菌感染的用途。

    Antimalarial compositions
    17.
    发明授权
    Antimalarial compositions 失效

    公开(公告)号：US4260615A

    公开(公告)日：1981-04-07

    申请号：US954900

    申请日：1978-10-26

    申请人： Wolfgang Raether ,  Walter Durckheimer ,  Hans Seidenath

    发明人： Wolfgang Raether ,  Walter Durckheimer ,  Hans Seidenath

    IPC分类号： C07D219/06 ,  A61K31/44 ,  A61K31/445 ,  A61K31/47 ,  A61K31/49 ,  A61K31/505 ,  A61K31/53 ,  A61K31/635 ,  A61P33/02 ,  A61K31/435

    CPC分类号： A61K31/635 ,  A61K31/44 ,  A61K31/47 ,  A61K31/49 ,  A61K31/505 ,  A61K31/53 ,  Y10S514/895

    摘要： Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I ##STR1## in which R.sup.1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl,R.sup.2 represents hydrogen or methyl, andR.sup.3 represents fluorine or chlorine,or a salt of such a compound with a physiologically compatible acid or base, with(a) 6-methoxy-.alpha.-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine),(b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine),(c) .alpha.-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine),(d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine),(e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine),(f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil),(g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim),(h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or(i) 4,4'-diaminodiphenylsulfone (Dapsone),or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.