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    Substituted pyrrolidinyl-benzoic acid derivatives and a process for their manufacture
    1.
    发明授权
    Substituted pyrrolidinyl-benzoic acid derivatives and a process for their manufacture 失效
    取代的吡咯烷基 - 苯甲酸衍生物及其制备方法

    公开(公告)号：US4492710A

    公开(公告)日：1985-01-08

    申请号：US421030

    申请日：1982-09-22

    Applicant: Wulf Merkel ,  Dieter Bormann ,  Roman Muschaweck

    Inventor： Wulf Merkel ,  Dieter Bormann ,  Roman Muschaweck

    IPC: C07D207/06 ,  A61K31/40 ,  A61K31/4025 ,  A61P7/10 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D213/65 ,  C07D295/02 ,  C07D295/033 ,  C07D401/12 ,  C07D409/10 ,  A61K31/44

    CPC classification number: C07D207/327 ,  C07D213/65 ,  C07D295/033 ,  Y10S514/869

    Abstract: What are disclosed are pyrrolidinylsulfamoylbenzoic acid compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 denote C.sub.1 -C.sub.4 alkyl and one of the radicals R.sup.1 or R.sup.2 may be hydrogen, R.sup.3 and R.sup.3' denote hydrogen or C.sub.1 -C.sub.4 alkyl or together denote a C--C linkage, R.sup.4 and R.sup.4' denote hydrogen, halogen, CF.sub.3, alkyl or C.sub.1 -C.sub.2 alkoxy, hydroxy, amino or dimethylamino in the various positions of the aryl nucleus, or together denote 3,4-methylenedioxy, R.sup.5 and R.sup.6 denote hydrogen, C.sub.1 -C.sub.4 alkyl or benzyl, Ar denotes phenyl or a 5-membered or 6-membered heteroaromatic ring containing a O, S or N atom and X is omitted or denotes oxygen, sulfur, NH, or CH.sub.2, and their pharmaceutically acceptable salts with bases or acids. The compounds and salts have a salidiuretic action and can be used for the treatment of edematous diseases.

    Abstract translation: 所公开的是式“IMAGE”的吡咯烷基氨磺酰基苯甲酸化合物，其中R 1和R 2表示C 1 -C 4烷基，基团R 1或R 2中的一个可以是氢，R 3和R 3'表示氢或C 1 -C 4烷基或一起表示CC键 ，R4和R4'表示芳基核的各个位置的氢，卤素，CF 3，烷基或C 1 -C 2烷氧基，羟基，氨基或二甲基氨基，或一起表示3,4-亚甲二氧基，R 5和R 6表示氢，C 1 -C 4烷基 或苄基，Ar表示苯基或含有O，S或N原子的5元或6元杂芳环，省略X，或表示氧，硫，NH或CH 2，以及它们与碱或酸的药学上可接受的盐。 所述化合物和盐具有salitiuretic作用，可用于治疗水肿性疾病。

    Thienylbenzoic acid derivatives
    2.
    发明授权
    Thienylbenzoic acid derivatives 失效
    噻吩基苯甲酸衍生物

    公开(公告)号：US4393072A

    公开(公告)日：1983-07-12

    申请号：US418649

    申请日：1982-09-16

    Applicant: Wulf Merkel ,  Dieter Bormann ,  Dieter Mania ,  Roman Muschaweck

    Inventor： Wulf Merkel ,  Dieter Bormann ,  Dieter Mania ,  Roman Muschaweck

    IPC: A61K31/38 ,  A61K31/381 ,  A61P7/10 ,  A61P9/12 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D409/12

    CPC classification number: C07D333/24 ,  Y10S514/87

    Abstract: The invention provides thienylbenzoic acid derivatives of the formula I ##STR1## in which R.sup.1 is an alkyl radical having from 1 to 3 carbon atoms, a phenyl, thienyl or furyl radical optionally substituted by halogen, CF.sub.3, CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydrogen, halogen or CH.sub.3 ; R.sup.3 is hydrogen or alkyl having from 1 to 4 carbon atoms or benzyl; and n is 1 or 2; and the pharmaceutically tolerable salts thereof with acids or bases.

    Abstract translation: 本发明提供式I（I）的噻吩基苯甲酸衍生物，其中R 1是具有1至3个碳原子的烷基，任选被卤素，CF 3，CH 3或OCH 3取代的苯基，噻吩基或呋喃基; R2是氢，卤素或CH3; R3是氢或具有1至4个碳原子的烷基或苄基; n为1或2; 及其与酸或碱的药学上可接受的盐。

    Heat exchanger for cooling a hot gas that contains solid particles
    10.
    发明申请
    Heat exchanger for cooling a hot gas that contains solid particles 有权
    用于冷却含有固体颗粒的热气体的热交换器

    公开(公告)号：US20060131005A1

    公开(公告)日：2006-06-22

    申请号：US11254000

    申请日：2005-10-19

    Applicant: Carsten Birk ,  Dieter Bormann

    Inventor： Carsten Birk ,  Dieter Bormann

    IPC: F28F19/02

    CPC classification number: F28F19/02 ,  F28F9/18

    Abstract: A heat exchanger for cooling a hot gas that contains solid particles, comprising heat exchanger tubes through which the hot gas flows, with the tubes being surrounded by a casing, and with ends of the tubes being welded, via weld seams, into bores of respective tube plates disposed at the ends of the casing. A protective layer coats the end face of the gas inlet side tube plate, an inner wall of the bores, the weld seams, and an inlet region of the heat exchanger tubes. The protective layer comprises a metallic adhesive layer, a high temperature and erosion resistant ceramic layer, and a high temperature and erosion resistant metal layer disposed between the adhesive layer and the ceramic layer.

    Abstract translation: 一种用于冷却包含固体颗粒的热气体的热交换器，包括热气体流过热交换器管，管被壳体包围，并且管的端部通过焊缝焊接到相应的孔中 管板设置在壳体的端部。 保护层涂覆气体入口侧管板的端面，孔的内壁，焊缝和热交换器管的入口区域。 保护层包括金属粘合剂层，耐高温和耐腐蚀的陶瓷层，以及设置在粘合剂层和陶瓷层之间的耐高温和耐腐蚀的金属层。

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