公开(公告)号：US09302980B2

公开(公告)日：2016-04-05

申请号：US14375975

申请日：2013-01-21

Applicant: KANEKA CORPORATION

Inventor： Masatoshi Ohnuki ,  Akira Nishiyama

IPC: C07C205/00 ,  C07C227/18 ,  C07C227/42 ,  C07D207/16 ,  C07D211/60

CPC classification number: C07C227/18 ,  C07C227/42 ,  C07C2601/02 ,  C07D207/16 ,  C07D211/60 ,  C07C229/06 ,  C07C229/08 ,  C07C229/12 ,  C07C229/32 ,  C07C229/48

Abstract: The problem to be solved by the present invention is to easily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals.The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent.The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.

Abstract translation: 本发明要解决的问题是容易且有效地生产具有2-7个碳原子的氨基酸作为高纯度固体而不需要复杂的操作，其可用作药物或农用化学品的合成中间体。 本发明的特征在于包括以高纯度沉淀固体氨基酸的步骤。 在本发明中，将由磺酸和胺组成的副产物盐除去到母液中，使胺与氨基酸的磺酸盐在非质子极性溶剂中反应，或者通过使磺酸与 氨基酸的胺盐在非质子极性溶剂中。 氨基酸的磺酸盐例如可以通过使N-（叔丁氧基羰基）氨基酸与磺酸反应，或者使氨基酸叔丁酯与磺酸反应来制备。