公开(公告)号：US20180093202A1

公开(公告)日：2018-04-05

申请号：US15564888

申请日：2016-04-08

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Conradie

IPC: B01D15/36 ,  B01D15/20 ,  B01D15/18 ,  C07C227/40 ,  C07C229/06 ,  C07C51/47 ,  C07C53/126

CPC classification number: B01D15/362 ,  B01D15/1892 ,  B01D15/20 ,  B01D15/361 ,  C07C51/47 ,  C07C53/126 ,  C07C67/58 ,  C07C227/40 ,  C07C229/06

Abstract: This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further downstream purification.

公开(公告)号：US20170348266A1

公开(公告)日：2017-12-07

申请号：US15519504

申请日：2015-11-12

Applicant: Buck Institute for Research on Aging

Inventor： GARY K. SCOTT ,  CHRISTOPHER C. BENZ

IPC: A61K31/198 ,  A61K31/365 ,  A61K31/496 ,  A61K31/5377 ,  G01N33/574 ,  A61K31/341 ,  A61K31/713 ,  C12N15/113 ,  A61K31/501

CPC classification number: A61K31/198 ,  A61K31/341 ,  A61K31/365 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/713 ,  A61K45/06 ,  C07C229/06 ,  C07C229/20 ,  C07C229/30 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  G01N33/57415 ,  G01N33/57484 ,  G01N2333/9065 ,  G01N2800/52 ,  A61K2300/00

Abstract: In various embodiments a cancer treatment method is provided based on inhibition of proline catabolism. When combined with p53 restoration therapy and/or inhibition of glutaminase, the inhibition of proline catabolism results in a “synthetic lethal” and synergistic anticancer response. Novel suicide inhibitors that induce the degradation of proline dehydrogenase (PRODH) are also provided. Also provided is a method of assaying PRODH to identify responders/non-responders to inhibition of proline catabolism and/or glutaminase.

公开(公告)号：US20170210912A1

公开(公告)日：2017-07-27

申请号：US15329408

申请日：2015-07-29

Applicant: MITSUBISHI MATERIALS CORPORATION ,  Mitsubishi Materials Electronic Chemicals Co., Ltd.

Inventor： Masato Fujita ,  Masakazu Uotani ,  Takeshi Kamiya ,  Tsunetoshi Honda ,  Daisuke Takano

IPC: C09D5/16 ,  B01D17/02 ,  C09D7/00 ,  C07C229/12 ,  C07C227/16 ,  C07C233/05 ,  C07C231/02 ,  C07C311/05 ,  C07C303/38 ,  C07C309/13 ,  C07C303/02 ,  C07D211/38 ,  C07D265/30 ,  C07D207/10 ,  C07D241/04 ,  C02F1/40

CPC classification number: C09D5/1625 ,  B01D17/02 ,  C02F1/40 ,  C07C227/06 ,  C07C227/08 ,  C07C227/16 ,  C07C227/18 ,  C07C229/06 ,  C07C229/12 ,  C07C231/02 ,  C07C231/12 ,  C07C233/05 ,  C07C233/08 ,  C07C303/02 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C309/04 ,  C07C309/13 ,  C07C309/29 ,  C07C311/03 ,  C07C311/05 ,  C07D207/10 ,  C07D211/38 ,  C07D241/04 ,  C07D265/30 ,  C08K5/17 ,  C08L101/00 ,  C09D5/16 ,  C09D7/20 ,  C09D7/40 ,  C09D201/00 ,  C09K3/00 ,  Y02W10/37

Abstract: The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.

公开(公告)号：US20160297747A1

公开(公告)日：2016-10-13

申请号：US15094791

申请日：2016-04-08

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Conradie

IPC: C07C227/40 ,  B01D15/18 ,  B01D15/20 ,  C07C67/58 ,  B01D15/36

CPC classification number: B01D15/362 ,  B01D15/1892 ,  B01D15/20 ,  B01D15/361 ,  C07C51/47 ,  C07C53/126 ,  C07C67/58 ,  C07C227/40 ,  C07C229/06

Abstract: This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further down-stream purification.

Abstract translation: 该文献描述了通过从水溶液经由连续离子交换从而进一步下游纯化的高纯度和高浓度回收单价产物的方法。

公开(公告)号：US20150225439A1

公开(公告)日：2015-08-13

申请号：US14425602

申请日：2013-09-05

Applicant: Victoria Link Limited

Inventor： Phillip Martin Rendle ,  Steven Toms

IPC: C07H15/04 ,  C07C229/06 ,  C07C229/38

CPC classification number: C07H15/04 ,  A61K47/32 ,  A61K47/48192 ,  A61K47/59 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/124 ,  C07C229/06 ,  C07C229/10 ,  C07C229/38 ,  C07C233/18 ,  C07C237/08

Abstract: This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached to, or can encapsulate within, active agent(s) so as to beneficially modify the characteristics of that active agent. Alternatively, the elaborated compounds can themselves be beneficially modified into therapeutic agents by the attachment of inactive agents.

Abstract translation: 本发明涉及某些树枝状大分子化合物。 特别地，本发明涉及新颖的树枝状大分子化合物，其可以被精心制备以产生越来越大的和复杂的化合物。 这些精制化合物可以附着于活性剂或可以包封在活性剂中，以有利地改变该活性剂的特性。 或者，精制的化合物本身可以通过无活性剂的附着而有益地修饰成治疗剂。

公开(公告)号：US20140343289A1

公开(公告)日：2014-11-20

申请号：US14375975

申请日：2013-01-21

Applicant: KANEKA CORPORATION

Inventor： Masatoshi Ohnuki ,  Akira Nishiyama

IPC: C07C227/18 ,  C07D211/60 ,  C07D207/16

CPC classification number: C07C227/18 ,  C07C227/42 ,  C07C2601/02 ,  C07D207/16 ,  C07D211/60 ,  C07C229/06 ,  C07C229/08 ,  C07C229/12 ,  C07C229/32 ,  C07C229/48

Abstract: The problem to be solved by the present invention is to ea lily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals.The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent.The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.

Abstract translation: 本发明要解决的问题是在没有复杂操作的情况下生产具有2-7个碳原子的氨基酸作为高纯度固体，其可用作药物或农用化学品的合成中间体。 本发明的特征在于包括以高纯度沉淀固体氨基酸的步骤。 在本发明中，将由磺酸和胺组成的副产物盐除去到母液中，使胺与氨基酸的磺酸盐在非质子极性溶剂中反应，或者通过使磺酸与 氨基酸的胺盐在非质子极性溶剂中。 氨基酸的磺酸盐例如可以通过使N-（叔丁氧基羰基）氨基酸与磺酸反应，或者使氨基酸叔丁酯与磺酸反应来制备。

公开(公告)号：US20120116106A1

公开(公告)日：2012-05-10

申请号：US13354033

申请日：2012-01-19

Applicant: John Gleason ,  Douglas Jost ,  Philip H. Merrell ,  Doug Caskey

Inventor： John Gleason ,  Douglas Jost ,  Philip H. Merrell ,  Doug Caskey

IPC: C07C57/03 ,  C07F9/09 ,  C07C57/12

CPC classification number: C07D233/64 ,  C07C51/412 ,  C07C53/02 ,  C07C53/10 ,  C07C53/122 ,  C07C53/126 ,  C07C55/08 ,  C07C55/10 ,  C07C55/12 ,  C07C55/14 ,  C07C55/16 ,  C07C57/03 ,  C07C57/10 ,  C07C57/12 ,  C07C57/145 ,  C07C57/15 ,  C07C59/08 ,  C07C59/105 ,  C07C59/19 ,  C07C59/245 ,  C07C59/265 ,  C07C63/06 ,  C07C63/16 ,  C07C65/10 ,  C07C229/06 ,  C07C229/24 ,  C07C229/26 ,  C07C279/14 ,  C07C323/58 ,  C07D307/62 ,  C07F9/091

Abstract: A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets.

Abstract translation: 形成多不饱和脂肪酸和非脂肪酸的共盐作为沉淀物。 形成的共盐是自由流动的，并且在储存中不趋于聚集（饼）。 所得的共盐产品将容易与其他产品混合以产生膳食补充剂。 这些新型共盐产品还可以非常好地加入片剂，并且可以加入到目前的膳食补充剂片剂中。

公开(公告)号：US10081598B2

公开(公告)日：2018-09-25

申请号：US15533576

申请日：2015-12-24

Applicant: Eisai R&D Management Co., Ltd. ,  Sogo Pharmaceutical Co., Ltd.

Inventor： Yuta Suzuki ,  Kenji Hyodo ,  Yohei Tanaka

IPC: A61K31/713 ,  C07D211/62 ,  C12N15/113 ,  C07C229/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/28 ,  C07C229/12 ,  C12N15/09

CPC classification number: C07D211/62 ,  A61K31/713 ,  A61K47/10 ,  A61K47/22 ,  A61K47/28 ,  C07C229/06 ,  C07C229/12 ,  C12N15/09 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14

Abstract: The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180179120A1

公开(公告)日：2018-06-28

申请号：US15854885

申请日：2017-12-27

Applicant: Florida State University Research Foundation, Inc.

Inventor： Kenneth Hanson ,  Suliman A. Ayad ,  Victoria A. Posey

IPC: C07B55/00 ,  C07C309/71 ,  C07C68/06 ,  C07C69/96 ,  C07C227/36 ,  C07C229/06 ,  C07D207/16 ,  C07D209/18

CPC classification number: C07B55/00 ,  C07B2200/07 ,  C07C68/06 ,  C07C69/96 ,  C07C227/36 ,  C07C229/06 ,  C07C269/06 ,  C07C309/65 ,  C07C309/71 ,  C07C2601/14 ,  C07C2602/42 ,  C07D207/16 ,  C07D209/18 ,  C07C271/22

Abstract: Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.

公开(公告)号：US20180037975A1

公开(公告)日：2018-02-08

申请号：US15786289

申请日：2017-10-17

Applicant: Battelle Memorial Institute

Inventor： John G. Frye ,  Kenneth Scott Weil ,  Curt A. Lavender ,  Jin Yong Kim

IPC: C22B34/24 ,  C22C27/02

CPC classification number: C22B34/24 ,  B22F1/0044 ,  B22F9/24 ,  C01B21/38 ,  C01G33/00 ,  C01G39/02 ,  C01G41/02 ,  C01G47/00 ,  C07C229/06 ,  C22C1/045 ,  C22C1/058 ,  C22C27/02 ,  C22C27/04 ,  G01N23/20075

Abstract: Nanocrystalline metal powders comprising tungsten, molybdenum, rhenium or niobium can be synthesized using a combustion reaction. Methods for synthesizing the nanocrystalline metal powders are characterized by forming a combustion synthesis solution by dissolving in water an oxidizer, a fuel, and a base-soluble, ammonium precursor of tungsten, molybdenum, rhenium, or niobium in amounts that yield a soichiometric burn when combusted. The combustion synthesis solution is then heated to a temperature sufficient to substantially remove water and to initiate a self-sustaining combustion reaction. The resulting powder can be subsequently reduced to metal form by heating in a reducing gas environment.