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公开(公告)号：US20190300465A1
公开(公告)日：2019-10-03
申请号：US16445264
申请日：2019-06-19
Applicant: KANEKA CORPORATION
Inventor： Koji MACHIDA , Hiroaki Yasukouchi , Akira Nishiyama
Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.
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公开(公告)号：US11161820B2
公开(公告)日：2021-11-02
申请号：US16810050
申请日：2020-03-05
Applicant: KANEKA CORPORATION
Inventor： Hiroaki Yasukouchi , Akira Nishiyama , Koji Machida
IPC: C07D217/06 , B01J19/18 , C01B32/80 , B01J19/00
Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.
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公开(公告)号：US20200207717A1
公开(公告)日：2020-07-02
申请号：US16810050
申请日：2020-03-05
Applicant: KANEKA CORPORATION
Inventor： Hiroaki Yasukouchi , Akira Nishiyama , Koji Machida
IPC: C07D217/06 , C01B32/80 , B01J19/18 , B01J19/00
Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.
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公开(公告)号：US09982014B2
公开(公告)日：2018-05-29
申请号：US15031135
申请日：2014-10-23
Applicant: Kaneka Corporation , Stealth Bio Therapeutics Corp
Inventor： Yoshinori Hirai , Akira Nishiyama , Masaru Mitsuda
CPC classification number: C07K5/1021 , A61K38/00 , C07B2200/13 , C07K5/1019
Abstract: The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH2), which is an SS peptide. According to the present invention, the desired SS-31 is produced by efficiently synthesizing a tetrapeptide compound as a precursor of SS-31 and improving the tetrapeptide purity by crystallization.
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公开(公告)号：US20160264623A1
公开(公告)日：2016-09-15
申请号：US15031135
申请日：2014-10-23
Applicant: KANEKA CORPORATION , STEALTH PEPTIDES INTERNATIONAL, INC.
Inventor： Yoshinori Hirai , Akira Nishiyama , Masaru Mitsuda
IPC: C07K5/113
CPC classification number: C07K5/1021 , A61K38/00 , C07B2200/13 , C07K5/1019
Abstract: The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH2), which is an SS peptide. According to the present invention, the desired SS-31 is produced by efficiently synthesizing a tetrapeptide compound as a precursor of SS-31 and improving the tetrapeptide purity by crystallization.
Abstract translation: 本发明提供一种SS-31（D-Arg-Dmt-Lys-Phe-NH 2）在SS工业规模上有效生产的方法。 根据本发明，通过有效合成作为SS-31的前体的四肽化合物并通过结晶提高四肽纯度来制备所需的SS-31。
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Patent Agency Ranking
公开(公告)号：US12134600B2
公开(公告)日：2024-11-05
申请号：US17605408
申请日：2020-03-05
Applicant: KANEKA CORPORATION
Inventor： Koji Machida , Hiroaki Yasukouchi , Akira Nishiyama
IPC: C07D213/81
Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.
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公开(公告)号：US10781193B2
公开(公告)日：2020-09-22
申请号：US16244824
申请日：2019-01-10
Applicant: KANEKA CORPORATION
Inventor： Hiroaki Yasukouchi , Masaru Mitsuda , Akira Nishiyama , Makoto Funabashi
IPC: C07D513/02 , C07D301/00 , C07C67/14 , C07C231/02 , C07D263/44 , C07C233/64 , C07D303/16 , C07D235/02 , C07C69/78 , C07D217/06 , C07D471/08
Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.
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公开(公告)号：US20140343289A1
公开(公告)日：2014-11-20
申请号：US14375975
申请日：2013-01-21
Applicant: KANEKA CORPORATION
Inventor： Masatoshi Ohnuki , Akira Nishiyama
IPC: C07C227/18 , C07D211/60 , C07D207/16
CPC classification number: C07C227/18 , C07C227/42 , C07C2601/02 , C07D207/16 , C07D211/60 , C07C229/06 , C07C229/08 , C07C229/12 , C07C229/32 , C07C229/48
Abstract: The problem to be solved by the present invention is to ea lily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals.The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent.The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.
Abstract translation: 本发明要解决的问题是在没有复杂操作的情况下生产具有2-7个碳原子的氨基酸作为高纯度固体，其可用作药物或农用化学品的合成中间体。 本发明的特征在于包括以高纯度沉淀固体氨基酸的步骤。 在本发明中，将由磺酸和胺组成的副产物盐除去到母液中，使胺与氨基酸的磺酸盐在非质子极性溶剂中反应，或者通过使磺酸与 氨基酸的胺盐在非质子极性溶剂中。 氨基酸的磺酸盐例如可以通过使N-（叔丁氧基羰基）氨基酸与磺酸反应，或者使氨基酸叔丁酯与磺酸反应来制备。
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公开(公告)号：US10351538B2
公开(公告)日：2019-07-16
申请号：US15758807
申请日：2016-09-01
Applicant: KANEKA CORPORATION
Inventor： Koji Machida , Akira Nishiyama
IPC: C07D251/24 , C07D251/28 , G02B1/14 , B32B7/02 , G02B5/30
Abstract: The present invention provides methods respectively for producing a 2,4,6-tris(2-hydroxy-3-methyl-4-alkoxyphenyl)-1,3,5-triazine compound and 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine, both of which are improved in yield and quality. The methods according to the present invention are characterized in that a reaction of 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine with an alkylating agent is carried out using a base in the presence of an alcohol or water, and are also characterized in that an ester compound is used as an additive in a reaction of cyanuric chloride with 2-methylresorcinol.
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公开(公告)号：US10919829B2
公开(公告)日：2021-02-16
申请号：US16445264
申请日：2019-06-19
Applicant: KANEKA CORPORATION
Inventor： Koji Machida , Hiroaki Yasukouchi , Akira Nishiyama
IPC: C07C37/74 , B01D3/14 , B01D15/36 , B01J41/12 , C07C37/56 , C07H1/06 , C07D249/08 , C07C69/12 , C07C33/22 , C07C67/03 , C07B61/00
Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.
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