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11.发明授权Method for the separation of S-(−)-amlodipine from racemic amlodipine 失效从外消旋氨氯地平分离S - （ - ） - 氨氯地平的方法公开(公告)号：US08436188B2
公开(公告)日：2013-05-07
申请号：US12447306
申请日：2007-10-26
申请人： Seog Beom Song , Il Hwan Cho , Yong Sik Youn , Dong Kwon Lim
发明人： Seog Beom Song , Il Hwan Cho , Yong Sik Youn , Dong Kwon Lim
IPC分类号： C07D211/26 , C07D211/28 , C07D213/80 , C07D213/803 , A61K31/44
CPC分类号： C07D211/90
摘要： Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.
摘要翻译： 公开了从外消旋氨氯地平分离S - （ - ） - 氨氯地平的方法。 使用廉价的L-酒石酸作为光学拆分剂和DMAC作为溶剂，分离方法允许以高产率从外消旋氨氯地平中分离出S - （ - ） - 氨氯地平，并具有令人满意的对映异构体过量，从而在经济上 有利且适用于大量生产光学异构体。
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12.发明申请METHOD FOR THE SEPARATION OF S-(-)-AMLODIPINE FROM RACEMIC AMLODIPINE 失效用于分离来自种族AMLODIPINE的S - （ - ） - 阿米膦酸的方法公开(公告)号：US20100069445A1
公开(公告)日：2010-03-18
申请号：US12447306
申请日：2007-10-26
申请人： Seog Beom Song , Il Hwan Cho , Yong Sik Youn , Dong Kwon Lim
发明人： Seog Beom Song , Il Hwan Cho , Yong Sik Youn , Dong Kwon Lim
IPC分类号： A61K31/44 , C07D213/80
CPC分类号： C07D211/90
摘要： Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.
摘要翻译： 公开了从外消旋氨氯地平分离S - （ - ） - 氨氯地平的方法。 使用廉价的L-酒石酸作为光学拆分剂和DMAC作为溶剂，分离方法允许以高产率从外消旋氨氯地平中分离出S - （ - ） - 氨氯地平，并具有令人满意的对映异构体过量，从而在经济上 有利且适用于大量生产光学异构体。
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公开(公告)号：US07329780B2
公开(公告)日：2008-02-12
申请号：US10582106
申请日：2004-12-09
IPC分类号： C07C303/40 , C07C311/37
CPC分类号： C07C303/40 , C07B2200/07 , C07C311/46
摘要： Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts with a compound selected from the group consisting of chloroacetic acid, bromoacetic acid, fluoroacetic acid, iodoacetic acid, α-halogenoacetic acid anhydride, and α-halogenoacetyl halide in the presence of a base or an acylating agent.
摘要翻译： 提供制备具有式1或其盐的光学纯化合物的方法。 该方法包括：使（R）-2-（4-甲氧基-3-氨基磺酰基 - 苯基）-1-甲基乙胺或其盐与选自氯乙酸，溴乙酸，氟乙酸，碘乙酸， α-卤代乙酸酐和α-卤代乙酰卤在碱或酰化剂的存在下反应。
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14.发明申请SINGLE NANOPARTICLE HAVING A NANOGAP BETWEEN A CORE MATERIAL AND A SHELL MATERIAL, AND PREPARATION METHOD THEREOF 有权具有核心材料和壳材料的纳米粒子的单一纳米粒子及其制备方法公开(公告)号：US20130330839A1
公开(公告)日：2013-12-12
申请号：US13989709
申请日：2011-11-24
申请人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
发明人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , A61K49/0002 , G01N33/54346 , G01N2021/653
摘要： The present invention is to provide a nanoparticle, which can be used effectively for Raman analysis based on very high amplification effect of electromagnetic signal by plasomonic coupling of nanogap formation inside thereof and high reproducibility, and which includes core and surrounding shell with nanogap formation between the same and the method of synthesis thereof. The present invention is also to provide the method for detecting the analyte using the above nanoparticle and the analyte detection kit including the above nanoparticle.
摘要翻译： 本发明提供一种纳米颗粒，其可以基于电磁信号的非常高的放大效应而有效地用于拉曼分析，其通过等离子体耦合其内部的纳米孔隙形成和高重现性，并且其包括核和周围壳体之间的纳米隙形成 相同的方法及其合成方法。 本发明还提供使用上述纳米颗粒检测分析物的方法和包括上述纳米颗粒的分析物检测试剂盒。
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15.发明申请公开(公告)号：US20130029360A1
公开(公告)日：2013-01-31
申请号：US13514920
申请日：2010-12-10
申请人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
发明人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
CPC分类号： G01N33/54373 , C12Q1/6816 , C12Q1/6834 , C12Q2563/107 , C12Q2563/155 , C12Q2565/628 , G01N33/54346 , C12Q2565/632 , C12Q2563/143 , C12Q2537/125
摘要： The present invention relates to a nanoparticle dimer in which Raman-active molecules are located at a binding portion of the nanoparticle dimer, and more particularly, to a core-shell nanoparticle dimer comprising: a gold or silver core having a surface to which oligonucleotides are bonded; and a gold or silver shell covering the core. In addition, the present invention relates to the core-shell nanoparticle dimer, to a method for preparing same, and to the use thereof.
摘要翻译： 本发明涉及纳米颗粒二聚体，其中拉曼活性分子位于纳米颗粒二聚体的结合部分，更具体地涉及核 - 壳纳米颗粒二聚体，其包含：具有寡核苷酸表面的金或银芯 保税 以及覆盖芯的金或银壳。 此外，本发明涉及核 - 壳纳米颗粒二聚体，其制备方法及其用途。
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16.发明授权Single nanoparticle having a nanogap between a core material and a shell material, and preparation method thereof 有权在芯材和壳材之间具有纳米隙的单一纳米颗粒及其制备方法公开(公告)号：US09482618B2
公开(公告)日：2016-11-01
申请号：US13989709
申请日：2011-11-24
申请人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
发明人： Yung Doug Suh , Jwa Min Nam , Dong Kwon Lim , Ki Seok Jeon
IPC分类号： C12M1/36 , G01N21/65 , G01N33/543 , A61K49/00
CPC分类号： G01N21/658 , A61K49/0002 , G01N33/54346 , G01N2021/653
摘要： The present invention is to provide a nanoparticle, which can be used effectively for Raman analysis based on very high amplification effect of electromagnetic signal by plasomonic coupling of nanogap formation inside thereof and high reproducibility, and which includes core and surrounding shell with nanogap formation between the same and the method of synthesis thereof. The present invention is also to provide the method for detecting the analyte using the above nanoparticle and the analyte detection kit including the above nanoparticle.
摘要翻译： 本发明提供一种纳米颗粒，其可以基于电磁信号的非常高的放大效应而有效地用于拉曼分析，其通过等离子体耦合其内部的纳米孔隙形成和高重现性，并且其包括核和周围壳体之间的纳米隙形成 相同的方法及其合成方法。 本发明还提供使用上述纳米颗粒检测分析物的方法和包括上述纳米颗粒的分析物检测试剂盒。
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