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公开(公告)号:US20090314319A1
公开(公告)日:2009-12-24
申请号:US12476098
申请日:2009-06-01
申请人: David Young , Robert G. Tegel , Richard Bauer
发明人: David Young , Robert G. Tegel , Richard Bauer
CPC分类号: A45B11/00 , A45B17/00 , A45B2200/1063
摘要: Apparatus and methods are provided for holding and tilting an umbrella. The apparatus comprises at least one spring connected to an umbrella pole so that operation of the spring(s) moves the umbrella pole so as to adjust the pole angle of the umbrella. The apparatus also comprises a pivot for the umbrella pole that allows angular motion of the umbrella pole. The apparatus also comprises a rotary bearing capable of rotating around an axis of the umbrella pole. The spring(s) and the pivot can be connected to the rotary bearing. The present apparatus can also include a shade umbrella and an outdoor table. Methods for tilting an umbrella are also provided.
摘要翻译: 提供了用于保持和倾斜伞的装置和方法。 该装置包括连接到伞杆的至少一个弹簧,使得弹簧的操作使伞杆移动,以便调整伞的极角。 该装置还包括用于伞杆的枢轴,其允许伞杆的角运动。 该装置还包括能够围绕伞杆的轴线旋转的旋转轴承。 弹簧和枢轴可以连接到旋转轴承。 本装置还可以包括遮阳伞和室外桌。 还提供了倾斜伞的方法。
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公开(公告)号:US20080083526A1
公开(公告)日:2008-04-10
申请号:US11949939
申请日:2007-12-04
申请人: David Young , John Coates , James Snow
发明人: David Young , John Coates , James Snow
IPC分类号: F28F99/00
CPC分类号: G01K17/06 , F28D1/035 , F28F2200/00 , F28F2265/16 , G01K17/12 , G01K2201/00
摘要: A heat exchanger evaluation system (84) includes a refrigeration subsystem (126) and a platform (94) in communication with the subsystem (126) for attachment of a heat exchanger (32). The system (84) further includes a thermal imaging camera (168) and a monitor (100). A method (180) entails routing a fluid (38) through the heat exchanger (32) via the refrigeration subsystem (126). The camera (168) detects the temperature variation across the heat exchanger (32) as the fluid (38) flows through the heat exchanger, and provides successive thermal images representing the temperature variation responsive to the flow of the fluid (38). The thermal images are utilized to determine an efficacy of the flow through the heat exchanger (32). In particular, a determination can be made as to whether the flow deviates from a pre-determined flow path (79) of the fluid (38) through the heat exchanger.
摘要翻译: 热交换器评估系统(84)包括与用于附接热交换器(32)的子系统(126)连通的制冷子系统(126)和平台(94)。 系统(84)还包括热成像相机(168)和监视器(100)。 方法(180)需要经由制冷子系统(126)将流体(38)路由穿过热交换器(32)。 当流体(38)流过热交换器时,照相机(168)检测穿过热交换器(32)的温度变化,并响应于流体(38)的流动提供代表温度变化的连续热图像。 热图像用于确定通过热交换器(32)的流动的功效。 特别地,可以确定流体是否偏离流体(38)的预定流动路径(79)通过热交换器。
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公开(公告)号:US20080019965A1
公开(公告)日:2008-01-24
申请号:US11777551
申请日:2007-07-13
申请人: David Young , Miyoko Takahashi
发明人: David Young , Miyoko Takahashi
IPC分类号: A61K39/395 , C07K16/18 , G01N33/53
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , G01N33/57484 , G01N33/6854 , G01N2500/00
摘要: The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases. The anti-cancer antibodies can be conjugated to red blood cells obtained from that patient and re-infused for treatment of metastases based upon the recognition that metastatic cancers are usually well vascularized and the delivery of anti-cancer antibodies by red blood cells can have the effect of concentrating the antibodies at the site of the tumor.
摘要翻译: 本发明涉及使用新的筛选范例来生产患者特异性抗癌抗体的方法。 通过使用癌细胞细胞毒性分离抗癌抗体作为终点,该方法使得可以为可用于治疗和诊断目的的个体患者定制抗癌抗体。 本发明还涉及制备抗体的方法及其使用方法。 抗体可以专门针对来自特定患者的一种肿瘤进行制备,并且基于它们的癌细胞细胞毒性和对非癌细胞同时缺乏毒性进行选择。 抗体可用于帮助分期和诊断癌症,并可用于治疗肿瘤转移。 抗癌抗体可以与从该患者获得的红细胞结合,并且基于认识到转移性癌症通常是良好血管化并且红细胞递送抗癌抗体可以具有 将抗体集中在肿瘤部位的作用。
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公开(公告)号:US20070262869A1
公开(公告)日:2007-11-15
申请号:US11782665
申请日:2007-07-25
申请人: David Young , Roger Mick , Vincent Turco , Michael Walsh
发明人: David Young , Roger Mick , Vincent Turco , Michael Walsh
IPC分类号: G08B13/14
CPC分类号: G06K7/10346 , G06K7/10336 , G06K7/10881 , H01Q1/2216 , H01Q1/38 , H01Q7/00
摘要: A preferred embodiment of a hand-held radio frequency identification reader includes a first casing suitable for being grasped by a user, a second casing, and a transceiver housed within one of the first and second casings. The reader also includes an antenna housed within the second casing and communicatively coupled to the transceiver for communicatively coupling the reader to a radio frequency identification tag. The second casing is movably coupled to the first casing so that the second casing can be aligned with the radio frequency identification tag to substantially maximize a read distance of the reader while the first casing is held in a substantially fixed position in relation to the radio frequency identification tag.
摘要翻译: 手持式射频识别读取器的优选实施例包括适于由用户掌握的第一壳体,第二壳体和容纳在第一和第二壳体之一内的收发器。 读取器还包括容纳在第二壳体内并且通信地耦合到收发器的天线,用于将读取器通信地耦合到射频识别标签。 第二壳体可移动地联接到第一壳体,使得第二壳体可以与射频识别标签对准,从而基本上使读取器的读取距离最大化,同时第一壳体相对于射频被保持在基本上固定的位置 识别标签。
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公开(公告)号:US20070202041A1
公开(公告)日:2007-08-30
申请号:US11709444
申请日:2007-02-22
申请人: David Young , Helen Findlay , Susan Hahn , Daad Sayegh
发明人: David Young , Helen Findlay , Susan Hahn , Daad Sayegh
IPC分类号: A61K51/00 , A61K39/395 , A61K38/21 , C07K16/30 , C07K16/46
CPC分类号: C07K16/30 , A61K47/6851 , A61K51/1045 , A61K2039/505
摘要: The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
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公开(公告)号:US20070116911A1
公开(公告)日:2007-05-24
申请号:US11284536
申请日:2005-11-21
申请人: Mark Miller , Juan Aguirre , David Turner , Michael McLeod , David Young
发明人: Mark Miller , Juan Aguirre , David Turner , Michael McLeod , David Young
CPC分类号: B32B27/32 , B32B27/08 , B32B27/327 , B32B2250/242 , B32B2270/00 , B32B2307/31 , B32B2439/00 , C08J5/18 , C08J2323/14 , C08L23/14 , C08L23/142 , C08L2205/02 , C08L2314/06 , Y10T428/1352 , Y10T428/31504 , C08L2666/06 , C08L2666/08
摘要: A film having a seal strength of at least 100 grams force/inch and a seal initiation temperature of less than about 100 ° C. A polymeric composition comprising a metallocene catalyzed random ethylene-propylene copolymer and a propylene/alpha olefin copolymer or ethylene/alpha olefin copolymer. An article comprised of a film having a seal strength of at least 100 grams force/inch and a seal initiation temperature of less than about 100 ° C.
摘要翻译: 具有至少100克力/英寸的密封强度和小于约100℃的密封起始温度的膜。包含金属茂催化的无规乙烯 - 丙烯共聚物和丙烯/α-烯烃共聚物或乙烯/α-烯烃共聚物的聚合物组合物 烯烃共聚物。 一种由具有至少100克力/英寸的密封强度和小于约100℃的密封起始温度的薄膜组成的制品。
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公开(公告)号:US20070031428A1
公开(公告)日:2007-02-08
申请号:US11496669
申请日:2006-07-31
申请人: David Young , Susan Hahn , Lisa Cechetto
发明人: David Young , Susan Hahn , Lisa Cechetto
IPC分类号: A61K39/395 , G01N33/574 , C12N5/06 , C07K16/30
CPC分类号: C07K16/30 , A61K49/0041 , A61K49/0058 , A61K2039/505 , C07K16/3046 , C07K16/3069 , C07K2317/73 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57449
摘要: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号:US20070031427A1
公开(公告)日:2007-02-08
申请号:US11496457
申请日:2006-07-31
申请人: David Young , Susan Hahn , Lisa Cechetto
发明人: David Young , Susan Hahn , Lisa Cechetto
IPC分类号: A61K39/395 , G01N33/574 , C12N5/06 , C07K16/30
CPC分类号: G01N33/57492 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/73 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57438
摘要: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号:US20060240027A1
公开(公告)日:2006-10-26
申请号:US11387115
申请日:2006-03-22
申请人: David Young , Miyoko Takahashi
发明人: David Young , Miyoko Takahashi
IPC分类号: A61K39/395 , C12N5/06
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , G01N33/57484 , G01N33/6854 , G01N2500/00
摘要: The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases. The anti-cancer antibodies can be conjugated to red blood cells obtained from that patient and re-infused for treatment of metastases based upon the recognition that metastatic cancers are usually well vascularized and the delivery of anti-cancer antibodies by red blood cells can have the effect of concentrating the antibodies at the site of the tumor.
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公开(公告)号:US20060081874A1
公开(公告)日:2006-04-20
申请号:US10966491
申请日:2004-10-15
申请人: Daniel Francis , Rashit Nabiev , Richard Ratowsky , David Young , Sunil Thomas , Roman Dimitrov
发明人: Daniel Francis , Rashit Nabiev , Richard Ratowsky , David Young , Sunil Thomas , Roman Dimitrov
IPC分类号: H01L31/109
CPC分类号: H01L31/107 , H01L31/03529 , H01L31/18 , Y02E10/50
摘要: Starved source diffusion methods for forming avalanche photodiodes (APDs) are provided for controlling the edge effect. The edge effect is controlled by reducing edge gain near the edges of an APD active region. This is accomplished by creating a sloped diffusion front near the edges of the active region. The sloped diffusion front is advantageously formed in a single doping step by using a patterned mask during doping. The patterned mask reduces the depth to which dopants diffuse in areas where it only partly covers the underlying layer. By covering more of the underlying layer nearer the edge and progressively less towards the center, the sloped diffusion front is formed. The shallower diffusion depth near the edge reduces the edge gain, and therefore the edge effect. As a result, an APD to fiber misalignment is less likely, and possibility of edge breakdown is greatly reduced.
摘要翻译: 用于形成雪崩光电二极管(APD)的饥饿源扩散方法用于控制边缘效应。 边缘效应通过减少APD有效区域边缘附近的边缘增益来控制。 这是通过在活动区域的边缘附近创建倾斜的扩散前端来实现的。 倾斜的扩散前端有利地通过在掺杂期间使用图案化掩模在单个掺杂步骤中形成。 图案化掩模减少掺杂剂在其仅部分覆盖下层的区域中扩散的深度。 通过覆盖更靠近边缘的下层,并逐渐向中心倾斜,形成倾斜的扩散前沿。 靠近边缘的较浅的扩散深度降低了边缘增益,因此降低了边缘效应。 结果,APD对光纤的未对准不太可能,并且边缘击穿的可能性大大降低。
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