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20 条记录 (耗时 0.035 秒)

    Pyrazole derivatives
    13.
    发明授权
    Pyrazole derivatives 失效

    公开(公告)号：US07230025B2

    公开(公告)日：2007-06-12

    申请号：US10669812

    申请日：2003-09-23

    申请人： Oscar Barba ,  Lyn Howard Jones

    发明人： Oscar Barba ,  Lyn Howard Jones

    IPC分类号： C07D43/02 ,  A61K31/416

    CPC分类号： C07D401/12 ,  C07D231/28 ,  C07D403/12 ,  C07D417/12

    摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodeficiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

    Imidazole Derivatives As Enzyme Reverse Transcriptase Modulators
    20.
    发明申请
    Imidazole Derivatives As Enzyme Reverse Transcriptase Modulators 审中-公开
    咪唑衍生物作为酶逆转录酶调节剂

    公开(公告)号：US20080176919A1

    公开(公告)日：2008-07-24

    申请号：US11813063

    申请日：2005-12-23

    申请人： Lyn Howard Jones ,  Sandra Dora Newman ,  Nigel Alan Swain

    发明人： Lyn Howard Jones ,  Sandra Dora Newman ,  Nigel Alan Swain

    IPC分类号： A61K31/4164 ,  C07D233/84 ,  A61P31/18

    CPC分类号： C07D233/84

    摘要： This invention relates to benzonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, to their use in medicine, and to compositions containing them. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

    摘要翻译： 本发明涉及式（I）的苄腈衍生物或其药学上可接受的盐，溶剂合物或衍生物，其中R 1至R 3在本说明书中定义为其使用 在医学中，以及含有它们的组合物。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。