公开(公告)号：US20080176919A1

公开(公告)日：2008-07-24

申请号：US11813063

申请日：2005-12-23

申请人： Lyn Howard Jones ,  Sandra Dora Newman ,  Nigel Alan Swain

发明人： Lyn Howard Jones ,  Sandra Dora Newman ,  Nigel Alan Swain

IPC分类号： A61K31/4164 ,  C07D233/84 ,  A61P31/18

CPC分类号： C07D233/84

摘要： This invention relates to benzonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, to their use in medicine, and to compositions containing them. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

摘要翻译： 本发明涉及式（I）的苄腈衍生物或其药学上可接受的盐，溶剂合物或衍生物，其中R 1至R 3在本说明书中定义为其使用 在医学中，以及含有它们的组合物。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。

公开(公告)号：US20090264425A1

公开(公告)日：2009-10-22

申请号：US11722181

申请日：2005-12-12

申请人： Lyn Howard Jones ,  Donald Stuart Middleton ,  Charles Eric Mowbray ,  Sandra Dora Newman ,  David Howard Williams

发明人： Lyn Howard Jones ,  Donald Stuart Middleton ,  Charles Eric Mowbray ,  Sandra Dora Newman ,  David Howard Williams

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/437 ,  A61K31/44 ,  C07D413/12 ,  C07D403/04 ,  C07D471/02 ,  C07D213/04

CPC分类号： C07D215/36 ,  C07C311/46 ,  C07D207/12 ,  C07D207/16 ,  C07D211/26 ,  C07D211/42 ,  C07D213/71 ,  C07D213/75 ,  C07D213/89 ,  C07D215/08 ,  C07D215/40 ,  C07D215/48 ,  C07D231/12 ,  C07D231/40 ,  C07D237/20 ,  C07D239/42 ,  C07D241/08 ,  C07D241/20 ,  C07D261/08 ,  C07D271/07 ,  C07D295/185 ,  C07D413/04 ,  C07D471/04

摘要： This invention relates to biaryl ether derivatives of formula (I) wherein R1, R3, R4, X, W, Y and m are defined in the description, and to compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

摘要翻译： 本发明涉及式（I）的联芳基醚衍生物，其中R 1，R 3，R 4，X，W，Y和m在说明书中定义，以及含有它们的组合物及其衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。

公开(公告)号：US20080132549A1

公开(公告)日：2008-06-05

申请号：US10599707

申请日：2005-04-11

申请人： Lyn Howard Jones ,  Shahid Mohammed ,  Sandra Newman ,  Charles Eric Mowbray ,  Matthew Ducan Selby ,  Paul Anthony Stupple ,  Nigel Alan Swain

发明人： Lyn Howard Jones ,  Shahid Mohammed ,  Sandra Newman ,  Charles Eric Mowbray ,  Matthew Ducan Selby ,  Paul Anthony Stupple ,  Nigel Alan Swain

IPC分类号： A61K31/4164 ,  C07D233/84 ,  A61K31/4439 ,  A61P31/18 ,  C07D401/04

CPC分类号： C07D233/84 ,  C07D401/12

摘要： This invention relates to isophthalonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives.The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

摘要翻译： 本发明涉及式（I）的间苯二腈衍生物或其药学上可接受的盐，溶剂合物或衍生物，其中R 1至R 3定义在说明书中， 用于制备它们，用于制备它们的中间体，含有它们的组合物和这些衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。

公开(公告)号：US09216229B2

公开(公告)日：2015-12-22

申请号：US13904432

申请日：2013-05-29

申请人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Lees ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

发明人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Lees ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

IPC分类号： A61K38/04 ,  A61K47/48 ,  A61K39/00 ,  A61K39/395

CPC分类号： A61K47/48338 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/627

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

摘要翻译： 本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

公开(公告)号：US20090253739A1

公开(公告)日：2009-10-08

申请号：US12481891

申请日：2009-06-10

申请人： Kim James ,  Lyn Howard Jones ,  David Anthony Price

发明人： Kim James ,  Lyn Howard Jones ,  David Anthony Price

IPC分类号： A61K31/47 ,  A61K31/18 ,  C07D215/00 ,  C07C311/00

CPC分类号： C07C311/08 ,  C07C215/54 ,  C07C217/48 ,  C07C217/62 ,  C07C223/02 ,  C07C233/43 ,  C07C255/13 ,  C07C271/16 ,  C07C271/66 ,  C07D215/26 ,  C07D215/60 ,  C07F7/1804

摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

公开(公告)号：US08475801B2

公开(公告)日：2013-07-02

申请号：US13564103

申请日：2012-08-01

申请人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

发明人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

IPC分类号： A61K39/00

CPC分类号： A61K47/48338 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/627

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

公开(公告)号：US07109228B2

公开(公告)日：2006-09-19

申请号：US10118512

申请日：2002-04-05

申请人： Lyn Howard Jones ,  Charles Eric Mowbray ,  David Anthony Price ,  Matthew Duncan Selby ,  Paul Anthony Stupple

发明人： Lyn Howard Jones ,  Charles Eric Mowbray ,  David Anthony Price ,  Matthew Duncan Selby ,  Paul Anthony Stupple

IPC分类号： A61K31/415 ,  C07D231/18

CPC分类号： C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04

摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

公开(公告)号：US20140017239A1

公开(公告)日：2014-01-16

申请号：US13904432

申请日：2013-05-29

申请人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

发明人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

IPC分类号： A61K47/48 ,  A61K39/395

CPC分类号： A61K47/48338 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/627

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

摘要翻译： 本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

公开(公告)号：US20120294848A1

公开(公告)日：2012-11-22

申请号：US13564103

申请日：2012-08-01

申请人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

发明人： Alan Daniel Brown ,  Brian Robert Champion ,  Clare Christy ,  David Paul Gervais ,  Lyn Howard Jones ,  Anne Maria Kristina Kjerrstrom ,  David Cameron Pryde ,  Lee Richard Roberts ,  David Michael Wyatt

IPC分类号： C07K17/00 ,  A61K39/395 ,  A61P37/02 ,  C07K16/00

CPC分类号： A61K47/48338 ,  A61K39/00 ,  A61K39/395 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6075 ,  A61K2039/627

摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

摘要翻译： 本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。

公开(公告)号：US07435728B2

公开(公告)日：2008-10-14

申请号：US11157340

申请日：2005-06-20

申请人： Lyn Howard Jones ,  Charles Eric Mowbray ,  David Anthony Price ,  Matthew Duncan Selby ,  Paul Anthony Stupple

发明人： Lyn Howard Jones ,  Charles Eric Mowbray ,  David Anthony Price ,  Matthew Duncan Selby ,  Paul Anthony Stupple

IPC分类号： A01N43/00 ,  A01N43/56 ,  A61K31/00 ,  A61K31/4965 ,  A61K31/535 ,  A61K31/415

CPC分类号： C07D231/12 ,  C07D231/18 ,  C07D231/20 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04

摘要： This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

摘要翻译： 本发明涉及式（I）的吡唑衍生物或其药学上可接受的盐，溶剂化物或衍生物，其中R1至R4在说明书中定义，其制备方法，用于制备含有它们的组合物的中间体和 这种衍生物的用途。 本发明的化合物与酶逆转录酶结合，是调节剂，特别是其抑制剂。 因此，本发明的化合物可用于治疗各种病症，包括其中涉及逆转录酶的抑制的病症。 感兴趣的疾病包括由人免疫缺陷病毒（HIV）引起的遗传相关逆转录病毒，如获得性免疫缺陷综合征（AIDS）。