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公开(公告)号：US20090053205A1
公开(公告)日：2009-02-26
申请号：US12168641
申请日：2008-07-07
申请人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , C07H21/02 , A61K31/7105 , A61K39/00
CPC分类号： A61K39/39 , A61K31/7105 , A61K2039/55561 , C07H21/02 , C12N15/117 , C12N2310/17 , C12N2310/317 , C12N2310/3183 , C12N2310/51 , C12N2320/51
摘要： The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及新型稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供了具有改进的核酸酶和核糖核酸酶稳定性并且通过TLR7和/或TLR8具有免疫调节活性的新型的基于RNA的寡核糖核苷酸。
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公开(公告)号：US20080292648A1
公开(公告)日：2008-11-27
申请号：US11954726
申请日：2007-12-12
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Dong Yu , Lakshmi Bhagat , Daqing Wang , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Dong Yu , Lakshmi Bhagat , Daqing Wang , Sudhir Agrawal
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/336 , C12N2310/3521
摘要： The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical modifications, which provide their distinctive immune response activation profiles.
摘要翻译： 本发明提供了新的基于寡核苷酸的化合物，其通过作为具有TLR9的激动剂的相互作用单独提供不同的免疫应答谱。 根据本发明的TLR9激动剂的特征在于特异性和独特的化学修饰，其提供其独特的免疫应答活化谱。
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公开(公告)号：US20080193437A1
公开(公告)日：2008-08-14
申请号：US11876913
申请日：2007-10-23
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
IPC分类号： A61K39/35 , A61K31/711 , A61K39/395 , A61K38/02 , A61K39/00 , A61K45/00
CPC分类号： A61K31/711 , A61K38/2013 , A61K39/39 , A61K2039/55561 , A61N2005/1098 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/334 , C12N2310/336 , C12N2310/3519 , A61K2300/00
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
摘要翻译： 本发明提供免疫刺激性核酸。 在根据本发明的该方面的某些实施方案中，免疫刺激性寡核苷酸和/或免疫反应物的序列至少部分自身互补。
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公开(公告)号：US07405285B2
公开(公告)日：2008-07-29
申请号：US11234396
申请日：2005-09-22
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
IPC分类号： C07H21/02
CPC分类号： A61K31/711 , A61K38/2013 , A61K39/39 , A61K2039/55561 , A61N2005/1098 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/334 , C12N2310/336 , C12N2310/3519 , A61K2300/00
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
摘要翻译： 本发明提供免疫刺激性核酸。 在根据本发明的该方面的某些实施方案中，免疫刺激性寡核苷酸和/或免疫反应物的序列至少部分自身互补。
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15.发明授权公开(公告)号：US07115579B2
公开(公告)日：2006-10-03
申请号：US09845623
申请日：2001-04-30
申请人： Sudhir Agrawal , Ekambar Kandimalla
发明人： Sudhir Agrawal , Ekambar Kandimalla
CPC分类号： C12N15/117 , A61K38/00 , A61K2039/55561 , C07H21/00 , C12N15/113 , C12N2310/18 , C12N2310/315 , C12N2310/317 , C12N2310/3183 , C12N2310/33 , C12N2310/332 , C12N2310/334 , C12N2310/335 , C12N2310/336 , Y10S514/885
摘要： The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immunostimulatory effect for immunotherapy applications.
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16.发明申请Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy 审中-公开使用免疫刺激性寡核苷酸和/或免疫化合物与细胞因子和/或化学治疗剂或放射治疗联合使用免疫系统的协同刺激公开(公告)号：US20060074040A1
公开(公告)日：2006-04-06
申请号：US10892550
申请日：2004-07-15
申请人： Ekambar Kandimalla , Sudhir Agrawal
发明人： Ekambar Kandimalla , Sudhir Agrawal
CPC分类号： A61K39/39 , A61K38/2013 , A61K2039/55533 , A61K2039/55561 , A61N2005/1098 , C12N15/111 , C12N15/117 , C12N2310/17 , C12N2320/31 , A61K2300/00
摘要： The invention provides optimized methods and compositions for enhancing the immune response caused by immunostimulatory compounds used for the treatment of disease such as, but not limited to, treatment of cancer, autoimmune disorders, asthma, respiratory allergies, food allergies and infectious diseases in a patient. The optimized methods according to the invention provide synergy between the therapeutic effects of immunostimulatory oligonucleotides and immunomer compounds in accordance with the invention, and the therapeutic effect of cytokine immunotherapy and/or chemotherapeutic agents and/or radiation.
摘要翻译： 本发明提供了用于增强用于治疗疾病的免疫刺激化合物引起的免疫应答的优化方法和组合物，所述免疫刺激化合物用于治疗疾病，例如但不限于在患者中治疗癌症，自身免疫疾病，哮喘，呼吸道过敏，食物过敏和感染性疾病 。 根据本发明的优化方法提供了根据本发明的免疫刺激性寡核苷酸和免疫化合物的治疗效果以及细胞因子免疫治疗和/或化学治疗剂和/或辐射的治疗效果之间的协同作用。
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公开(公告)号：US08853375B2
公开(公告)日：2014-10-07
申请号：US12192432
申请日：2008-08-15
CPC分类号： A61K31/711 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K2039/55561 , Y02A50/401 , Y02A50/412 , Y02A50/414
摘要： The invention relates to TLR9 antagonist compounds and their therapeutic or prophylactic use. The invention provides novel immune regulatory oligonucleotides and immunomers as antagonist of TLRs and methods of use thereof. These immune regulatory oligonucleotides have unique sequences that suppress, without completely ablating, TLR-mediated signaling in response to a TLR ligand or TLR signaling agonist. The methods may have use in the prevention and treatment of autoimmunity, inflammation, inflammatory bowel disease, lupus, allergy, asthma, infection, sepsis, cancer and immunodeficiency.
摘要翻译： 本发明涉及TLR9拮抗剂化合物及其治疗或预防用途。 本发明提供新的免疫调节寡核苷酸和作为TLR拮抗剂的免疫体及其使用方法。 这些免疫调节寡核苷酸具有独特的序列，其能够在不完全消除TLR介导的TLR配体或TLR信号激动剂的信号传导的情况下抑制。 该方法可用于预防和治疗自身免疫，炎症，炎性肠病，狼疮，过敏，哮喘，感染，败血症，癌症和免疫缺陷。
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18.发明授权公开(公告)号：US08426375B2
公开(公告)日：2013-04-23
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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公开(公告)号：US07960362B2
公开(公告)日：2011-06-14
申请号：US12183439
申请日：2008-07-31
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译： 本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。 特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。
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20.发明申请POTENT MUCOSAL IMMUNE RESPONSE INDUCED BY MODIFIED IMMUNOMODULATORY OLIGONUCLEOTIDES 审中-公开改性免疫组化寡核苷酸诱导的轻度粘膜免疫应答公开(公告)号：US20110123540A1
公开(公告)日：2011-05-26
申请号：US12952868
申请日：2010-11-23
申请人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
发明人： Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal , Fu-Gang Zhu
IPC分类号： A61K39/395 , A61K39/00 , A61K39/35 , A61K39/39 , A61P37/02
CPC分类号： A61K39/0008 , A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/543 , A61K2039/55561
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers on mucosal innate immunity as well as adjuvant activity using ovalbumin (OVA) as an antigen through administration to the mucosal lining.
摘要翻译： 本发明涉及免疫刺激性寡核苷酸和/或免疫反应物对粘膜先天免疫的治疗用途以及使用卵白蛋白（OVA）作为抗原通过给予粘膜衬里的佐剂活性。
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