摘要:
The present invention relates to compounds of formula (I): pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotraumatic diseases and cancer.
摘要:
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine or cardiac hypertrophy.
摘要:
Novel compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要:
A medical instrument comprising: (a) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in a first degree of freedom; (b) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a second degree of freedom; (c) a pair of repositionable jaws operatively coupled to the first joint and the second joint; (d) an open-ended occlusion clip detachably mounted to the pair of repositionable jaws; and, (e) a controller operatively coupled to the first joint, the second joint, and the pair of repositionable jaws, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member, and a third control configured to direct repositioning of the pair of repositionable jaws, the third control including a line operatively coupled to the first and second jaws in at least a gun tackle pulley configuration
摘要:
The present invention relates to antibodies, immunoglobulin constructs or immunoglobulin IgG4 fusion proteins whose in vivo half-lives are increased by the combination of (i) a modified IgG4 Fc region or FcRn binding domain thereof and (ii) a modified IgG4 hinge region sequence.
摘要:
A burner apparatus (10) for a process heating system (400) includes a combustion air damper (48) to control the volume of air in the combustion chamber (98). Top (15), bottom (17), and sidewalls (14) of the chamber are of steel without refractory material lining while a fuel door (178) is steel with refractory material lining (186). A flue gas damper (34) selectively allows or disallows flue gas out of the chamber. A cooling jacket (18) of a steel sheeting surrounds and is narrowly spaced from the combustion chamber top, bottom, and sidewalls. The cooling jacket conducts air, transfers heat from the combustion chamber top, bottom, and sidewalls to thereby prevent overheating, and generates heated air. A turbulation device (38) combines flue gas and heated air into a turbulent air-gas mixture, completes combustion, and outputs a heated gas stream.
摘要:
A planar antenna includes a ground plane on a substrate, a radiating element coupled to the ground plane on the substrate, and a feed line. An impedance tap point is defined by a connection between the feed line and the radiating element and the length of the radiating element defines the resonant frequency of the antenna. A first portion of the radiating element includes an impedance adjustment mechanism for defining the impedance tap point of the antenna and consequently the impedance of the antenna. A second portion of the radiating element includes a frequency adjustment section which adjusts the length of said radiating element and consequently the resonant frequency of the antenna.
摘要:
A method for incentivizing a user of a social media website to share an offer with others within an online social media environment is provided. The offer includes two coupons, the first coupon having a first value and the second coupon having a second increased value. Sharing of the first coupon provides access to the second coupon and also creates a social media connection between the user and a vendor of the first and second coupons.
摘要:
A wideband tuneable low noise amplifier that is capable of receiving signals over a wide range of frequencies, providing tuneable filtering to remove out of band interferer signals, and providing variable gain for a wide range of frequencies. To accommodate variable gain, the low noise amplifier has an amplifier stage comprising two gain stages, and the relationship between the gain stages is controlled responsive to changes in the voltage gain of an input stage. Linearity monitoring combined with Q-enhance may be employed to increase performance at low signal levels.