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11.发明授权Methods of blocking B-cell activation using anti-CD40 monoclonal antibodies 失效使用抗CD40单克隆抗体阻断B细胞活化的方法公开(公告)号：US06315998B1
公开(公告)日：2001-11-13
申请号：US09504505
申请日：2000-02-15
Applicant: Mark de Boer , Leah B. Conroy
Inventor： Mark de Boer , Leah B. Conroy
IPC: A61K39395
CPC classification number: C07K16/2878 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , C07K2317/24 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
Abstract: Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Abstract translation: 提供了用于预防或治疗患者中抗体介导的死亡酶的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的单克隆抗体，其中所述抗体与 CD40抗原阻止B细胞的生长或分化。 还提出了可用于这些方法的单克隆抗体和与这种单克隆抗体免疫反应的表位。
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公开(公告)号：US06056959A
公开(公告)日：2000-05-02
申请号：US463893
申请日：1995-06-05
Applicant: Mark de Boer , Leah B Conroy
Inventor： Mark de Boer , Leah B Conroy
IPC: C12N15/02 , A61K31/4353 , A61K31/436 , A61K31/573 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/06 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/531 , A61K35/28 , C07K14/435
CPC classification number: C07K16/2878 , A61K39/395 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2799/026
Abstract: Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Abstract translation: 提供了用于预防或治疗患者中抗体介导的死亡酶的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的单克隆抗体，其中所述抗体与 CD40抗原阻止B细胞的生长或分化。 还提出了可用于这些方法的单克隆抗体和与这种单克隆抗体免疫反应的表位。
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Patent Agency Ranking
公开(公告)号：US07790166B2
公开(公告)日：2010-09-07
申请号：US12049850
申请日：2008-03-17
Applicant: Mark de Boer , Leah B. Conroy
Inventor： Mark de Boer , Leah B. Conroy
IPC: A61K39/395 , C07K16/28 , C12N5/12 , A61K39/44
CPC classification number: C07K16/2878 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , C07K2317/24 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
Abstract: Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Abstract translation: 提供了用于预防或治疗患者抗体介导的疾病的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的单克隆抗体，其中所述抗体与 CD40抗原阻止B细胞的生长或分化。 还提出了可用于这些方法的单克隆抗体和与这种单克隆抗体免疫反应的表位。
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公开(公告)号：US6030915A
公开(公告)日：2000-02-29
申请号：US814145
申请日：1997-03-10
Applicant: Mark de Boer
Inventor： Mark de Boer
CPC classification number: C10G45/08 , B01J23/94 , B01J37/0036 , B01J38/00 , B01J38/12 , C10G49/02 , C10G49/16
Abstract: The present invention relates to a process for preparing a hydroprocessing catalyst comprising the steps of subjecting a spent hydroprocessing catalyst comprising carbonaceous and sulphurous deposits to a thermal treatment to remove at least part of said deposits, grinding the thus obtained spent catalyst, mixing the ground hydroprocessing catalyst with at least one additive, and shaping the mixture of additive and ground hydroprocessing catalyst to form particles of a new hydroprocessing catalyst, with the spent hydroprocessing catalyst being subjected to a high-temperature calcination step carried out at a temperature in the range of 550-1000.degree. C. for a period sufficient to increase the MPD of the spent catalyst by at least 0.5 nm.The process according to the invention is particularly suitable for preparing ebullated bed catalysts from spent hydroprocessing catalysts.
Abstract translation: 本发明涉及一种制备加氢处理催化剂的方法，包括以下步骤：将含有碳质和硫酸沉积物的废加氢处理催化剂进行热处理以除去至少部分所述沉积物，研磨由此获得的废催化剂，混合地下加氢处理 具有至少一种添加剂的催化剂，并且对添加剂和研磨加氢处理催化剂的混合物进行成型以形成新的加氢处理催化剂的颗粒，将废加氢处理催化剂进行在550℃范围内的温度下进行的高温煅烧步骤 -1000℃，足以使废催化剂的MPD增加至少0.5nm的时间。 根据本发明的方法特别适用于从废加氢处理催化剂制备沸腾床催化剂。
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15.发明授权Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation 失效人源化抗CD40单克隆抗体和能够阻断B细胞增殖的片段
公开(公告)号：US5874082A
公开(公告)日：1999-02-23
申请号：US606293
申请日：1996-02-23
Applicant: Mark de Boer
Inventor： Mark de Boer
IPC: A61K38/00 , A61K39/395 , A61P37/06 , A61P37/08 , C07K14/705 , C07K16/28
CPC classification number: A61K39/395 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , C07K16/2878 , A61K2039/505 , A61K2039/5154 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N2799/026
Abstract: Methods for preventing or treating an antibody-mediated disease in patient are presented, the methods comprising administration of a humanized monoclonal antibody or fragment thereof that is capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Humanized monoclonal antibodies and fragments useful in these methods are also presented.
Abstract translation: 提供了用于预防或治疗患者抗体介导的疾病的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的人源化单克隆抗体或其片段，其中所述结合 的CD40抗原的抗体阻止B细胞的生长或分化。 还提出了在这些方法中有用的人源化单克隆抗体和片段。
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16.发明授权
公开(公告)号：US5869050A
公开(公告)日：1999-02-09
申请号：US15147
申请日：1993-02-09
Applicant: Mark de Boer , Leah B. Conroy
Inventor： Mark de Boer , Leah B. Conroy
IPC: C12N15/02 , A61K31/4353 , A61K31/436 , A61K31/573 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/06 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/531
CPC classification number: C07K16/2878 , A61K39/395 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2799/026
Abstract: Methods for causing T cell anergy, treating allograft transplant rejection, treating graft versus host disease, and preventing or treating rheumatoid arthritis are presented, the methods comprising co-administration of a molecule that binds to the B7 antigen and an immunosuppressive agent.
Abstract translation: 提出了引起T细胞无反应性的方法，治疗同种异体移植排斥反应，治疗移植物抗宿主病以及预防或治疗类风湿性关节炎的方法，所述方法包括共同施用结合B7抗原的分子和免疫抑制剂。
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17.发明授权
公开(公告)号：US5677165A
公开(公告)日：1997-10-14
申请号：US70158
申请日：1993-05-28
Applicant: Mark de Boer , Leah B. Conroy
Inventor： Mark de Boer , Leah B. Conroy
IPC: C12N15/02 , A61K31/4353 , A61K31/436 , A61K31/573 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/06 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/531 , C12N5/12
CPC classification number: C07K16/2878 , A61K39/395 , C07K14/705 , C07K14/70532 , C07K14/70578 , C07K16/2827 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2799/026
Abstract: Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Abstract translation: 提供了用于预防或治疗患者中抗体介导的死亡酶的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的单克隆抗体，其中所述抗体与 CD40抗原阻止B细胞的生长或分化。 还提出了可用于这些方法的单克隆抗体和与这种单克隆抗体免疫反应的表位。
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