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![6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory](/abs-image/US/2011/10/25/US08044060B2/abs.jpg.150x150.jpg)
11.发明授权6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory 有权6-环基甲基 - 和6-烷基甲基吡唑并[3,4-D]嘧啶，其制备方法及其用于治疗感知，浓度学习和/或记忆损伤的方法公开(公告)号：US08044060B2
公开(公告)日：2011-10-25
申请号：US10556224
申请日：2004-04-28
申请人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P25/16 , A61P25/18
CPC分类号： C07D487/04 , A61K31/519
摘要： Described are 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolo[3,4-d]pyrimidines of the formula (I): as defined herein, processes for their preparation and their use for producing medicaments for treating impairment of perception, concentration, learning and/or memory.
摘要翻译： 描述了式（I）的6-环甲基 - 和6-烷基甲基取代的吡唑并[3,4-d]嘧啶：如本文所定义，其制备方法及其用于制备用于治疗感知，浓度， 学习和/或记忆。
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![6-arylmethylprazolo[3,4-d]pyrimidines](/abs-image/US/2009/11/10/US07615558B2/abs.jpg.150x150.jpg)
公开(公告)号：US07615558B2
公开(公告)日：2009-11-10
申请号：US10556437
申请日：2004-04-27
申请人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04 , A61K31/519
摘要： Described are 6-arylmethylpyrazolo[3,4-d]pyrimidines of the following formula: processes for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 描述了下式的6-芳基甲基吡唑并[3,4-d]嘧啶：其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20080255118A1
公开(公告)日：2008-10-16
申请号：US10586501
申请日：2004-12-31
IPC分类号： A61K31/5377 , A61K31/513 , C07D401/04 , A61P25/28 , C07D413/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08741907B2
公开(公告)日：2014-06-03
申请号：US13193931
申请日：2011-07-29
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving learning and/or memory. The alkyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.
摘要翻译： 本发明涉及烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善学习和/或记忆的药物的用途。 烷基取代的吡唑并嘧啶具有式（I）：具有如权利要求中所定义的变量。
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公开(公告)号：US08158633B2
公开(公告)日：2012-04-17
申请号：US10525115
申请日：2003-08-12
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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![Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors](/abs-image/US/2011/10/18/US08039477B2/abs.jpg.150x150.jpg)
16.发明授权Substituted pyrazolo[3,4-d]pyrimidin-4-one compounds as phosphodiesterase inhibitors 有权取代的吡唑并[3,4-d]嘧啶-4-酮化合物作为磷酸二酯酶抑制剂公开(公告)号：US08039477B2
公开(公告)日：2011-10-18
申请号：US10524956
申请日：2003-08-13
申请人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Böβ , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory with compounds of formula (I):
摘要翻译： 本发明涉及新的烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善式（I）化合物的感知，浓度，学习和/或记忆的药物：
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公开(公告)号：US20060106035A1
公开(公告)日：2006-05-18
申请号：US10525115
申请日：2003-08-12
申请人： Martin Hendrix , Frank-Gerhard Boss , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Boss , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20120165349A1
公开(公告)日：2012-06-28
申请号：US13410867
申请日：2012-03-02
申请人： Martin HENDRIX , Frank-Gerhard Böß , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin HENDRIX , Frank-Gerhard Böß , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , A61P25/00 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20110294834A1
公开(公告)日：2011-12-01
申请号：US13193931
申请日：2011-07-29
申请人： Martin HENDRIX , Frank-Gerhard Böß , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin HENDRIX , Frank-Gerhard Böß , Nils Burkhardt , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , A61P25/00 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20060111372A1
公开(公告)日：2006-05-25
申请号：US10524956
申请日：2003-08-13
申请人： Martin Hendrix , Frank-Gerhard Boss , Nils Burkhard , Christina Erb , Adrian Tersteegen , Marja Van Kampen
发明人： Martin Hendrix , Frank-Gerhard Boss , Nils Burkhard , Christina Erb , Adrian Tersteegen , Marja Van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention relates to novel alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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