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![6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines](/abs-image/US/2014/08/19/US08809348B2/abs.jpg.150x150.jpg)
公开(公告)号：US08809348B2
公开(公告)日：2014-08-19
申请号：US12580725
申请日：2009-10-16
申请人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , A61P25/18 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20080255118A1
公开(公告)日：2008-10-16
申请号：US10586501
申请日：2004-12-31
IPC分类号： A61K31/5377 , A61K31/513 , C07D401/04 , A61P25/28 , C07D413/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20070161662A1
公开(公告)日：2007-07-12
申请号：US10556437
申请日：2004-04-27
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20070105876A1
公开(公告)日：2007-05-10
申请号：US10556224
申请日：2004-04-28
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20070105881A1
公开(公告)日：2007-05-10
申请号：US10559954
申请日：2004-06-16
申请人： Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/513 , C07D239/14
CPC分类号： C07D239/42 , C07D401/12 , C07D409/12
摘要： The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
摘要翻译： 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。
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公开(公告)号：US20080176898A1
公开(公告)日：2008-07-24
申请号：US11587318
申请日：2005-04-14
申请人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
发明人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
IPC分类号： A61K31/445 , C07D211/06 , A61K31/195 , A61P9/00 , C07C229/06
CPC分类号： C07D211/62 , C07C235/34 , C07C235/36 , C07D205/04 , C07D207/08 , C07D211/60
摘要： The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
摘要翻译： 本发明涉及苯乙酰胺，其制备方法及其用于制备用于治疗和/或预防人和动物尤其是心血管疾病疾病的药物。
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7.发明申请Pyrimidinone derivaties as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权作为急性和慢性炎性，缺血和重塑过程的治疗剂的嘧啶酮衍生物公开(公告)号：US20060160801A1
公开(公告)日：2006-07-20
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allertheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allertheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/513 , C07D413/14 , C07D403/14
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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公开(公告)号：US20100298221A1
公开(公告)日：2010-11-25
申请号：US12440725
申请日：2007-08-30
申请人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
发明人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
IPC分类号： A61K38/16 , C07D213/80 , C07D213/22 , A61K31/444 , A61K31/4412 , A61K31/546 , A61K31/585 , A61K31/55 , A61K31/551 , A61K31/60 , A61K31/4365 , A61K31/519 , A61P3/00 , A61P9/10 , A61P9/00
CPC分类号： C07D213/80
摘要： The present invention relates to novel 2-phenoxy-6-phenyl- and 2-phenoxy-6-pyridylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, especially of dyslipidemias, arteriosclerosis and heart failure.
摘要翻译： 本发明涉及新的2-苯氧基-6-苯基 - 和2-苯氧基-6-吡啶基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。
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公开(公告)号：US20080261990A1
公开(公告)日：2008-10-23
申请号：US11663813
申请日：2005-09-10
申请人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
发明人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
IPC分类号： A61K31/496 , C07D405/12 , A61K31/506 , C07D239/28 , A61K31/505
CPC分类号： C07D239/42 , C07D405/12
摘要： The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防心血管疾病，特别是血脂异常，动脉硬化，冠心病，血栓形成和代谢综合征。
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公开(公告)号：US20080255202A1
公开(公告)日：2008-10-16
申请号：US11547974
申请日：2005-03-26
申请人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
发明人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
IPC分类号： A61K31/4427 , C07D271/06 , A61K31/4245 , C07D261/06 , A61K31/42 , C07D271/10 , C07D231/10 , C07D213/02 , A61P9/00 , A61K31/4155 , C07D277/20 , A61K31/427 , C07D249/08 , A61K31/4196 , C07D233/54
CPC分类号： C07D405/12 , C07D231/12 , C07D249/04 , C07D263/32 , C07D271/06 , C07D277/28 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
摘要翻译： 本申请涉及新的苯硫基乙酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管疾病，特别是血脂异常和动脉硬化。
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